ID A0A091SMH9_NESNO Unreviewed; 1081 AA.
AC A0A091SMH9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Sterol regulatory element-binding protein 2 {ECO:0000256|ARBA:ARBA00039750};
DE AltName: Full=Sterol regulatory element-binding transcription factor 2 {ECO:0000256|ARBA:ARBA00042214};
DE Flags: Fragment;
GN ORFNames=N333_05236 {ECO:0000313|EMBL:KFQ44242.1};
OS Nestor notabilis (Kea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ44242.1, ECO:0000313|Proteomes:UP000053840};
RN [1] {ECO:0000313|EMBL:KFQ44242.1, ECO:0000313|Proteomes:UP000053840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ44242.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SREBP family.
CC {ECO:0000256|ARBA:ARBA00038460}.
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DR EMBL; KK928927; KFQ44242.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091SMH9; -.
DR Proteomes; UP000053840; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18922; bHLHzip_SREBP2; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR46062; STEROL REGULATORY ELEMENT-BINDING PROTEIN; 1.
DR PANTHER; PTHR46062:SF3; STEROL REGULATORY ELEMENT-BINDING PROTEIN 2; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053840};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 270..320
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 27..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..82
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ44242.1"
FT NON_TER 1081
FT /evidence="ECO:0000313|EMBL:KFQ44242.1"
SQ SEQUENCE 1081 AA; 118044 MW; 6D9DC93C174982A9 CRC64;
EMLQFVSNQA GDFPDLFSDH LCGTFQGNSS SSEMQRPYSQ VQLQPFPPPP TSPQLQSLPI
KAAQATPPAP PRSAPLLQPR PPLQPQLQQQ AVMIAPTFSS APQTRIIQQP VIYQNAATSF
QVLQPQVQSL VTSSQVQPVA IQQQVQTVQA QRVLTQAANG TIQTLTPATV QTVAAPQVQQ
VPVLVQPQII KTDSLVLTTL KADGNPVMAA VQNPALTALT APIQTTALQT LVGSNGTILT
TMPVMMGQEK VPIKQVPGGV KQPEPPKEGE RRTTHNIIEK RYRSSINDKI IELKDLVMGT
DAKMHKSGVL RKAIDYIKYL QQANHKLRQE NMVLKLANQK NKLLKGIDLS SLVDNDVDLK
IDDFNQNVLL MSPPASDSGS QAGFSPYSID SEPGSPLLDD AKVKDEPDSP PVALGMVDRS
RILLCALTFL CLSFNPLTSL LDARGTPESD SLVRHGSGRN VLTIESDAGG WFGWMMPTLI
LWLVNGVIVL SVFIKLLVHG EPVTRLHSRS SVTFWRHRKQ ADLDLARGDF AAAASNLQTC
LSVLGRALPA SRLDLACSLS WNVIRYSLQK LALVRWLLKR TSHQWRAREA TAGFEDEAKT
SARDAALAYH KLHQLHITGK LPSSSAYSGL HMALCAVNLA ECAEEKIPPS TMAEIHLTAA
VGLKTRCGGK LGFLASYFLS QAQSLCSSER SAIPDSLRWL CHPLGQKFFV ERSWTVKSAA
KESLYCTQRN PADPIAQVHQ AFCENLLERA VDSLVKPQTR KEIVEQEEEE PCEFSSAMEY
LKLLNSFLDS MGSGAPPFAS NSVLKSALGP DVVCRWWSAA VAMAIAWLRG DDAAVRSHFA
EVERMPKALE MSENALVKAT FYVCKAMQAS LSGKADGQQN SLGHCERASS HLWNSLNMSS
GISSTVLNNM IQLLACDLLL SLRTSLWQKQ ANASQALGET YHASAPELTG FQRDLGSLRK
LAHGFRPAYR KVFLHEATVR LMAGASPTRT HQLLEHSLRR RTPQSSKQGE LDTLPGQRER
ATAILLACRH LPLSFLSSPG QRAVLLAEAA RTLEKVGDKR SCNDCQQMIV KLSGGTAIAA
S
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