ID A0A091SP78_PELCR Unreviewed; 707 AA.
AC A0A091SP78;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=FERM, ARHGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040395};
DE AltName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042170};
DE Flags: Fragment;
GN ORFNames=N334_12844 {ECO:0000313|EMBL:KFQ60404.1};
OS Pelecanus crispus (Dalmatian pelican).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Pelecanidae; Pelecanus.
OX NCBI_TaxID=36300 {ECO:0000313|EMBL:KFQ60404.1, ECO:0000313|Proteomes:UP000054150};
RN [1] {ECO:0000313|EMBL:KFQ60404.1, ECO:0000313|Proteomes:UP000054150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N334 {ECO:0000313|EMBL:KFQ60404.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}.
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DR EMBL; KK480750; KFQ60404.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091SP78; -.
DR Proteomes; UP000054150; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF2; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Reference proteome {ECO:0000313|Proteomes:UP000054150};
KW Synapse {ECO:0000256|ARBA:ARBA00022599};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}.
FT DOMAIN 1..267
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 488..679
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 322..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ60404.1"
FT NON_TER 707
FT /evidence="ECO:0000313|EMBL:KFQ60404.1"
SQ SEQUENCE 707 AA; 81370 MW; D4DED5F1A72EFA45 CRC64;
FFLQQRAPGK VLHDAVCNHL NLVEGDYFGL EFPDHKKMMV WLDLLKPVMK QIRRPKHVVV
KFVVKFFPPD HAQLQEELTR YLFALQVKQD LAQGRLTCND TSTALLISHI VQSEIGDFDE
TIDREHLAKN KYIPQQEALE DKIMEFHRSH MGQTPAESDF QLLEIARRLE MYGIRLHPAK
DREGTKINLA VANTGILVFQ GHTKINAFNW AKVRKLSFKR KRFLIKLRPD VNSSFQDTLE
FLMASRDFCK SFWKICVEHH AFFRLFEEPK PKPKPVLFSR GSSFRFSGRT QKQVLDYVKE
GGHKKVQFER KHSKIHSIRS LTAQPSEQHT EVPKQVSGIS GSFAYGDDND AAAVQSCRQG
KELKASTEDT GQHKSPSLKK SPKEGRKVDG AVVSTVEEEE EAAKDRMQQN RPQSQQPSTG
SLTGSPHLSE LSINSQGGPS VANMSLSPNL SPDAKQSSPL ISPLLNDPTC IRTDDEEEVK
RKRFPTEKAY FIAKEVATTE RTYLKDLEVI TSWFQSAVSK EDCMPETLKN LIFSNFEPLH
KFHTGFLKEI EQRLALWEGR SNAHIKGDYQ RIGDVMLKNI QSMKQLTIHL WKHNEILMEL
ENGIRNSRKL ETFCRDFELQ KVCYLPLNTF LLRPLHRLMH YKQILERLCK HYPPSHTDFR
DSRAALAEIS EMVAQLHGNM IKMENFQKLH ELKKDLIGID NLVIPGR
//
