ID A0A091SY20_PELCR Unreviewed; 2580 AA.
AC A0A091SY20;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Neurofibromin {ECO:0000313|EMBL:KFQ63584.1};
DE Flags: Fragment;
GN ORFNames=N334_01251 {ECO:0000313|EMBL:KFQ63584.1};
OS Pelecanus crispus (Dalmatian pelican).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Pelecanidae; Pelecanus.
OX NCBI_TaxID=36300 {ECO:0000313|EMBL:KFQ63584.1, ECO:0000313|Proteomes:UP000054150};
RN [1] {ECO:0000313|EMBL:KFQ63584.1, ECO:0000313|Proteomes:UP000054150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N334 {ECO:0000313|EMBL:KFQ63584.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK491378; KFQ63584.1; -; Genomic_DNA.
DR Proteomes; UP000054150; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054150}.
FT DOMAIN 1210..1405
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1534..1692
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ63584.1"
FT NON_TER 2580
FT /evidence="ECO:0000313|EMBL:KFQ63584.1"
SQ SEQUENCE 2580 AA; 291288 MW; 1F9FE64E20768B45 CRC64;
LPIKAGQQNT HTKVSTEHNK ECLINISKYK FSLVISGLTN ILKNVNNMRI FGETAEKNLY
LSQLIILDTL EKCLAGQPKD TMRLDETMLV KQLLPEICHF IHTYREGNQH AAELRNSASG
VLFSLSCNNF NAVFSRISTR LQELTVCSED NADVHDIELL QYISVDCSKL KRLLQETVFK
FKALKKVAQL AVINSLEKAF WNWVENYPDE FTKLYQTPQT DMADCAEKLF DLVDGFAEST
KRKAAVWPLQ IILLVLCPEI IQDIAKDVVE ETKMNKKLFL DNLRKALAGH SGSRQLTESA
AIACVKLCKA STYINWEDNS VIFLLVQSMV VDLKNLLFNP SKPFSRGNQN ADVDLMIDCL
VSCFRINPHN NQHFKICLAQ NSPSTFHYVL VNSLHRIITN SALDWWPKID AVYCHSMELR
SMFSETLHKA IQGCGAHPAI RMTPSLTFKE KMTSLKFKEK PTDLETRSYK FLLLSLVKLI
HADPKLLLCN PRKQGPETQG STAELITGLV QLVPQSSMPD IAQEAMEALL VLHQLDSIDL
WNPDAPIETF WEISSQMLFY ICKKLTSHQM LSSTEILKWL REILICRNKF LLKNKQSDRS
SCHFLFLYDV SGGGTSQISL DHEEMIRCAP AATLRKGKGN SSMESTAGCS GTPICRQAQT
KLEVALYMFL WSPDIEAVLV AMSCFRHLCE EADIRCGVDE VSVHNFLPNY NTFMEFASVS
NMMSTGRAAL QKRVMALLRR IEHPTAGNTE AWEDTHAKWE QATKLILNYP KTKMEDGQVT
ESLHKTIVKR RMSHVSGGGS IDLSDTDSLQ EWINMTGFLC ALGGVCLQHR SNAGLATYSP
PMGPVNERKG SMISMVSTEG NAETPVSKFI DRLLTLMVCN HEKVGLQIRS NIKDLVGLEL
SPALYPMLFN KLKNTISKFF DSQGQVLLTE TNTQFVEQTI AIMKNLLDNH TEGSSEHLGQ
ASIETMMLNL VRYVRVLGNL VHAIQIKTKL CQLVEVMMER RDDLSFCQEM KFRNKMVEYL
TDWVMGTSNQ ATDEDVKCLT RDLDQASMEA VVSLLAGLPL QPEEGDGVEL MEAKSQLFLK
YFTLFMNLLN DCSEVEDESA QTGGRKRGMS RRLASLRHCT VLAMSNLLNA NVDSGLMHSI
GLGYHKDLQT RATFMEVLTK ILQQGTEFDT LAETVLADRF ERLVELVTMM GDQGELPIAM
ALANVVPCSQ WDELARVLVT LFDSRHLLYQ LLWNMFSKEV ELADSMQTLF RGNSLASKIM
TFCFKVYGAT YLQKLLEPLL RTVITSSEWQ HVSFEVDPTR LEPTESLEEN QRSLLQMTEK
FFHAIINSSS EFPPQLRSVC HCLYQVVSQR FPQNSIGAVG SAMFLRFINP AIVSPYEAGI
LDKKPPPRIE RGLKLMSKIL QSIANHVLFT KEEHMRPFND FVKSNFDAAR RFFLDIASDC
PASDTVNHSL SFISDGNVLA LHRLLWNNQE KIGQYLSSNR DHKAVGRRPF DKMATLLAYL
GPPEHKPVAD THWSSLNLTS SKFEEFMTRH QVHEKEEFKA LKTLNIFYQA GTSKAGNPVF
YYIARRFKTG QINGDLLIYH VLLTLKPYYA KPYEIVVDLT HAGPSNRFKT DFLSKWFVVF
PGFAYENVSA VFIYNCNSWV REYTKYHERL LTGLKGSKRL IFIDSPGKLA EHIEHDQQKL
PAATLALEED LKVFHNALKL AHKDTKVSIK VGSTAVQVTS AERTRVLGQT VFLNDIYYAS
EIEEICLVDE NQFTLTIANQ GTPLTFMHQE CEAIVRSIIH IRTRWELSQP DSIPQHTKIR
PKDVPGTLLN IALLNLGSSD PSLRSAAYNL LCALTCTFNL KIEGQLLETS GLCIPANNTL
FIVSISKTLA ANEPHLTLEF LEECISGFSK SSIELKHLCL EYMTPWLSNL VRFCKHNDDA
KRQRVTAILD KLITMTINEK QMYPSIQAKI WGSLGQITDL LDVVLDSFIK TSATGGLGSI
KAEVMADTAV ALASGNVKLV SSKVIGRMCK IIDKTCLSPT PTLEQHLMWD DIAILARYML
MLSFNNSLDV AAHLPYLFHV VTLLVATGPL SLRASTHGLV INIIHSLCTC SQLHFSEETK
QVLRLSLTEF SLPKFYLLFG ISKVKSAAVI AFRSSYRDRS FSPGSYERET FALTSLETVT
EALLEIMEAC MRDIPTCKWL DQWTELAQKF AFQYNPSLQP RALVVFGCIS KRVSHGQIKQ
IIRILSKGLE SCLKGPDNYN SQVLIEATVI ALTKLQPLLN KDSPMHKALF WVAMAVLQLD
EVNLYSAGTA LLEQNLHTLD SLRVFNDKSP EEVFMEIRRP LEWHCKQMDH FVGLNFNSNF
NFALVGHLLK GYRHPSPTTV ARTVRILHTL LALVNKHRNC DKFEVNTQSV AYLAALLTVS
EEVRSRCSLK HRKSLLLTDV SMENVPMDTY PIHHSDTSYR TLKENQPWSS PKGSDRHLAA
SYPTVGQISP RTRKSMSLDM GQPSQANTKK LLGTRKSFDH LISDTKAPKR QDMESGITTP
PKMRRVAEND YEMETQRISP QQHPHLRKVS VSESNVLLDE EVLTDPKIQA LLLTVLVSLL
//
