ID A0A091T7N0_NESNO Unreviewed; 1499 AA.
AC A0A091T7N0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Pleckstrin homology domain-containing family H member 2 {ECO:0000313|EMBL:KFQ53897.1};
GN ORFNames=N333_08183 {ECO:0000313|EMBL:KFQ53897.1};
OS Nestor notabilis (Kea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor.
OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ53897.1, ECO:0000313|Proteomes:UP000053840};
RN [1] {ECO:0000313|EMBL:KFQ53897.1, ECO:0000313|Proteomes:UP000053840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ53897.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK945357; KFQ53897.1; -; Genomic_DNA.
DR RefSeq; XP_010017543.1; XM_010019241.1.
DR GeneID; 104409390; -.
DR KEGG; nnt:104409390; -.
DR CTD; 130271; -.
DR OrthoDB; 4538469at2759; -.
DR Proteomes; UP000053840; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13206; FERM_C-lobe_PLEKHH1_PLEKHH2; 1.
DR CDD; cd17179; FERM_F1_PLEKHH2; 1.
DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22903:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 2; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000053840}.
FT DOMAIN 710..804
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 818..926
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 962..1117
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1128..1462
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 196..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1476..1499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 28..172
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 196..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1499 AA; 168642 MW; 4A5D7CE8606D40AB CRC64;
MAELSEPEGT VNWKERCLTL ESQLMKFRLQ ASKIRELLAE KMQQLEKQVI DADRQAERAF
QQVQVMEEKL KAANVQTSES ETRLYKRCQD LEILIQDKND IIQKLEQQLE EQKQIRLQEA
KIIEEKAAKI KEWVTVKLHE LEVENQNLRL INQKQTKEMK TVQSKLQEAT GKKSVTSTQK
PGECQRLSTL TFGCFSNRAR SPQPSSTFEE IIKSSSKESD YTEGKNMLEK DILETTFAGP
AHETNKGQKS LQQSSSGSEQ NKNVRTSCSS KDLDSDMSKN SCTTGSDWSS DEDGGDKGLK
SRCASTLSSH TSEENARYGR VGSEMYLTAS DDSSSLFEEE SFGVQRTQHK KLYSWQQGSQ
RKGQNNPGGK CNSDFTSKKK DQDSSSDELN KKFQSQRLDY SSSSSEANTP SPILTPALTP
KHPILTISAG SQCTTQSDSP SNLPPPKLRT PNVFSINSAL AKKHLSQPQL SSDRMFGRNR
NAISLIRPWR PQETDIDLVD GEDNDILEKM EIGCDEGVFT YDCTEAQNAD TQEPCDMTKK
GAGNKPPTPP LHRFPSWESR IYAVAKSGLR MSEAFTMESL NKSAVSLTSY SVSGLYTSLI
YKNMTTPVYT TLKGKATQIS NSPFIDESSG SEEEDSSRSS SRTSESDSRS RSGPGSPRAM
KRGVSLSSVT SESDYAIPPD AYSVDTDYSE PEQKLPKTSS SSSDSGKNEP LEKSGYLLKM
GGKVKTWKRR WFVLKGGELL YYKSPSDVIR KPQGQIELNA SSQIERGDGK QTIQLTTEKR
TYYLTADSPN ILEEWIKVLQ NVLKIQAASP LFIQPEVKPT MKGLLTKVKH GYSKRVWCTL
VGKILYYFRN QEDKFPLGQI KLFEAKVEEV DRSCDSDEDY EASGRSLLST HYTVVIHPKD
QGPTYLLIGS KHEKDMWLYH LTVAAGSTSV NVGSEFEQLI CKLLNMEGDT TSQVWRHPTL
CHSKEGITSP LTTLPSEALQ TEAIKLFKTC QLFINAAVDA PAIDYHVSLA QSALQICLTH
PELQNEICCQ LIKQTRRRHP QNQAGPIQGL QLLALCIGLF LPQHPFLWLL KLHLKKNADS
RTEFGKYAIY CQRCVERTHQ NGDREARPSR MEILSTLLRN PYYHSLPFSI PVHFMNGIYQ
VVGFDASTTV EEFLNTLNQD TGMRKPAQSG FALFSDDPSG KDIEHCLQGN IKICDIISKW
EQASKEQHPG KCEGTRTVRL TYKNRLYFSV QVHGETEREK LLLVYQTNDQ IVNGLFPVNK
ELAMELTALL AQVEIGDFER PFSTPAGQVT SQSKSNQTLK QVLERFYPKR YRHGCSEEQL
RQLCQRLSTR WMALRGHSAA DCVRIYLTVA RKWSFFGAKL FAARPLATSS VEKSFIWFAI
HEDGISILDY SSMHLTVTYT YKSLMTFGGY QDYFMLVVNN AQAKDKSTEK HLFAMTKPKI
LEITLLIASY INNFHQLKGA AHHLSAPALL TPQSGQKLEE MGSQPLPANN RPTKCPTLL
//
