ID A0A091TCF3_PHALP Unreviewed; 505 AA.
AC A0A091TCF3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Cholesteryl ester transfer protein {ECO:0000256|ARBA:ARBA00022354, ECO:0000256|PIRNR:PIRNR037185};
GN ORFNames=N335_12175 {ECO:0000313|EMBL:KFQ71542.1};
OS Phaethon lepturus (White-tailed tropicbird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Eurypygimorphae; Phaethontiformes;
OC Phaethontidae; Phaethon.
OX NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ71542.1, ECO:0000313|Proteomes:UP000053638};
RN [1] {ECO:0000313|EMBL:KFQ71542.1, ECO:0000313|Proteomes:UP000053638}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ71542.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the transfer of neutral lipids, including
CC cholesteryl ester and triglyceride, among lipoprotein particles. Allows
CC the net movement of cholesteryl ester from high density
CC lipoproteins/HDL to triglyceride-rich very low density
CC lipoproteins/VLDL, and the equimolar transport of triglyceride from
CC VLDL to HDL. {ECO:0000256|PIRNR:PIRNR037185}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z-
CC octadecenoyl)-glycerol(out); Xref=Rhea:RHEA:43352, ChEBI:CHEBI:53753;
CC Evidence={ECO:0000256|ARBA:ARBA00001417};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl
CC (9Z,12Z)-octadecadienoate(out); Xref=Rhea:RHEA:43356,
CC ChEBI:CHEBI:41509; Evidence={ECO:0000256|ARBA:ARBA00001140};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-
CC octadecenoate)(out); Xref=Rhea:RHEA:43348, ChEBI:CHEBI:46898;
CC Evidence={ECO:0000256|ARBA:ARBA00000222};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR037185}.
CC Note=Secreted in plasma. {ECO:0000256|PIRNR:PIRNR037185}.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC {ECO:0000256|PIRNR:PIRNR037185}.
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DR EMBL; KK445605; KFQ71542.1; -; Genomic_DNA.
DR RefSeq; XP_010280945.1; XM_010282643.1.
DR AlphaFoldDB; A0A091TCF3; -.
DR GeneID; 104617357; -.
DR KEGG; plet:104617357; -.
DR CTD; 1071; -.
DR OrthoDB; 5355726at2759; -.
DR PhylomeDB; A0A091TCF3; -.
DR Proteomes; UP000053638; Unassembled WGS sequence.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-UniRule.
DR GO; GO:0120020; F:cholesterol transfer activity; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:UniProtKB-UniRule.
DR GO; GO:0043691; P:reverse cholesterol transport; IEA:InterPro.
DR GO; GO:0034197; P:triglyceride transport; IEA:UniProtKB-UniRule.
DR GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IEA:UniProtKB-UniRule.
DR CDD; cd00025; BPI1; 1.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR017130; Cholesteryl_ester_transfer.
DR InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR47616; CHOLESTERYL ESTER TRANSFER PROTEIN; 1.
DR PANTHER; PTHR47616:SF1; CHOLESTERYL ESTER TRANSFER PROTEIN; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR PIRSF; PIRSF037185; Cholesteryl_ester_transf; 1.
DR SMART; SM00328; BPI1; 1.
DR SMART; SM00329; BPI2; 1.
DR SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 2.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548,
KW ECO:0000256|PIRNR:PIRNR037185};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037185-50};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|PIRNR:PIRNR037185};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|PIRNR:PIRNR037185};
KW Reference proteome {ECO:0000313|Proteomes:UP000053638};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037185};
KW Signal {ECO:0000256|PIRNR:PIRNR037185};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221,
KW ECO:0000256|PIRNR:PIRNR037185};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037185}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|PIRNR:PIRNR037185"
FT CHAIN 25..505
FT /note="Cholesteryl ester transfer protein"
FT /evidence="ECO:0000256|PIRNR:PIRNR037185"
FT /id="PRO_5015219133"
FT DOMAIN 40..267
FT /note="Lipid-binding serum glycoprotein N-terminal"
FT /evidence="ECO:0000259|SMART:SM00328"
FT DOMAIN 281..488
FT /note="Lipid-binding serum glycoprotein C-terminal"
FT /evidence="ECO:0000259|SMART:SM00329"
FT DISULFID 169..210
FT /evidence="ECO:0000256|PIRSR:PIRSR037185-50"
SQ SEQUENCE 505 AA; 56982 MW; 6576D808F6BDAFF8 CRC64;
MLWAGRMRLG TFGILLMLVR ASAACEFGPF PYSVTGIVCR MTKPAALLLN QETAQVIQAA
FRNAKFPNIT GERSMRLLGK VAYGLTNIQV NDLSIEQSEV ELKENDAIHI AIKNVTAFFK
GTLNYGYAGA WFLQLFHSVD FEIESSIDLQ INIKLTCQKD QVAADASDCY LTFHKLTLHL
QGDKEPGWLK QLFTDFISFT LKLVLKREVC NEINFLAQVL ANFVHDLAAN FVRDEDISVD
ISLASAPLIK ANYLESYHKG LIRYKNYSDV FSDSVFSPSL LTESRMLYFW LSEHILNSLA
TAAFLDKRLA LTIRGEKLQA LFEMEDTETQ RKVVQMIFQG TSYNDSVAKV WSLAHPQISL
QPEGTVVKSL VAVEISIFPP GEESLMVLYM EKEITVTIQA AYTEKKLILH PLDSRIEFKV
FKCTADPSGN DPSIRNFLQT MISVVGIPEV ISRIEPALTS LMNSKGLNLF EIRNPEIITR
KGYIIVQLDF SFPNHLLLDF LEKML
//
