ID A0A091TGR1_PHALP Unreviewed; 522 AA.
AC A0A091TGR1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE Flags: Fragment;
GN ORFNames=N335_03919 {ECO:0000313|EMBL:KFQ74344.1};
OS Phaethon lepturus (White-tailed tropicbird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Eurypygimorphae; Phaethontiformes;
OC Phaethontidae; Phaethon.
OX NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ74344.1, ECO:0000313|Proteomes:UP000053638};
RN [1] {ECO:0000313|EMBL:KFQ74344.1, ECO:0000313|Proteomes:UP000053638}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ74344.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK452296; KFQ74344.1; -; Genomic_DNA.
DR RefSeq; XP_010284742.1; XM_010286440.1.
DR AlphaFoldDB; A0A091TGR1; -.
DR GeneID; 104620273; -.
DR KEGG; plet:104620273; -.
DR CTD; 8491; -.
DR OrthoDB; 152877at2759; -.
DR PhylomeDB; A0A091TGR1; -.
DR Proteomes; UP000053638; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008349; F:MAP kinase kinase kinase kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR021160; MAPKKKK.
DR PANTHER; PTHR48012:SF17; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3; 1.
DR PANTHER; PTHR48012; STERILE20-LIKE KINASE, ISOFORM B-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR PIRSF; PIRSF038172; MAPKKKK; 1.
DR SMART; SM00036; CNH; 1.
DR PROSITE; PS50219; CNH; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000313|EMBL:KFQ74344.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053638};
KW Transferase {ECO:0000313|EMBL:KFQ74344.1}.
FT DOMAIN 184..495
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 33..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..71
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..115
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ74344.1"
FT NON_TER 522
FT /evidence="ECO:0000313|EMBL:KFQ74344.1"
SQ SEQUENCE 522 AA; 59021 MW; 3E6EE5407FFD8D81 CRC64;
DLQLEYGHGP QYGYFLGANK SLLKSVEEEL HQRGHVAHLE DDDDDADDDA KHATMKPKVP
PPLPPKPKSI FMPQETHPSE NDNQGTIKRC PMSESPAKSA SHVPPRPPPP RLPPQKSNAL
GNGVISVQLN GEREGSPHQQ NEARESNFSR REKKEILKPI SNGLPPTPKV HMGACFSKVF
NGCPLKIHCA TSWINPDTRD QYLIFGAEEG IYTLNLNELH ETSMEQLFPR RCTWLYVMNN
CLLSVSGKAS QLYSHNLPGL FDYARQMQKL PVAIPAHKLP DRILPRKFAV STKIPDTKWC
QKCCVVRNPY TGHKYLCGAL QSSIVLLEWV EPMQKFMLIK HIDFPVPCPL RLFEMLVVPE
QEFPLVCVGV SRGRDFNQVV KFETVNPNST SSWFTETDTT ETSIVHVTQL ERDTILVCLD
CCIKIVNLQG RLKSSRRLSS ELTFDFQIES IVCLQDSVLA FWKHGMQGRS FRSNEITQEI
SDNTRIFRLL GSDRVVVLES RPTDNPTANS NLYILAGHEN SY
//
