ID   A0A091TI32_PHALP        Unreviewed;       431 AA.
AC   A0A091TI32;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Lipase member H {ECO:0000313|EMBL:KFQ74099.1};
DE   Flags: Fragment;
GN   ORFNames=N335_11417 {ECO:0000313|EMBL:KFQ74099.1};
OS   Phaethon lepturus (White-tailed tropicbird).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Eurypygimorphae; Phaethontiformes;
OC   Phaethontidae; Phaethon.
OX   NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ74099.1, ECO:0000313|Proteomes:UP000053638};
RN   [1] {ECO:0000313|EMBL:KFQ74099.1, ECO:0000313|Proteomes:UP000053638}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ74099.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
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DR   EMBL; KK451973; KFQ74099.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091TI32; -.
DR   PhylomeDB; A0A091TI32; -.
DR   Proteomes; UP000053638; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR   GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; LIPASE; 1.
DR   PANTHER; PTHR11610:SF186; LIPASE H-RELATED; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000865-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053638};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          22..311
FT                   /note="Lipase"
FT                   /evidence="ECO:0000259|Pfam:PF00151"
FT   ACT_SITE        139
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   ACT_SITE        163
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   ACT_SITE        233
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   BINDING         177
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT   BINDING         179
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT   BINDING         182
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ74099.1"
FT   NON_TER         431
FT                   /evidence="ECO:0000313|EMBL:KFQ74099.1"
SQ   SEQUENCE   431 AA;  48524 MW;  7B0BCAC1EC08EC1E CRC64;
     SDPGETCPTF TALSIGNALI GTDLKVKLLL YTRQNQNCAE ELNSTDSKYL DVTKKTTFII
     HGYRLTGSTP LWIHDLVHLL LSVEDMNVIL VDWNRGATTL IYGNASRNCK KVAEILKKLI
     DEMLIDGATL DSLHMIGVSL GAHISGFVGQ MFDGTLGRIT GLDPAGPLYR GKPPSERLDP
     TDAQFVDVIH SDTDGLGYRE ALGHIDFYPN GGTDQPGCPL TIFSGLQYFK CDHQRSVFLF
     LSSLKQSCNI TAYPCDSYRN YRNGKCTSCE TFWPMPCPIL GYYAHRWKSY LTQQSHPVTS
     MFFDTADKDP FCLYHYFVDI ITWNKDTRRG TFSIVLADET GKKAESKINP EAAAFQQYNQ
     ITLLIGFDQD FENVEKVSLT FSTGAVIGPK FKLRILQMRF RSLTNPERPQ LCRYDLVLME
     NTKKTFKPIP C
//