ID A0A091TXR2_PHALP Unreviewed; 1036 AA.
AC A0A091TXR2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
DE Flags: Fragment;
GN ORFNames=N335_05945 {ECO:0000313|EMBL:KFQ83199.1};
OS Phaethon lepturus (White-tailed tropicbird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Eurypygimorphae; Phaethontiformes;
OC Phaethontidae; Phaethon.
OX NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ83199.1, ECO:0000313|Proteomes:UP000053638};
RN [1] {ECO:0000313|EMBL:KFQ83199.1, ECO:0000313|Proteomes:UP000053638}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ83199.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR EMBL; KK468345; KFQ83199.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091TXR2; -.
DR PhylomeDB; A0A091TXR2; -.
DR Proteomes; UP000053638; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd02665; Peptidase_C19I; 1.
DR CDD; cd14355; UBA_UBP28; 1.
DR CDD; cd20487; USP28_C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR044635; UBP14-like.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR43982; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR43982:SF6; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:KFQ83199.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053638}.
FT DOMAIN 146..636
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 95..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 389..416
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 97..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ83199.1"
FT NON_TER 1036
FT /evidence="ECO:0000313|EMBL:KFQ83199.1"
SQ SEQUENCE 1036 AA; 117928 MW; B765A0D302B8A220 CRC64;
DCQMLLNQLK EITGIQDSAF LQAALKAANG DLMEAVTFLT EEHAHEPTQD AAAAEPSAWE
GSAVGKQLPQ NVATALIPNN RDDLPAADAF RPLESPKAQA ADRDAAERPQ DAHSAENKNR
SKRKRCEVWG ENPKQNDWRR VGDWPVGMKN IGNTCWFSAV IQSLFQLPEF RRLVLGYSLP
QNVLESCRSR AGKRNIAFMQ ELQCLFALML GTRRKFVDPS AALELLRDAF RSAEEQQQDV
SEFTHKLLDW LEDAFQLAVN LKSPGDKSEN PMVQLFYGTF LTEGVHEGNT FSKIETFGQY
PLQVNGYRNL NECLEGAMVE GEMDQATASQ SVKYGQERWF TKLPPVLTFE LSRFEFNQSL
GQPEKIHTKL EFPQTIYMDR YLYCSKELIQ MKREEMKRLK EKMVILQQKL ERYMKYGSGP
ARFPLPDMLQ YVLEFIATKP AAVVPSAQGS RTTLLQPQAE PHVLDVLAQP DGVLERKGSR
TEDAAFFLAN PSPQQKSRTP LQPSGSLAEM SECPAPHVVS KEELNLVRTC LQRWRNEIEQ
DMRDLKESIA SINLSIEQMY CDPLLQQVPY RLHAVLVHEG QANAGHYWAY IYDQPRKSWL
KYNDISVTES SWEELERDSF GGLKNASAYC LMYISDKVSR FVADKDDGSE VGQFQKEVEA
LSPELRHYIQ EDNWRLEQEA EEWEEEQSCK IPQMEPSAAS ESQDLSSESG PDQASVCEQS
VRSLSSEHAM IAKEQTAKAI ANTADAYEKN GVEAALCEAF HEEYSRLYLL AKETPTPQND
ARLQHVLVYF LQNNAPQQVV ERTLLEQFAD KNLSYDERSI SIMKVARAKL REIGPDDVDM
EEYKRWHEDY SLFRKVSVYL LTGLELYQNG KYQESLTYLV YAYQSNTKLL MKGTSRGVNE
SLIALYRRKC LLKLNEVAAS LFVSCEEARV AEGISILNEL IIPCMHLMNN FEISKEDLDA
IEVMRNRWCS YLGREDMDAE LQMKLGELLP RLLDCSTEVI VLKEPPKIRP NSPYDLCSRF
AAVMESIHGA STVTVK
//
