ID A0A091UBK3_PHALP Unreviewed; 574 AA.
AC A0A091UBK3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
DE Flags: Fragment;
GN ORFNames=N335_02029 {ECO:0000313|EMBL:KFQ71398.1};
OS Phaethon lepturus (White-tailed tropicbird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Eurypygimorphae; Phaethontiformes;
OC Phaethontidae; Phaethon.
OX NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ71398.1, ECO:0000313|Proteomes:UP000053638};
RN [1] {ECO:0000313|EMBL:KFQ71398.1, ECO:0000313|Proteomes:UP000053638}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ71398.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456215; EC=6.2.1.1;
CC Evidence={ECO:0000256|RuleBase:RU361147};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432, ECO:0000256|RuleBase:RU361147}.
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DR EMBL; KK445040; KFQ71398.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091UBK3; -.
DR PhylomeDB; A0A091UBK3; -.
DR Proteomes; UP000053638; Unassembled WGS sequence.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF110; ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361147};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361147};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU361147};
KW Reference proteome {ECO:0000313|Proteomes:UP000053638}.
FT DOMAIN 6..398
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 454..532
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ71398.1"
FT NON_TER 574
FT /evidence="ECO:0000313|EMBL:KFQ71398.1"
SQ SEQUENCE 574 AA; 63932 MW; 6451169BF9EE6925 CRC64;
TVNCLDQHVE KSPNRVALIW ERDEPGTAVH VTYRELLDLT CRLANTLKKY GIQKGDKVAI
YMSVSPLSVA AMLACARIGA VHTVVFAGFS AESLAGRIMD SGCKAVITYN QGVRGGRIIE
LKMTVDEAVK NCPSIKHVFV AQRTDNKVQM GDRDIPLEEE MAKAASVCTP ESMDSEDMLF
MLYTSGSTGK PKGIVHTQAG YLLYAALTHK YVFDYQQGDV FGCVADIGWI TGHSYVVYGP
LCNGATSVLF ESTPVYPDPG RYWEVVQRLK INQFYGAPTA IRLLLNYGEE WVKKYDRSSL
KTLGSVGEPI NHEAWQWFYH VVGEGRCTLV DTWWQTETGG ICIAPRPSEE KAEIIPAMAM
RPFFGIVPVL MDENGKVIEG NDVSGALCIA QPWPGMARTI YGDHQRFVDA YFKAYPGYYF
TGDGAYRTKK GYYQITGRMD DVINISGHRL GTAEIEDAMA DHPEVPETAV IGYPHKIKGE
GAFAFIVLKE QTTHIDRVKE ELKTIVASKI AKYAVPDHIL VVKRLPKTRS GKIMRRLLRK
VVTEESSNMG DVTTLDDPSV VKEILDAYQK YKEE
//
