ID   A0A091UH25_PHALP        Unreviewed;       880 AA.
AC   A0A091UH25;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=dipeptidyl-peptidase IV {ECO:0000256|ARBA:ARBA00012062};
DE            EC=3.4.14.5 {ECO:0000256|ARBA:ARBA00012062};
DE   Flags: Fragment;
GN   ORFNames=N335_04402 {ECO:0000313|EMBL:KFQ73874.1};
OS   Phaethon lepturus (White-tailed tropicbird).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Eurypygimorphae; Phaethontiformes;
OC   Phaethontidae; Phaethon.
OX   NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ73874.1, ECO:0000313|Proteomes:UP000053638};
RN   [1] {ECO:0000313|EMBL:KFQ73874.1, ECO:0000313|Proteomes:UP000053638}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ73874.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a
CC         polypeptide, preferentially when Yaa is Pro, provided Zaa is neither
CC         Pro nor hydroxyproline.; EC=3.4.14.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001257};
CC   -!- SIMILARITY: Belongs to the peptidase S9B family. DPPIV subfamily.
CC       {ECO:0000256|ARBA:ARBA00010036}.
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DR   EMBL; KK451470; KFQ73874.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091UH25; -.
DR   MEROPS; S09.018; -.
DR   Proteomes; UP000053638; Unassembled WGS sequence.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR045785; Dpp_8/9_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF98; DIPEPTIDYL PEPTIDASE 8; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF19520; Dpp_8_9_N; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053638}.
FT   DOMAIN          1..144
FT                   /note="Dipeptidyl peptidase 8 /9 ,N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19520"
FT   DOMAIN          157..576
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          669..872
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ73874.1"
FT   NON_TER         880
FT                   /evidence="ECO:0000313|EMBL:KFQ73874.1"
SQ   SEQUENCE   880 AA;  100835 MW;  722413F4A105985F CRC64;
     CNMAAAMETE QPSLEIFETA GREEQVQREE QPKLEPLHAG SQLRKLLTDT RKYHGYMMAK
     APHDFTFVKK NDPEGPHSDR IYYLAMSGEN RENTLFYSEI PKTINKAAVL LLSWKPLLDL
     FPAILDYGMY SREEELLRER KRIGTIGIAS YDYHQESGTF LFQAGSGIYH VKDGGPHGFT
     QQPLRPILVE TSCPNIRMDP KLCPADPNWI AFIHSNDIWI SNIETREERR LTFVHNELPN
     VEEDPKSAGV ATFVLQEEFD RYTGYWWSPK AQPTLSGGKV LRILYEENDE SEVEIIHVTS
     PMLETRRTDS FRYPKTGTAN PKVTFKISEV TINAEGRIAD VVDKELVQPF EILFEGVEYI
     ARAGWTPEGK YIWSILLDRS QTRLQIVLIP PALFIPTEDD AMERQKLIDA VPDSVTPFII
     YEETTDIWIN IHDIFYVFPQ SHEDEIEFIF ASECKTGFRH LYKVISVLKE SKYKRSCGGL
     PAPNDFKCPI KEEIAITSGE WEVLGRHGSN IYVDEAKKLV YFQGTKDSPL EHHLYVVNYK
     NPGEVKRLTE RGYSHACCVS QDCDMFISKY SNQKNPHCVS LYRLTGPEDD AAHRTKEIWA
     TILDSAGPLP DYIPPEVFSF ESSTGFTLYG MMYKPHNLQP GKKYPTVLFI YGGPQVQLVN
     NRFKGIKYFR LNTLASLGYV VVVIDNRGSC HRGLKFEGAF KYKMGQIEID DQVEGLQYLA
     SQYDFIDLDR VGIHGWSYGG YLSLMALMQR SDIFRVAIAG APVTLWIFYD TGYTERYMGH
     PDHNEQGYYL GSVAMQADKF PSEPNRLLLL HGFLDENVHF AHTSILLSFL VRAGKPYDLQ
     IYPQERHSIR VPESGEHYEL HLLYYLQENL GSRVAALKAM
//