ID A0A091UIE3_PHORB Unreviewed; 649 AA.
AC A0A091UIE3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=long-chain-fatty-acid--CoA ligase {ECO:0000256|ARBA:ARBA00026121};
DE EC=6.2.1.3 {ECO:0000256|ARBA:ARBA00026121};
DE AltName: Full=Long-chain-fatty-acid--CoA ligase {ECO:0000256|ARBA:ARBA00041297};
GN ORFNames=N337_05101 {ECO:0000313|EMBL:KFQ89465.1};
OS Phoenicopterus ruber ruber.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Phoenicopteriformes; Phoenicopteridae;
OC Phoenicopterus.
OX NCBI_TaxID=9218 {ECO:0000313|EMBL:KFQ89465.1, ECO:0000313|Proteomes:UP000053700};
RN [1] {ECO:0000313|EMBL:KFQ89465.1, ECO:0000313|Proteomes:UP000053700}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N337 {ECO:0000313|EMBL:KFQ89465.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate +
CC tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:65052, ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|ARBA:ARBA00036436};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640;
CC Evidence={ECO:0000256|ARBA:ARBA00036436};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a very long-chain fatty acid + ATP + CoA = a very long-chain
CC fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:54536,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:58950, ChEBI:CHEBI:138261, ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|ARBA:ARBA00036527};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54537;
CC Evidence={ECO:0000256|ARBA:ARBA00036527};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; KK432958; KFQ89465.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091UIE3; -.
DR Proteomes; UP000053700; Unassembled WGS sequence.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43107; LONG-CHAIN FATTY ACID TRANSPORT PROTEIN; 1.
DR PANTHER; PTHR43107:SF11; LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 4; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000053700}.
FT DOMAIN 91..454
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 649 AA; 73242 MW; 808BFBF097813EF5 CRC64;
MAVVSLSPQA TMLRLAAFAA LLLFFRVSLE LSWAQAIPAL FIFYLGSGGW DFFLIFIKTI
RRDVTTGLVL LRVKWQVWRH VREKNTIAKI FQKTASKYPE KTALIFQGTG ESWTFRQLDE
YSNRVANFFH GQGFRSGDVV ALFMESRNQY VGLWLGLAKI GVETALVNSH LRMEALLHCI
TISNSKAVVF GVEMMEAMQE VQPSLEKSIH LFWSGEGSPE SVLPGAQHLD PLLQMAPRHR
PTPPDKGFLD KLFYIYTSGT TGLPKAAIVV NCRYFRMSSL VFYGFRMRPD DVMYDCLPLY
HAAGNIVGVG QCLLQGMTIV IRKKFSASHF WEDCVKYNCT IVQYIGEICR YLLKQPQQHR
VRMALGNGLR ASIWREFMAR FNIAQVAEFY GATECNCSLG NFDNNVGSCG FNSRILPGVY
PIGLVKVDED TMELIRGPDG VCIRCKPGEP GQLVGRIVKS NPLQHFDGYL NQSATNKKIA
RDVFTKGDAA YLTGDVLVMD KYGYMYFRDR TGDTFRWKGE NVSTTEVEGT LSRILNLTDV
VVYGVEIPGI EGKAGMAAIA DPENSCDLEG FASELKKALP LYARPVFLRF LHEVSKTSTY
KFQKMELRKQ GFDPALVKDR LYFLDSRQGR YLPLDQAAFD RIQSGQQKL
//
