ID A0A091UPJ2_NIPNI Unreviewed; 3069 AA.
AC A0A091UPJ2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513, ECO:0000256|RuleBase:RU365027};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513, ECO:0000256|RuleBase:RU365027};
GN ORFNames=Y956_13538 {ECO:0000313|EMBL:KFQ92874.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ92874.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFQ92874.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ92874.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775,
CC ECO:0000256|RuleBase:RU365027};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365027}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769, ECO:0000256|RuleBase:RU365027}.
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DR EMBL; KL409971; KFQ92874.1; -; Genomic_DNA.
DR STRING; 128390.A0A091UPJ2; -.
DR eggNOG; KOG0892; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR InterPro; IPR021668; TAN.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF11640; TAN; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01342; TAN; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU365027};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU365027};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU365027};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365027};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365027};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU365027};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365027}.
FT DOMAIN 1944..2579
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2699..3012
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3037..3069
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1883..1902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1883..1898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3069 AA; 350081 MW; E10D5F5753A4E703 CRC64;
MSLVLHDLLI CCRRLENEKA VERRKEIENF KRLLRDSETV LQLDRNSDSK QAKQLNWDAL
FSVLQKSFQK EMKTLQLTKP NASASTQTTR QKKMQEIGSL VKYFIRCANK RGPRLKCQEL
LIYVMEIIRD PTSCAAYGSD CSGILLKDIL SVRKYWCEIS QQQWSELLIL YGQLYLKPSG
KINRVLVARI IHTLTRGYCF QTDGLSSDML IFFSKAMQCA RQERNTAGLD HIVGAINIIC
NKFAVNCRIR ICKVGEEILP TVLYIWTQYR PKDSLKESII ELFRLQVRIH HPKGAKTQGK
GAYDSTKWQS ILHNLYDLLV NEINLISSRG KYSSSSRNIV VKENLIELMA DICHQVFTED
TKVLEIAQPY AISQREPGDG TVPSKRRRIE LGWEVIRDNL QRSQKDFDVI PWLQITAQLI
SKYPMSLPNS ELPPLLNVLH QLLPQQRRGE RTPYVLKCLT EVALCQNQKT DLKSTHKLEL
QRTWAKIWSL TIRSVSFQQI EVESFGLLGA MIQGSLVVTD KELWKIFSGP ACKPSSSAVH
CLSLVMSAYS VPENLDIGME QNNCERNLDS LLKEAIMKWL LSCYLEEEME ECAELPPVLC
SDFPYLTLQK ILVSLTMKNS RAAMIFFRND AKCMQHLQGK EENNFSDVEE LYLQTTFDEM
DIFTDFAVNV AAKNVTGSRL AIDQNLREAL EYCLLSMSEK LLSSYAPKSK VVAAEHLVRC
VSLFVGVLGC YCYTGIFKEE DACKSELFQK AKSLIHYAGE SISQSKNKLN EDAHINSLRT
LIMQCTKCLC NCTKNSANKM LSNIFLHLLT SKFMNDLVDI CKNLMRFTGK PSELGEVDLT
GNDPEESIME VDNQVSDDLF DDHSVTDISD TNEAGETQNV TGALSPLAEE QLTKQDLLLL
EILRFLCICV TTVQIQTVSF QASDIRRNLL MLTDGSDFDS AKPLHLHVYL VLLKELPIEE
HLLPAGDVRK LLRPLLAMCS LYRRDQEVCK VILNNLLPIA VGLAQYNTHA EETGYAQGQF
LTVVGSFWHL AQEGKCTAPV RVALLNCMKA LLEADPHCKW AILNVINKDL PVSDAFPHFL
ADSHHQVRIL AAKLITSLFQ DVKQKDSSGM SKPLSLKLQQ KAFENAYLQV QEGMRNLVRG
DVSPEDLLDK QCNGKAVLLM LITMVLCCSP VCEKQALFAI CQSVKENGLE PHLVKKAILF
HAQVLKKVSD IFGYKSVEDF MTSHLDYLVM EWLKINDSGY SLSAFPYVLL NYTSLEEFYR
SCYKVLVPHL VIRSQFEDVK SLASKIEKDW RQVLADCFPK ILVNILPYFA CQIEQRDTAS
KVYDMLKDEN CLGKQQMDNL SHSNLPEIVV ELLMTLHEPP DTRVEEGAHL SKYIRELDPA
PNPPHFPSYV IKGTLDYISN CHKSKFKSLV ALLSKSPDSF QKILLALCKH ASDTNNVYKK
HRVLIIYHLF VSLLLKEIKD GLGGAWAFVL RDVIYTLIHH INSRPVIIRE ISMRSFSLCC
DLLHHVCHTA VTCCKDALES HLHVIVGTLI PLAVDQPEIQ EQVLGLLKYL VIDNKDNENL
YQAIKCLDPF PEYPAFKDLR ATQQEIKYSK GPYSLLEEIN HFLSVGVCDS LPLTRLEGLY
DLRKQLEQYK DQMKDLLKNF QEKPEDSVVV KLVVSLLQLC KMAVNHTGEK AVLEAVGSCL
GEIGPVDFST IALQRAENAL DSKAMDILED RKLQWVFIML TQINIALTDN CIDVRAAAVS
CLKNILATKS GSEFWEVYKN KADPMLIYLQ PFRMSRKKFF VVPANDTEAS LETLDDTNLW
IPLGESHETW IKRLTSSILD SGGVQNDILQ LMKPLCEVKT DLCQTLLPYL IHDILLHDSD
ESWRNLLSVH IQKFFTACCK FASSSRSTTP PNSDSEQETH NLRSLDKVPR RAMLAVVDYL
RRQKRSVSGT VFDDSFWLDL NYLEVAIAAQ SCAAHFTALL YAEIYADKIN IDKQQERSSF
KAAKSLTFEE ESQRTAITIL NEKSKEETGI SLQDLLMDIY RSIGEPDSLY GCGGGRMLQP
LARIRTYEHE AVWEKALVTY DLEASLSPST RQAGIIEALQ NFGLCHTLST YLKGLEHENT
EWCAELQEIR YQAAWRNMQW GHISSVKNET GRPGYHESLY DALQSLRDKE FSAFYDSLKD
ARVNEVEELC KGSLESVYSL YPTLCRLQLI GELENIGLLF SRSVTTQQLN DVYLKWQKQS
ELLKDSDFRF QEPIMSLRTV ILEILLEKEG ENTKRECIKD ILTKHLVELS RLARTAKNTQ
LPERAMFQIK QYNPTGYGVS EWQLEEAQVF WAKKEESLAL NILKRMIKKL DADWFQVEND
PHLKLMYTEC LRLCGTWLAE TCLENPTVIM QKYLEKAVEI AASHSGDSSD ELKKGKMKAF
LSLARFSDNQ YQRIENYMKS SEFENKQALL KKAKEEVGLL RERRVQTNRY TVKVQRELEL
DECAIRALTK DCKRFLCKAV ENYISCLLSG EEHDMWIFRL CSLWLENSGV DGVNEMMKKN
AEKIPSYKFL PLMYQLAARM GTKMMGGLGF HEVLNNLMSR ISLDHPHHTL FIILALANAN
KDELLTKPDT IRRNKLIKNA PKEISQLDVD RMEAASNIIN IVRKRRARMV RDVEALCDAY
ITLANVDATP WKSERKGITI PADQPIIKLK NLEDVVVPTM EIKVDPTGQY ENLVTIRSFK
PEFRLAGGVN LPKIIDCVGS DGKERRQLVK GRDDLRQDAV MQQVFQMCNT LLQQNTETRK
RKLTIRRYKV VPLSQRSGVL EWCSGTTPIG EFLVNVEEGA HKRYRPNDYS GYQCQKMMMD
AQRKHSEEKC NIFMEVCENF QPVFRYFCME KFLDPAVWFE KRLAYTRSVA TSSIVGYIVG
LGDRHVQNIL IDEQTAELVH IDLGVAFEQG KILPTPETVP FRLTRDIVDG MGITGVEGVF
RRCCEKTMAV MRNSQEALLT IVEVLLYDPL FDWTMNPLKA LYLQQRPEDE ADMSATLNTD
PQTCKRKASS DDQSFNKVAE RVLMRLQEKL KGVEEGTVLS VGGQVNLLIQ QAMDPKNLSQ
LFPGWKAWV
//
