ID A0A091UT94_NIPNI Unreviewed; 760 AA.
AC A0A091UT94;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
DE Flags: Fragment;
GN ORFNames=Y956_05178 {ECO:0000313|EMBL:KFQ93175.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ93175.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFQ93175.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ93175.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
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DR EMBL; KL410017; KFQ93175.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091UT94; -.
DR STRING; 128390.A0A091UT94; -.
DR eggNOG; KOG0474; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03685; ClC_6_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR002249; Cl_channel-7.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF166; H(+)_CL(-) EXCHANGE TRANSPORTER 7; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01118; CLCHANNEL7.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 81..102
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 130..151
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 181..198
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 242..264
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 276..299
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 331..353
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 442..461
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 467..489
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 501..525
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 531..552
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 696..754
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ93175.1"
FT NON_TER 760
FT /evidence="ECO:0000313|EMBL:KFQ93175.1"
SQ SEQUENCE 760 AA; 84222 MW; AD78CC2C767972DA CRC64;
QLTPSSFLRI GQLSNVDLNE DIRELETELP RQHPNEIPHN EKLLSLKYES LDYDNSENQL
FLEEERRINH AAFRTVEIKR WVICAMIGIL TGLVACFIDI VVENLAGLKY RVVKGNIDKF
TEKGGLSFSL LLWATLNASV VMVGSVIVAF IEPVAAGSGI PQIKCYLNGV KIPHVVRLKT
LVIKVCGVIL SVVGGLAVGK EGPMIHSGAV IAAGISQGRS TSLKRDFKIF EYFRRDTEKR
DFVSAGAAAG VSAAFGAPVG GVLFSLEEGA SFWNQFLTWR IFFASMISTF TLNSVLSVYH
GNAWDLSSPG LINFGRFDNE KMGYTIQEIP IFIFMGVVGG ILGALFNALN YWLTMFRIRY
IHRPCLQVVE AMLVAAVTAT VGFVMIYCSR DCQPIQGSTV AYPLQLFCAD GEYNSMATAF
FNTPEKSVVN LFHDPPGSYN PMTLGMFTLM YFFLACWTYG LTVSAGVFIP SLLIGAAWGR
LFGISLSYLT KGSIWADPGK YALMGAAAQL GGIVRMTLSL TVIMMEATGN VTYGFPIMLV
LMTAKIVGDY FVEGLYDMHI QLQSVPFLHW EAPVTSHSLT AREVMSTPVT CLRRIERVGT
VVDILSDTSS NHNGFPVVES NPDATQVAGL RGLILRSQLI VLLKHKVFVE RANLSLVQRR
LKLKDFRDAY PRFPPIQSIH VSQDERECMI DLSEFMNPSP YTVPQEASLP RVFKLFRALG
LRHLVVVDNR NEVVGMVTRK DLARYRLGKE GLEELSLAQT
//
