ID A0A091UVQ5_NIPNI Unreviewed; 475 AA.
AC A0A091UVQ5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Metalloendopeptidase OMA1, mitochondrial {ECO:0000256|ARBA:ARBA00040360};
DE AltName: Full=Overlapping with the m-AAA protease 1 homolog {ECO:0000256|ARBA:ARBA00042978};
DE Flags: Fragment;
GN ORFNames=Y956_08836 {ECO:0000313|EMBL:KFQ94050.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ94050.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFQ94050.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ94050.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBUNIT: Homooligomer. {ECO:0000256|ARBA:ARBA00011182}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}.
CC -!- SIMILARITY: Belongs to the peptidase M48 family.
CC {ECO:0000256|ARBA:ARBA00038233}.
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DR EMBL; KL410116; KFQ94050.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091UVQ5; -.
DR STRING; 128390.A0A091UVQ5; -.
DR eggNOG; KOG2661; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07331; M48C_Oma1_like; 1.
DR Gene3D; 3.30.2010.10; Metalloproteases ('zincins'), catalytic domain; 1.
DR InterPro; IPR001915; Peptidase_M48.
DR PANTHER; PTHR22726; METALLOENDOPEPTIDASE OMA1; 1.
DR PANTHER; PTHR22726:SF1; METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL; 1.
DR Pfam; PF01435; Peptidase_M48; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 159..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 227..415
FT /note="Peptidase M48"
FT /evidence="ECO:0000259|Pfam:PF01435"
FT REGION 454..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 475
FT /evidence="ECO:0000313|EMBL:KFQ94050.1"
SQ SEQUENCE 475 AA; 54344 MW; F2AA41EEC452E567 CRC64;
MNIICGLKLP GRNCVFFHLA SLTKQEKCNN LYRNFIGKRL MCLLNVPNTE VYKIAHCSSG
RFCFQSSGPL REKITSLQIS SVGQFAHHFS AWNIHIIRSF HTSLSIQAAP VPLFWIIVKP
AQKLFAIVLG RSIRNWWKAL PPNKRELFKE SARKNKWKIL LGVSSLGVLF VVFYFTHLEE
TPITGRARLL VFGKEHFREL SQMEYDMWVE EFKNKMLPET DARYQVVERV VGHLSESNKD
IPQVSALKWV IHVVDEPDVN AFVLPHGQVF VFTGLLNAVS DIHQLSFILG HEIAHAVLEH
AVKKASLVHF LDFLSLIFLA MIWAICPRDS LAVVGQWIQS KLQEFIFDRP YSRTLEAEAD
KVGLQFAAKA CVDVRASTVF WQQMELAETI QGQPKLPEWL STHPSHENRA EHLDRLIPEA
LKIRESCNCP SLSGPDPRLI FKLNMQHLLE LSKGQETLNS TKRDLSQPKL DFPHT
//
