ID   A0A091UZG8_NIPNI        Unreviewed;       662 AA.
AC   A0A091UZG8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Histidine ammonia-lyase {ECO:0000256|ARBA:ARBA00017271, ECO:0000256|RuleBase:RU004479};
DE            EC=4.3.1.3 {ECO:0000256|ARBA:ARBA00012994, ECO:0000256|RuleBase:RU004479};
GN   ORFNames=Y956_04061 {ECO:0000313|EMBL:KFQ96086.1};
OS   Nipponia nippon (Crested ibis) (Ibis nippon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC   Nipponia.
OX   NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ96086.1, ECO:0000313|Proteomes:UP000053283};
RN   [1] {ECO:0000313|EMBL:KFQ96086.1, ECO:0000313|Proteomes:UP000053283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ96086.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-histidine = NH4(+) + trans-urocanate; Xref=Rhea:RHEA:21232,
CC         ChEBI:CHEBI:17771, ChEBI:CHEBI:28938, ChEBI:CHEBI:57595; EC=4.3.1.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00000171,
CC         ECO:0000256|RuleBase:RU004479};
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
CC       {ECO:0000256|ARBA:ARBA00005113, ECO:0000256|RuleBase:RU004479}.
CC   -!- SIMILARITY: Belongs to the PAL/histidase family.
CC       {ECO:0000256|ARBA:ARBA00007238, ECO:0000256|RuleBase:RU003954}.
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DR   EMBL; KL410330; KFQ96086.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091UZG8; -.
DR   STRING; 128390.A0A091UZG8; -.
DR   eggNOG; KOG0222; Eukaryota.
DR   UniPathway; UPA00379; UER00549.
DR   Proteomes; UP000053283; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR   CDD; cd00332; PAL-HAL; 1.
DR   Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR   Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR   InterPro; IPR001106; Aromatic_Lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR005921; HutH.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   InterPro; IPR022313; Phe/His_NH3-lyase_AS.
DR   NCBIfam; TIGR01225; hutH; 1.
DR   PANTHER; PTHR10362; HISTIDINE AMMONIA-LYASE; 1.
DR   PANTHER; PTHR10362:SF7; HISTIDINE AMMONIA-LYASE; 1.
DR   Pfam; PF00221; Lyase_aromatic; 1.
DR   SUPFAM; SSF48557; L-aspartase-like; 1.
DR   PROSITE; PS00488; PAL_HISTIDASE; 1.
PE   3: Inferred from homology;
KW   Histidine metabolism {ECO:0000256|ARBA:ARBA00022808,
KW   ECO:0000256|RuleBase:RU004479};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU003954};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053283}.
SQ   SEQUENCE   662 AA;  73016 MW;  21BDA330665DB675 CRC64;
     MPRYTVHVRG EWLAVPCLNC TNTVGWLGKE AVRRYMKNKP DNGGFASVEE VKFYIRRCKG
     LGLLDLEDTV EDALEDNEFV EVVIEGDIMS PDFIPSQPEG VHLYSKYREP EQYISLDGNS
     LTTEDLVNLG KGLYKRKLTP KAEAKVKQSR EVIERIVKEQ TVVYGITTGF GKFARTVIPN
     SKLRELQVNL VRSHSAGVGK PLTPERSRML LALRINVLAK GYSGISLETL QQVIEAFNAS
     CLPYIPEKGT VGASGDLAPL SHLALGLTGE GKMWSPKSGW ADAKYVLEAH GLRPITLKPK
     EGLALINGTQ MITSLGCEAV ERASAIARQA DIIAALTLEV LKGTTRAFDT DIHAVRPHRG
     QAEVAFRFRS LLDSDHHPSE IAESHRFCDR VQDAYTMRCC PQVHGVVNDT IAFVKDIMTT
     EINSATDNPM VFAERAETIS GGNFHGEYPA KALDYLAIGV HELAAISERR IERLCNPSLS
     ELPAFLVTEG GLNSGFMIAH CTAAALVSEN KALCHPSSVD SLSTSAATED HVSMGGWAAR
     KALRVIEHVE QVLAIELLAA CQGIEFLRPL KTTTPLEKVY DLVRSVVRPW MKDRFMAPDI
     EAAHRLLVEQ KASVWEVAKP YIEKYRREHI PESRPISPTA FSLGSLEMNT GVGHDCGHQD
     EL
//