ID   A0A091V0Y5_NIPNI        Unreviewed;       624 AA.
AC   A0A091V0Y5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=PH and SEC7 domain-containing protein 3 {ECO:0000313|EMBL:KFQ96332.1};
DE   Flags: Fragment;
GN   ORFNames=Y956_04610 {ECO:0000313|EMBL:KFQ96332.1};
OS   Nipponia nippon (Crested ibis) (Ibis nippon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC   Nipponia.
OX   NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ96332.1, ECO:0000313|Proteomes:UP000053283};
RN   [1] {ECO:0000313|EMBL:KFQ96332.1, ECO:0000313|Proteomes:UP000053283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ96332.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC       {ECO:0000256|ARBA:ARBA00004632}.
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DR   EMBL; KL410371; KFQ96332.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091V0Y5; -.
DR   eggNOG; KOG0932; Eukaryota.
DR   Proteomes; UP000053283; Unassembled WGS sequence.
DR   GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd13295; PH_EFA6; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041681; PH_9.
DR   InterPro; IPR001605; PH_dom-spectrin-type.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR10663:SF337; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF15410; PH_9; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   PRINTS; PR00683; SPECTRINPH.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053283}.
FT   DOMAIN          135..311
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   DOMAIN          362..475
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          318..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          573..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        318..338
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        584..601
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        602..617
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ96332.1"
FT   NON_TER         624
FT                   /evidence="ECO:0000313|EMBL:KFQ96332.1"
SQ   SEQUENCE   624 AA;  70213 MW;  3171730DF4E6273F CRC64;
     EDVLGQRHSD VSTDLYSSQF ENILDNASLY YSAESLETLY SEPDSYFSFE MPLTPMIQQR
     MKEGGQFLDR TSASGQPDVL QLPPDGEVKG CGEGITNGLR DVSETLFRGD VTEVPRLESN
     AELQNMVLDS SAAMGSNELQ EKEATGALGH DLSNGSSSNL EAARRLAKRL YHLDRFKRSD
     VAKHLGKNNE FSRLVAEEYL KFFDFTGMTL DYSLRSFFKA FSLIGETQER ERVLIHFSSR
     YYQCNPNTIS SQDGVHCLTC AMMLLNTDLH GHNIGKKMTC QEFIANLQGM NDGKDFPKGL
     LKALYNSIKN EKLEWAVDEE EKKKSHSDGT DEKDNGSQTK AVSRIGNSNN PFLDIPHDPN
     AAVYKTGFLA RKSHADMDGK KTPRGKRGWK TFYAVLKGTV LYLQKDEYKP EKALSEEDLK
     NAVSVHHALA SKATDYEKKP NVLKLKTADW RVLLFQAQSQ EEMQTWINKI NCVAAVFSAP
     PFPAAIGSQK KFSRPLLPAT TTKLSQDEQL KSHEAKLKQI STELAEHRSY PPDKKLKGKE
     VDDYKLKDHY LEFEKNRYEI YVGLLKEGVK ELLSGGENDA PGLKKSHSSP SLNQESPVSA
     KVKRNVSERK DYRPETPSIK QKVT
//