ID A0A091V1C2_NIPNI Unreviewed; 904 AA.
AC A0A091V1C2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030520};
GN ORFNames=Y956_11396 {ECO:0000313|EMBL:KFQ96502.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ96502.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFQ96502.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ96502.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-
CC tRNA(Leu); Xref=Rhea:RHEA:11688, Rhea:RHEA-COMP:9613, Rhea:RHEA-
CC COMP:9622, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57427,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:456215; EC=6.1.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001372};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR EMBL; KL410402; KFQ96502.1; -; Genomic_DNA.
DR RefSeq; XP_009462741.1; XM_009464466.1.
DR AlphaFoldDB; A0A091V1C2; -.
DR STRING; 128390.A0A091V1C2; -.
DR GeneID; 104012115; -.
DR KEGG; nni:104012115; -.
DR CTD; 23395; -.
DR eggNOG; KOG0435; Eukaryota.
DR OrthoDB; 2876972at2759; -.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07958; Anticodon_Ia_Leu_BEm; 1.
DR CDD; cd00812; LeuRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR002302; Leu-tRNA-ligase.
DR InterPro; IPR025709; Leu_tRNA-synth_edit.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00396; leuS_bact; 1.
DR PANTHER; PTHR43740:SF3; LEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43740; LEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 3.
DR Pfam; PF13603; tRNA-synt_1_2; 1.
DR PRINTS; PR00985; TRNASYNTHLEU.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283}.
FT DOMAIN 68..259
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 271..429
FT /note="Leucyl-tRNA synthetase editing"
FT /evidence="ECO:0000259|Pfam:PF13603"
FT DOMAIN 444..601
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 639..679
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 727..842
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
SQ SEQUENCE 904 AA; 103211 MW; A97F3D997C677F1D CRC64;
MELVCQRVGT CSSCLKRQLN GFLGSIKWQR RLVPACVRTI YSETGKWEKS YGLETRKRVE
NWWLPRIKDQ FCKISETDKS RPKFYVLSMF PYPSGKLHMG HVRVYTISDA VARFQKMRGM
QVINPMGWDA FGLPAENAAV EHGLHPASWT QSNIQHMREQ FDALGLSFTW EREVTTCLPE
YYKWTQYLFL KLFEAGIVYQ KEALVNWDPV DQTVLANEQV DDNGCSWRSG AKVEQKYLKQ
WFIKTTAYAK AMFDALSDLP EWYGIKEMQA NWIGDCVGCS LDFLLKVNGK VTEEKLAAYT
YTPEAIYGAS HLYILPTHRL LHGNSSLKEV FQREFIPGKD TLTSVTAVNL LTNQEIPVVI
SAKNNFENFL DTKIGIPSTS AEDAAVAKSL GISFTEVTET LPNGLEKVIN SGEITGMTRQ
EALKTITQQA KNKGIGGDLT SDKLRDWLIS RQRYWGTPIP VIHCQTCGTV PVPYEDLPVV
LPSVTTFTGK GASPLETASE WVNCSCPRCK AAARREVDTM DTFVDSAWYY LRYTDPHNAD
RPFNNDLADY WMPVDLYIGG KEHAVMHLFY ARFFSHFCHD LKMTKHREPF HKLLVQGLIK
NRTFRLATTG QCLKREEVDL TGTEPVYVKT GEKLQVAWEK MSKSKHNGID PEELVKEYGI
DTLRLYILFA APPEQDILWD TKTDAMPGVQ RWQTRLWTLV TKLIEARTSG TMPNPELLNK
KEKAEARKIW EQKNLVISEV TEYFTKDHLF NAAISRLMSL TNVLHQASRP LILHSTEFED
ALATLCIMVA PMAPHIASEM WKGLAHMQNK LCTHHHWDVD VLHQSWPKVD PEYLQPSDVV
EMSVLINNKA CGKVFVPQQA SRNFEEVHEL VLQSELGVKH LQGRTIKKAF LSPRTALINF
LVQE
//
