UniProt: A0A091V4M6

Database: UniProt
Entry: A0A091V4M6_OPIHO

LinkDB:  A0A091V4M6_OPIHO 
Original site:  A0A091V4M6_OPIHO

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Ontology (2)   
   GO (2)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (33)   
   InterPro (17)   
   Pfam (9)   
   PROSITE (2)   
   SMART (5)   
All databases (36)   

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ID   A0A091V4M6_OPIHO        Unreviewed;      1752 AA.
AC   A0A091V4M6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 {ECO:0000313|EMBL:KFQ97943.1};
DE   Flags: Fragment;
GN   ORFNames=N306_00583 {ECO:0000313|EMBL:KFQ97943.1};
OS   Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC   Opisthocomus.
OX   NCBI_TaxID=30419 {ECO:0000313|EMBL:KFQ97943.1, ECO:0000313|Proteomes:UP000053605};
RN   [1] {ECO:0000313|EMBL:KFQ97943.1, ECO:0000313|Proteomes:UP000053605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N306 {ECO:0000313|EMBL:KFQ97943.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR   EMBL; KK733650; KFQ97943.1; -; Genomic_DNA.
DR   STRING; 30419.A0A091V4M6; -.
DR   PhylomeDB; A0A091V4M6; -.
DR   Proteomes; UP000053605; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd02897; A2M_2; 1.
DR   CDD; cd00104; KAZAL_FS; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.120.1540; -; 1.
DR   Gene3D; 2.60.40.1930; -; 4.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 3.30.60.30; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR041813; A2M_TED.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR022041; Methyltransf_FA.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR041555; MG3.
DR   InterPro; IPR040839; MG4.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412:SF139; C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 8; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF07648; Kazal_2; 1.
DR   Pfam; PF12248; Methyltransf_FA; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF17791; MG3; 1.
DR   Pfam; PF17789; MG4; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          1706..1752
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
FT   REGION          1497..1529
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1508..1529
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFQ97943.1"
FT   NON_TER         1752
FT                   /evidence="ECO:0000313|EMBL:KFQ97943.1"
SQ   SEQUENCE   1752 AA;  195558 MW;  0BD9A05CB4AC11B1 CRC64;
     GYLIAAPSVF RSGVEEAISV TIFNSVKDTT VQVQLVVKGE TVSRGHGTVL DKGTIKLKVP
     SGLRGQAHLK VWGNRHLAEE GYIFHNYTTV TIDSKGSSVF IQTDKPVYKP KQKVLINLFM
     VTSDLRPVND RIEAYVVDPR GSRMIEWSNL KPFCCGIVNM TFPLSDQPVF GEWLIFAEMQ
     GHTYNKSFEV QKYVLPKFEL LIDPPRYIRD LSLCEKGTVH ARYTFGKPVT GKLIVNMTIN
     GVGYYRHEVG HPVLKTTQID GSAVFDVCVK DMMPADVPEH FRGTVNIWAT VISSDGSKQV
     TFDDSTPVQK QLIDIKYSKD TRKQFKPGLP YKGKVEVTYP DGSPADRVTV RIKAELTPKD
     NVYTSELVSR NGLVEFEIPS IPTAAQYVWL ETKVTAIDGK PSGDQYLPNY LSISSWYSPS
     KCHIQLQAPD KPFQVGEEAW IAVKSTCPCN FSLHYEVASR GNIVLSGLQP SNITQQRSKR
     ATLPFEKNTD ITHLPGTAPT DMPAAEVEVC MTFLRFSVVH NMAPLGRLLV YYVRENGEGV
     TDSLQFTVKS SFENQVAVAL SANETRPGDV VNIKVKAAKS SCVCIATVDK SVYLLKTGFQ
     LTASQVFQEL AEYDVSDAFG ALKEEGHFWW PGMSSRRRRR SSVFPWHWDI TKDARFAFTE
     TGLVVMTDIV SLNHRQNGGM YTDEAVPAFQ PHTGTLVATM HSKIAPSRAE KRKRTFFPET
     WIWHCLNVSN VSGEAQLHVE VPDSITTWIT EAVGLSEEKG LGIASQSELK TFKPFFIDFT
     LPYHVIRGEQ TKIPLTVYNY LTVCVEVHVK ISVPKGIKFV GHPGKHHLTR KKCVAPGEAK
     PTSIVLSFSE LGLSNITAKA FAYGGTNCCQ DGMQTLKNGR HSEDNYMDKR TPVGVDYVRS
     TVIIEPEGLS REYTYSVFFC PNEKIHISTP NKYEYQYMQK PAQMTHFDIA VKAHNDAHLA
     LSSGPHDMAE MTEIVIGGHQ NTKTWISISK MGEPVVSRDT AGILSWDEFR SFWISWKNGI
     IQVGHGTRVL NESIIVEWTV PRQLEVKYIG FSTGWGSMGE FKIWRKEETD ENHNEAFTLG
     VPHNIIPGSE RATASIIGDV MGPTLNNLDN LLRLPFGCGE QNMIHFAPNV FVLKYLQKTK
     QLSHEVESEA TDYLVQGYQR QLTYKRQDGS YSAFGERDSS GSMWLTAFVL KSFAQSRGFI
     FIDPKELTAA KDWIIQHQKE DGSFPAMGRI LNKDIQGGIH GKISLTAYVV ASLLETGVTS
     EEESTAVDKA KHFLESNLYS AEDPYTTALV AYALTLLHSP SAAVTLRKMN SMAITQDGFT
     HWSLTGTLAT DEDTFMGFND GLSQSVVSAE VEMTSYALLT YTLLGDVASA LPVVKWLSQQ
     RNALGGFSST QDTCVALQAL AEYAILSYVG GVNLTISLAS TNLDYQETFE LNKMNKKVLQ
     TAVIPSIPTG LFVSAKGEGC CLMQIDVTYN VPDPIAKPAF QLLVNLKEPK SEQDLQAPNL
     LRSVSPDENR SEALHRERAL VDDDDPASDQ DHREYKVILE TCTRLFSFFL FVLMGRWLHS
     GSSNMAVLEV PLFSGFRADI ESLEQLLVNK QIGLKRYEVD GRKVLFYFDE IPSQCMTCVK
     FQAYREHIVG KTAPVPIKVY DYYEPAFEAT RFYNVSENSP LARELCDGPT CNEVESSASQ
     WVGFVHSGPC NNIFGCLEDE YFEQCMCSRD CGYDGEPVCG SDGQIYPNHC QMEVASCRNN
     TRIEQMPMSQ CS
//

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