ID A0A091V5Z9_NIPNI Unreviewed; 331 AA.
AC A0A091V5Z9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=tRNA methyltransferase 10 homolog C {ECO:0000256|ARBA:ARBA00014681};
DE EC=2.1.1.218 {ECO:0000256|ARBA:ARBA00012794};
DE EC=2.1.1.221 {ECO:0000256|ARBA:ARBA00012797};
DE AltName: Full=Mitochondrial ribonuclease P protein 1 {ECO:0000256|ARBA:ARBA00030623};
DE AltName: Full=RNA (guanine-9-)-methyltransferase domain-containing protein 1 {ECO:0000256|ARBA:ARBA00029803};
DE AltName: Full=mRNA methyladenosine-N(1)-methyltransferase {ECO:0000256|ARBA:ARBA00031759};
DE AltName: Full=tRNA (adenine(9)-N(1))-methyltransferase {ECO:0000256|ARBA:ARBA00033019};
DE AltName: Full=tRNA (guanine(9)-N(1))-methyltransferase {ECO:0000256|ARBA:ARBA00029727};
DE Flags: Fragment;
GN ORFNames=Y956_09457 {ECO:0000313|EMBL:KFQ98458.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ98458.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFQ98458.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ98458.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-
CC methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:43148, Rhea:RHEA-COMP:10363, Rhea:RHEA-COMP:10364,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; EC=2.1.1.218;
CC Evidence={ECO:0000256|ARBA:ARBA00001023};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-
CC methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:55392, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12415,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:74491;
CC Evidence={ECO:0000256|ARBA:ARBA00033688};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-
CC methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:43156, Rhea:RHEA-COMP:10367, Rhea:RHEA-COMP:10368,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.221;
CC Evidence={ECO:0000256|ARBA:ARBA00000855};
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DR EMBL; KL410714; KFQ98458.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091V5Z9; -.
DR STRING; 128390.A0A091V5Z9; -.
DR eggNOG; KOG2967; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0160106; F:tRNA (adenine(9)-N1)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0052905; F:tRNA (guanosine(9)-N1)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0008033; P:tRNA processing; IEA:InterPro.
DR CDD; cd18102; Trm10_MRRP1; 1.
DR Gene3D; 3.40.1280.30; -; 1.
DR InterPro; IPR028564; MT_TRM10-typ.
DR InterPro; IPR038459; MT_TRM10-typ_sf.
DR InterPro; IPR025812; Trm10_C_MTase_dom.
DR InterPro; IPR007356; tRNA_m1G_MeTrfase_euk.
DR InterPro; IPR016009; tRNA_MeTrfase_TRMD/TRM10.
DR PANTHER; PTHR13563; TRNA (GUANINE-9-) METHYLTRANSFERASE; 1.
DR PANTHER; PTHR13563:SF5; TRNA METHYLTRANSFERASE 10 HOMOLOG C; 1.
DR Pfam; PF01746; tRNA_m1G_MT; 1.
DR PROSITE; PS51675; SAM_MT_TRM10; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 134..326
FT /note="SAM-dependent MTase TRM10-type"
FT /evidence="ECO:0000259|PROSITE:PS51675"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ98458.1"
FT NON_TER 331
FT /evidence="ECO:0000313|EMBL:KFQ98458.1"
SQ SEQUENCE 331 AA; 38636 MW; F83278324077A354 CRC64;
SCSPSEKLDL DAWKKVMKSG VQEEVSETVS EHKELSSLAA AREILEMWRL AGRSVPENIS
EEQLKTFMEC PSKSAKKKYL KYLHLKELYK RNDKRKMDEK RERRLETQEQ ASKTDETRRN
SFVCLWANCM DRAYSWRVAQ SMIFGQPLVF DMSYEKDMSA REVANTVRQL VLSEGCNRRS
VDPFHIHFCN LKDDSLYHKE FIKHYREAWG KLLITVTDQC YTDVFPKDKL IYLTADSPKV
MKTFDHNKIY IVGSMVDRSI KTGVSLARAK RLGLETAALP LEKYLLWNTG AKNLTLDQMM
HILLTLKDTG DWKKALEFVP KRKYYGFVTK P
//
