ID A0A091VBA1_PHORB Unreviewed; 924 AA.
AC A0A091VBA1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 2 {ECO:0000313|EMBL:KFQ86963.1};
DE Flags: Fragment;
GN ORFNames=N337_00804 {ECO:0000313|EMBL:KFQ86963.1};
OS Phoenicopterus ruber ruber.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Phoenicopteriformes; Phoenicopteridae;
OC Phoenicopterus.
OX NCBI_TaxID=9218 {ECO:0000313|EMBL:KFQ86963.1, ECO:0000313|Proteomes:UP000053700};
RN [1] {ECO:0000313|EMBL:KFQ86963.1, ECO:0000313|Proteomes:UP000053700}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N337 {ECO:0000313|EMBL:KFQ86963.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK422661; KFQ86963.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091VBA1; -.
DR Proteomes; UP000053700; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000053700}.
FT DOMAIN 1..213
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 421..612
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 641..738
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 815..912
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 321..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 523..553
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 321..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ86963.1"
FT NON_TER 924
FT /evidence="ECO:0000313|EMBL:KFQ86963.1"
SQ SEQUENCE 924 AA; 106447 MW; 3C388CA39913CD81 CRC64;
PKTTMLRLAV KFFPPDPGQL QEEYTRYLFA LQIKRDLAEE RLTCSDNTAA LLVSHLLQSE
IGDFDESEDR EHLKTNQYLP NQERIEGKIL EFHRKHVGQT PAGSYFQVLE IARKLEMYGI
RFHLASDREG TKINLAVSHM GVLVFQGNTK INTFNWSKVR KLSFKRKRFL IKLHPEVCGP
YQDTLEFLLG SRDECKNFWK ICVEYHTFFR LFDQPKPKAK AVFFTRGSSF RYSGRTQKQL
VDYIKDSGMK KTPYESQGAP LFTLTNSQLQ VSEEFIDDDP AEISFFAGGS EAFSYMYSGL
ELKGSDFSKC VSESPGLTTD ALQQNTVSSQ SSPDRRKPSL VQASEWSSSP PPDTVPSAVD
HPQLSSLVLK SPLGLNPAFQ VNLNAASQGS SPLLSPVLSD ADGARIEEDD EMKRKRYPTD
KAYFIAKEIL ATERTYLKDL EVITVWFRSA VIKENAMPEG LMTLLFSNID PIYEFHRGFL
KEIEQRLSLW EGRTNAHMKG DYQRIGDVML RNMRTLKEFT SYLQKHDEVL TELEKATKRL
KKLEMVYKEF ELQKVCYLPL NTFLLKPIQR LMHYKLILGR LCKHYTAEHR DFADCRSALK
EVTEMTSQLQ HSLIRLENFQ KLTELQHDLI GIDNLTAPGR EFIREGCLYK LTKKGLQQRM
FFLFSDMLLY TSKGVTGTNQ FKIHGHLPLH GMLVEESENE WAVPHCFTIY SAQKTIVVAA
STRLEMGKWM EDLNTAIEMA KKSTEKSDVL LENSVCNRSN RSSDEVSLEQ ESEDDIHSSR
SSLDRQSHHR ANTTMHVCWY RNTSVSMTDH SVAVENQLSG YLLRKFKNSN GWQKLWVVFT
NFCLFFYKTH QDDYPLASLP LLGYAVSSPV EADGIQKDYV FKLQFKSHVY FFRAESKYTF
ERWMEVIKRA TSSPARSSLL LPKD
//
