ID A0A091VBH7_NIPNI Unreviewed; 543 AA.
AC A0A091VBH7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=medium-chain acyl-CoA ligase {ECO:0000256|ARBA:ARBA00039009};
DE EC=6.2.1.2 {ECO:0000256|ARBA:ARBA00039009};
DE Flags: Fragment;
GN ORFNames=Y956_00499 {ECO:0000313|EMBL:KFQ99777.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ99777.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFQ99777.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ99777.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a medium chain fatty acid + ATP + CoA = a medium-chain fatty
CC acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:48340,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:59558, ChEBI:CHEBI:90546, ChEBI:CHEBI:456215; EC=6.2.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00036212};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48341;
CC Evidence={ECO:0000256|ARBA:ARBA00036212};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; KL410807; KFQ99777.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091VBH7; -.
DR STRING; 128390.A0A091VBH7; -.
DR eggNOG; KOG1175; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05928; MACS_euk; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR43605:SF3; ACYL-COENZYME A SYNTHETASE ACSM2B, MITOCHONDRIAL; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283}.
FT DOMAIN 36..386
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 450..530
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ99777.1"
FT NON_TER 543
FT /evidence="ECO:0000313|EMBL:KFQ99777.1"
SQ SEQUENCE 543 AA; 61168 MW; D8B32DACF78764EE CRC64;
YEAIKQQYRP EVPEYFNFAR DVLDRWTGVE KEGKKSKNPA LWWVDGAGEE VRWSFEELGV
LSRKVANVLS DACGLQRGDR VILILPRIPE WWLVNVACMR TGTVLIPGTQ QLTAKDILHR
LQKSKAKCII TDDSVAPAVD SVGADCQSLK FKLLVSEGHR EGWLNFKDLL KNASSDHHCV
TTKCQDPMAI YFTSGTTGSP KMAEHSHSSY GIGLTVSGRY WLDLTSSDIF WNTSDTGWAK
SAWSSIFSPW IQGACVFVHK MPHFDPRIVF ESLSRFPITV FCSPPTAYRM FVQHKLSGYM
FKSLRHCVSA GEPINPDVME EWKAQTGLDI HEGYGQTETV LICGNFKGMK IKPGSMGKPS
PGYDVKIIDE NSNILPPGKE GDIAIRVKPT RSLFLFTCYA DDPQKTEATI RGDFYVTGDR
GIMDEDGYFW FVGRADDVIN SAGYRIGPFE VESALVEHPA VVESAVVSSP DPIRGEVVKA
FVVLTSDYAS HDPEKMMKEL QDHVKKVTAP YKYPRKMEFV QQLPKTISGK IRRNELRQKE
WKK
//
