ID A0A091VE17_NIPNI Unreviewed; 933 AA.
AC A0A091VE17;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Complement component C6 {ECO:0000313|EMBL:KFR01354.1};
DE Flags: Fragment;
GN ORFNames=Y956_04447 {ECO:0000313|EMBL:KFR01354.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFR01354.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFR01354.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFR01354.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; KL410950; KFR01354.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091VE17; -.
DR STRING; 128390.A0A091VE17; -.
DR eggNOG; ENOG502QPIM; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 3.30.60.30; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR InterPro; IPR048828; C6_KAZAL.
DR InterPro; IPR048831; C8A_B_C6_EGF-like.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF4; COMPLEMENT COMPONENT C6; 1.
DR Pfam; PF21288; C6_KAZAL; 1.
DR Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00084; Sushi; 2.
DR Pfam; PF00090; TSP_1; 3.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00057; FIMAC; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50923; SUSHI; 2.
DR PROSITE; PS50092; TSP1; 3.
PE 3: Inferred from homology;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..933
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001881354"
FT DOMAIN 175..521
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 641..700
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 701..763
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 145..163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 157..172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 671..698
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFR01354.1"
FT NON_TER 933
FT /evidence="ECO:0000313|EMBL:KFR01354.1"
SQ SEQUENCE 933 AA; 104593 MW; 92BFDE3B6A513361 CRC64;
DKTMLMHLVL LSLVIGSSQG CYCEHYPWGS WSACTQTCNY GTQTRHRQIR MDDYYSQNFC
DQLCTKQESR VCNQQTCPIN CRLGDFGPWS ECDPCIKKQF RVRTLLQPSQ FGGQACTEPL
VDSRPCFPTK LCNIVEVDCK NKFQCETGRC IAKKLECNGE NDCGDNSDER NCGRKKMVCN
RKYESIPGVQ LIGSGFHILA RESRGEVLGN SFNGGQCTTV KRNETRKSYR VPANLEAVSF
QVIDEEDDVT SDFYNDLTPL SDSAHGSSSS NHGSQRSSGI PFLFSRKRRI KVTSFSSFKK
AIEASYEKNS NFIRVHKVIS VANFTMKQSD LQLSDVFLKA LNHLPLEYNY ALYSRIFDDF
GTHYYTSGKM GGSYDILYQY SSEELKNSGL TVDESTECVR TETTRRVFFR KKKKVSTRCT
TNRMTVKHEG SILESSERSV SLVKGGRSEY AAALAWEKKG TFPGHTVFTN WLESTKDNPV
VVDFEVSPIV DLVKNVPCAV TKRRNLRRAL REYVGRFDPC QCAPCPNNGR PVLSGTECLC
LCQAGTYGKN CETRAPGYKS VAVDGRWGCW SEWSSCDASF KTRRTRECNN PSPMNGGKPC
EGEREEEEDC YVSVFVDRGA PCINDDEARR EKDILIGEPE SGCSRPDPPE NGFIRNEKNQ
YAVGEEVEIA CVSGHVLSGY QFLRCLPDQT WTQQPVECQP SVCIRPPTSD SVTISPFKQQ
YNIGETVKLS CRAGFRVTGQ TQYTCGKDLS WIPPILKSIT CEKDMQTKIR GVCNPGQKQV
GSQCVCMSPE KACGHYSDDI CVLHAVSEQN VTKPSCQYSA EMCLGEQSFL FLHAGPCHGD
SNLDWAIERA KLSTNSLKKV PCGYDICYDW EECPETQTQC SCLMPYQCPK EESGLHCIQM
EGTGRRRTVS HCTLAAMKCA GIKLEVLEQG SCL
//