ID A0A091VG04_NIPNI Unreviewed; 1186 AA.
AC A0A091VG04;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 {ECO:0000313|EMBL:KFR02049.1};
GN ORFNames=Y956_05446 {ECO:0000313|EMBL:KFR02049.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFR02049.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFR02049.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFR02049.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel HCN family.
CC {ECO:0000256|ARBA:ARBA00006305}.
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DR EMBL; KL411005; KFR02049.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091VG04; -.
DR eggNOG; KOG0498; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013621; Ion_trans_N.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF4; POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08412; Ion_trans_N; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW cAMP {ECO:0000256|ARBA:ARBA00023149};
KW cAMP-binding {ECO:0000256|ARBA:ARBA00022566};
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022566};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 236..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 568..683
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1070
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1186 AA; 129164 MW; E8857C42746A5221 CRC64;
MDKLPPSMRK RLYSLPQQIG PKASIMDEEE DSDKDTRRKS IRLKPLPSPS AGSTRALGGD
PGRGGDPGLL ETEAGSKGAK TSTNGDCRRF KGSLSSLTSR HLHDAAEEKR LIGGEGEPAS
PSEDKSPLGS GELEQGLPAP AAPASPPEPQ QQPHRACSST SIKVEGGGGC DQITPDEEQR
LGQAGFMQRQ FGAMLQPGVN KFSLRMFGSQ KAVEREQERV KSAGFWIIHP YSDFRFYWDL
TMLLLMVGNL IIIPVGITFF KDENTTPWIV FNVVSDTFFL IDLVLNFRTG IVVEDNTEII
LDPQRIKMKY LKSWFVVDFI SSIPVDYIFL IVETRIDSEV YKTARALRIV RFTKILSLLR
LLRLSRLIRY IHQWEEIFHM TYDLASAVVR IVNLIGMMLL LCHWDGCLQF LVPMLQDFPD
DCWVSLNRMV NDSWGKQYSY ALFKAMSHML CIGYGQQAPV GMSDVWLTML SMIVGATCYA
MFIGHATALI QSLDSSRRQY QEKYKQVEQY MSFHKLPADM RQRIHDYYEH RYQGKMFDEE
SILGELSEPL REEIINFNCR KLVASMPLFA NADPNFVTSM LTKLRFEVFQ PGDYIIREGT
IGKKMYFIQH GVVSVLTKGN KETKLADGSY FGEICLLTRG RRTASVRADT YCRLYSLSVD
NFNEVLEEYP MMRRAFETVA LDRLDRIGKK NSILLHKVQH DLNSGVFNYQ ENEIIQQIVQ
HDREMAHCAH NVQAAAAAAA AAASTPTPVI WTPLIQAPLQ AAAATTSVAI ALTHHPRLPT
AIFRPPVSVL GSLGQQSNQT PRQLKRLQSL IPSTGPSAVG SPSSTPSQLH TPGAETPSSS
SFHIQQLAGF SAAAGLGQFQ VGSPPSGSSQ PAQPMQQQQQ QQQPALSSSG FGHFQQATTS
SPSTSLTQLS SNSPPSLLNQ FQPTTRSLQG GQLQQLSGSG TLGGMNQFQP PPSSNSPSSS
LSQLAQASGG PSSGLCQTHP SALGSLTGTI AQLHQERPPF ASMSPLQQSG VASPCYTPSG
LSPPSQSPVA TRTFQCGPSG ASGSHGSLLL PQTASPPPQI LQSKSTPPVP PGRLSQDIKL
ISASQPSLPQ ELAQTLSQSS PHSSRESVSS FSPFPGGGTG LLGKPCSSIP GRVTLPRQMS
SGSLPHPLVF GASAAGAASL TAGGRKESIV LKGDLEPVRS KLPSNL
//
