ID   A0A091VIJ6_NIPNI        Unreviewed;       884 AA.
AC   A0A091VIJ6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=dipeptidyl-peptidase IV {ECO:0000256|ARBA:ARBA00012062};
DE            EC=3.4.14.5 {ECO:0000256|ARBA:ARBA00012062};
DE   Flags: Fragment;
GN   ORFNames=Y956_09676 {ECO:0000313|EMBL:KFR02545.1};
OS   Nipponia nippon (Crested ibis) (Ibis nippon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC   Nipponia.
OX   NCBI_TaxID=128390 {ECO:0000313|EMBL:KFR02545.1, ECO:0000313|Proteomes:UP000053283};
RN   [1] {ECO:0000313|EMBL:KFR02545.1, ECO:0000313|Proteomes:UP000053283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFR02545.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a
CC         polypeptide, preferentially when Yaa is Pro, provided Zaa is neither
CC         Pro nor hydroxyproline.; EC=3.4.14.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001257};
CC   -!- SIMILARITY: Belongs to the peptidase S9B family. DPPIV subfamily.
CC       {ECO:0000256|ARBA:ARBA00010036}.
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DR   EMBL; KL411013; KFR02545.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091VIJ6; -.
DR   STRING; 128390.A0A091VIJ6; -.
DR   MEROPS; S09.018; -.
DR   eggNOG; KOG2281; Eukaryota.
DR   Proteomes; UP000053283; Unassembled WGS sequence.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR045785; Dpp_8/9_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF98; DIPEPTIDYL PEPTIDASE 8; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF19520; Dpp_8_9_N; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053283}.
FT   DOMAIN          1..148
FT                   /note="Dipeptidyl peptidase 8 /9 ,N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19520"
FT   DOMAIN          161..580
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          673..876
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFR02545.1"
FT   NON_TER         884
FT                   /evidence="ECO:0000313|EMBL:KFR02545.1"
SQ   SEQUENCE   884 AA;  101567 MW;  1F5863C6974BF254 CRC64;
     CNMAAAMETE QPGLEIFETA GREEQVQREE QPKLEPFYVE RHSWSQLRKL LTDTRKYHGY
     MMAKAPHDFT FVKKNDPEGP HSDRIYYLAM SGENRENTLF YSEIPKTINK AAVLLLSWKP
     LLDLFPAILD YGMYSREEEL LRERKRIGTV GIASYDYHRE SGTFLFQAGS GIYHVKDGGP
     HGFTQQPLRP VLVETSCPNI RMDPKLCPAD PNWIAFIHSN DIWISNIETR EERRLTFVHN
     ELANVEEDPK SAGVATFVLQ EEFDRYTGYW WSPKAQPTLN GGKVLRILYE ENDESEVEII
     HVTSPMLETR RTDSFRYPKT GTANPKVTFK ISEVTINAEG RIADVVDKEL VQPFEILFEG
     VEYIARAGWT PEGKYIWSIL LDRSQTRLQI VLIPPALFIP TEDDAMERQK LINAVPDSVT
     PFIIYEETTD IWINIHDIFY VFPQTHEDEI EFIFASECKT GFRHLYKVIS VLKESKYKRS
     CGGLPAPSDF KCPVKEEIAI TSGEWEVLGR HGSNIYVDEA KKLVYFQGTK DSPLEHHLYV
     VNYENPGEVK RLTERGYSHA CCVSQDCDMF ISKYSNQKNP HCVSLYRLTG PEDDAAHRTK
     EFWATILDSA GPLPDYIPPE VFSFESSTGF TLYGMMYKPH NLQPGKKYPT VLFIYGGPQV
     QLVNNRFKGI KYFRLNTLAS LGYVVVVIDN RGSCHRGLKF EGAFKYKMGQ IEIDDQVEGL
     QYLASQYDFI DLDRVGIHGW SYGGYLSLMA LMQRSDIFRV AIAGAPVTLW IFYDTGYTER
     YMGHPDHNEQ GYYLGSVAMQ AEKFPSEPNR LLLLHGFLDE NVHFAHTSIL LSFLVRAGKP
     YDLQIYPQER HSIRVPESGE HYELHLLYYL QENLGSRIAA LKAM
//