ID A0A091VIL3_NIPNI Unreviewed; 2023 AA.
AC A0A091VIL3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE Flags: Fragment;
GN ORFNames=Y956_09697 {ECO:0000313|EMBL:KFR02565.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFR02565.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFR02565.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFR02565.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; KL411013; KFR02565.1; -; Genomic_DNA.
DR STRING; 128390.A0A091VIL3; -.
DR eggNOG; KOG0192; Eukaryota.
DR eggNOG; KOG0619; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR CDD; cd14067; STKc_LRRK1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032171; COR.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR020859; ROC_dom.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR48055; LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1; 1.
DR PANTHER; PTHR48055:SF13; LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 1; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF08477; Roc; 1.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS51424; ROC; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFR02565.1};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFR02565.1}.
FT DOMAIN 646..840
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
FT DOMAIN 1256..1539
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1857..1889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1857..1887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFR02565.1"
FT NON_TER 2023
FT /evidence="ECO:0000313|EMBL:KFR02565.1"
SQ SEQUENCE 2023 AA; 226464 MW; A925DF44281F5989 CRC64;
PRMYWCVGTE ESAICRESNM DPQNGTVDMG GKQSTVGEVS IIQTPVTESI QDAYKAGDTS
KAQELIKLSC EEAALQVEKC QLLGIAAAYG DLQAVRYLLK EALVVLPTEP NDDNAAVVAA
YFGHKDVVKE LLDSLHGKPI GLPLPFLKLV VKCRIFSVGP STCQQLLNWM LAIACQQGHL
DVVKLLIRAY SADPESCAVR KNEFPVLIRL PLYAAIKAGN EDVAVFLLRN GAFFCSYILM
DSPESSKHLL RKYFIETSPL PGSAPAKTAL CVNWSNLKLP WVDLDWLIDI SCQITELDLS
ANCLVSLPSV IPWGLINLRK LSLADNQLTE LPSVQSSDEI ICTRLLEVDV SSNRLSTLPS
GFLHLKNLKK LIAAKNYMEK LFDEENTTNW IGLRKLQEFD VSDNRLVELP TVFLYCFKSL
NILNVSRNQL KVFPDPWACP LKCCKASRNS LEFLPDALTI FWKNHLREVD FSENSLKEVP
PGLFQLEALV SLKLLGNQLV TLPSQDKWNC KQLKSLDLSK NQLGKSDEGF KTKRIPFFTT
KNRVRCGPEA GPFLEFPAFL SDSLEVLYLN DNQLDSVPQS VCLLKGLTEL YLGNNPGIRE
LPPELGQLAN LWQLDIEELN ISNVPAEIRK EGPKTVLAYL RAQLRKAEKC KLMKMIIIGP
PRQGKSTLIE ILQTGKVPQM MHSDATIRTT KWELPKPVGH KAKVDSVEFN VWDIGGPASM
STVNQCFFTD KALYIVVWNL ALGEEAVANL QFWLLNIEAK APNSVVLVVG THLDLIETKF
RVERIATLRA YVLALCRSPS GSRATGFPDI TFKHLHELSC KTLEGLDGLR QLIFHVTCNM
KDVGSSICSQ KLAGRLIPRS YLSLQEAVLA EQHRRSQNDD VQYLTDRQIE LIIEQTPGND
IKDYEDLQTA INFLIETGTL LHFPDTSHGL RNLYFLDPVW LSECLQRIFN IKSSKSIAKN
GVIRAEDLRM LLVGTGFTEQ TEEQYFQFLA KFEIALPVAN NSYLLPHLLP TKPALDIHGL
CHQTTNTVQR VFKMSFVPVG FWQRFIARML ISLAEMDLQL FENKKNTKTR NKKVTIYSFT
GTQRNRCSTF RVKRTHTVYW QEGLFVTFDG GYLSVESSDV NWKKKKSGGI KIICQSEVRD
FSAMAFITDH VNSLIDQWFP ALTATESDGT LLMEQYVPCH ICAASKPEEN ECGEKAEDAQ
YFNMEDCVLT AIELDYITCP NHPDIPVSLQ ELVPELFMTD FPARLFLENS KLECSENENN
VLGQGGSGTV IYRARYQGKP VAVKRFQIKK CKGSPTSAAD TMLKHLRAMD AMKNFSEFRQ
EASMLHSLQH PCIVSLIGIS IHPLCFALEL APLGSLTTVL SENSKGSSFV PLGHMLTHKI
AYQIVTGLAY LHKKNIIFCD LKSDNILVWS LDVKEHINIK LSDYGISRQS FHEGALGVEG
TPGYQAPEIR PRIVYDEKVD MFSYGMVLYE LLSGQRPVLG QHQLQIAKKL SKGIRPVLGQ
PEEVQLYRMQ ALMMECWDTK PEKRPLAISV VGQMKDPTFA TFMYLLSCGK QSSFFCSQGQ
EYTVVFWDGK EDTRNYTVVN PEKGVIEVER MSCPGMKLCC QLKFQNALWA ATEDQKISVY
GLQGMCPLKT PQKGLDTPAT VSCFLVMPVV KKNSYVVLAG LSDGLVAVFS VSQGIPGDSC
SYLCSHTANR SKFNISDDDP RQNPYPVKAM EITNSGAEVW YSNGPGILII DCATMEISRR
LEPFSPPSVI TSIACNSECH GEEVVWCLDD KSNFLVMYHV TTYQLCARYF CGDCSPLRDM
FTIQQPSAAI PATAPINHKA MESNPLADMS IIYSPEVGTQ ILNHQDSLTD YCSVSSYSSS
PPNRITRCPS SLPSSPMSSS SAPFSTDFEE SDKFHELKPP LHHDAMPAGD NTQHLQAVKI
LPVKDLIWIP RRGGDIIVIG LEKESGTQRG RVIAVLKAGE LAPYGTLVDA ALIGKDTVVC
CFENENMEWC LAVWRGWSAR DFDVFYQAYE ELGRLETCMR KRR
//
