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Database: UniProt
Entry: A0A091VKR7_NIPNI
LinkDB: A0A091VKR7_NIPNI
Original site: A0A091VKR7_NIPNI 
ID   A0A091VKR7_NIPNI        Unreviewed;      1331 AA.
AC   A0A091VKR7;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE   Flags: Fragment;
GN   ORFNames=Y956_04637 {ECO:0000313|EMBL:KFR03987.1};
OS   Nipponia nippon (Crested ibis) (Ibis nippon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC   Nipponia.
OX   NCBI_TaxID=128390 {ECO:0000313|EMBL:KFR03987.1, ECO:0000313|Proteomes:UP000053283};
RN   [1] {ECO:0000313|EMBL:KFR03987.1, ECO:0000313|Proteomes:UP000053283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFR03987.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC       protein kinase family. {ECO:0000256|ARBA:ARBA00009903}.
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DR   EMBL; KL411188; KFR03987.1; -; Genomic_DNA.
DR   STRING; 128390.A0A091VKR7; -.
DR   eggNOG; KOG0612; Eukaryota.
DR   Proteomes; UP000053283; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0007266; P:Rho protein signal transduction; IEA:UniProtKB-UniRule.
DR   CDD; cd20874; C1_ROCK1; 1.
DR   CDD; cd11639; HR1_ROCK1; 1.
DR   CDD; cd01242; PH_ROCK; 1.
DR   CDD; cd22250; ROCK_SBD; 1.
DR   Gene3D; 1.20.5.340; -; 1.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.20.5.730; Single helix bin; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR000961; AGC-kinase_C.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR011072; HR1_rho-bd.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR020684; ROCK1/ROCK2.
DR   InterPro; IPR037310; ROCK1_HR1.
DR   InterPro; IPR015008; ROCK_Rho-bd_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR22988; MYOTONIC DYSTROPHY S/T KINASE-RELATED; 1.
DR   PANTHER; PTHR22988:SF73; RHO-ASSOCIATED PROTEIN KINASE; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF08912; Rho_Binding; 1.
DR   PIRSF; PIRSF037568; Rho_kinase; 1.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00133; S_TK_X; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   SUPFAM; SSF103652; G protein-binding domain; 1.
DR   SUPFAM; SSF90257; Myosin rod fragments; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   PROSITE; PS51860; REM_1; 1.
DR   PROSITE; PS51859; RHO_BD; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW   ProRule:PRU01207}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFR03987.1};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          46..308
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          311..379
FT                   /note="AGC-kinase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51285"
FT   DOMAIN          454..531
FT                   /note="REM-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51860"
FT   DOMAIN          924..990
FT                   /note="RhoBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51859"
FT   DOMAIN          1095..1294
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          1205..1260
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   REGION          1305..1331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          400..887
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          913..958
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          992..1075
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   ACT_SITE        168
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037568-1"
FT   BINDING         75
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037568-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU10141"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFR03987.1"
FT   NON_TER         1331
FT                   /evidence="ECO:0000313|EMBL:KFR03987.1"
SQ   SEQUENCE   1331 AA;  156145 MW;  F67E69C873F3AB13 CRC64;
     QDGLDALVYD LDFPALRKNK NIDNFLNRYK DTVNKMRDLR MKAEDYEVVK VIGRGAFGEV
     QLVRHKSSRR VYAMKLLSKF EMIKRSDSAF FWEERDIMAF ANSPWVVQLF YAFQDDRYLY
     MVMEYMPGGD LVNLMSNYDV PEKWARFYTA EVVLALDAIH SMGFIHRDVK PDNMLLDKAG
     HLKLADFGTC MKMNKEGMVR CDTAVGTPDY ISPEVLKSQG GDGYYGRECD WWSVGVFLYE
     MLVGDTPFYA DSLVGTYSKI MNHKNSLTFP DDNEISKEAK NLICAFLTDR EVRLGRNGVE
     EIKRHLFFKN DQWAWETLRD TVAPVVPDLS SDIDTSNFDD LEEDKGEEET FPIPKAFVGN
     QLPFVGFTYY SNRRYVCRKQ ANGFLNLMHV LSCTNIYLKL ENMQKMIYEL EEQLHNEMQL
     KDEMEQKCRS SNIKLDKIMK ELDEEGNQRK NLESTVSQIE KEKMVLQHKI NDYQRKIEQE
     NEKRRNVENE VSTLKDQMED LKKISQHSQI TNEKITQLQK QLEEANDLLR TESDTAARLR
     KGNTEMSKSL SQVESLNREL QERCRVLEST KLQVEKDYYQ LQAALESERR DRSHGSEMIG
     ELQVRITTLQ EEVKHIKNNL ERVEAERKQA QDMLNHSEKE KNNLEIDLNY KLKSLQDRLE
     QEVNEHKVTK ARLTDKHQSI EEARSVAMCE MEKKVKEERA AREKAENRIV QAEKQCSMLD
     FDLKQSQQKL EHLLEQKERL EDEVKNLTLQ LEQETNKRIM AQNELKAQAF EADNLKGSEK
     QLKQEINTLL EAKRLLEFEL AQLAKQYRGN EGQMRELQDQ LEAEQYFSTL YKTQVKELKE
     EIDEKNKETQ RKTQELQNEK ETLTTQLDLA ETKAESERLA RALLEEQYFE LSQESKKAAS
     RHRQEMTDKD SIIRRLEETN NTLTKDVDLI TKENSEISEK IKKQEEEYKM KKEEEINNIR
     MHYEKSLNTE RTLKTQAVNK LAEIMNRKDF KIDRKKANMQ DLRKKEKENR KLQLELNQEK
     EKFNQMVVKY QKEVNEMQAQ LAEESTYRNE LQMQLDSKES DIEQLRRKIL DLQQGMDSTS
     VASLQPDEID GNLSESRLEG WLSVPNKGNI KRHGWKKQYV VVSSKKILFY NDEKDKDQSN
     PSMVLDIDKL FHVRPVTQGD VYRAETEEIP KIFQILYANE GECRKELEVE PVQPAEKTNF
     LNHKGHEFIP TLYHFPANCE ACAKPLWHVF KPPAALECRR CHVKCHRDHL DKKEELIAPC
     KVSYDVTSAR DMLLLASCQD EQKKWVTHLV KKIPKTPPST FVRASPRTMS TRSSANQSFR
     KVVKNTSGKT R
//
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