ID A0A091VLL9_NIPNI Unreviewed; 706 AA.
AC A0A091VLL9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044};
DE EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044};
DE Flags: Fragment;
GN ORFNames=Y956_15048 {ECO:0000313|EMBL:KFR03590.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFR03590.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFR03590.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFR03590.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC type II family. {ECO:0000256|ARBA:ARBA00005910}.
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DR EMBL; KL411121; KFR03590.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091VLL9; -.
DR STRING; 128390.A0A091VLL9; -.
DR eggNOG; KOG0565; Eukaryota.
DR eggNOG; KOG4270; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052745; F:inositol phosphate phosphatase activity; IEA:InterPro.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09093; INPP5c_INPP5B; 1.
DR CDD; cd04380; RhoGAP_OCRL1; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR048869; OCRL-1_2_ASH.
DR InterPro; IPR037793; OCRL1/INPP5B_INPP5c.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR047078; RhoGAP_OCRL1.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF163; TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF21310; OCRL-like_ASH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283}.
FT DOMAIN 523..706
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFR03590.1"
FT NON_TER 706
FT /evidence="ECO:0000313|EMBL:KFR03590.1"
SQ SEQUENCE 706 AA; 80941 MW; 7AA9D7660645CB63 CRC64;
QNKLKPELTT EMVRSSSVMV SNKASILSEP KFGLRDTIVK SQLVQMEDSY THIQSFRFFV
GTYNVNGQSP RESLQPWLRC DAEPPDIYCV GFQELDLSKE AFFFNDTPKE EEWFKAVTDS
LHPDAKYAKV KLVRLVGIML LLYVRADLAL NISEVEIETV GTGIMGRMGN KGGVAIRFKF
HNTSVCIVNS HLAAHTEEYE RRNQDFKDIC SRMQFCQSDP NLPPLTIGKH DVILWLGDLN
YRLEELDVAK VKQLVDERAF LELCQYDQLK RQMNANAVFE GFTEGEISFQ PTYKYDAGCD
DWDTSEKCRV PAWCDRILWK GQNIAQLSYR SHMALKISDH KPVSSVFDIG VKVVNEELYR
KAFEEIVRSL DKLENANIPS VTLSQREFHF EDVKYMQLQV EKFTIRNGPV PCQFEFISKP
DEETYCKEWL IANPSKGFLL SDAEITVELE VFVNKSTATR LNSGEEKLED ILVLHLNRGK
DYFLSVTGNY LPSCFGSPIH TLCYMREPIQ DMSAESIQKL TLMPLEMSDD AVQAEKPMDI
PKELWMMVDH LYRNASQQED LFQQPGLRSE FEQIRDCLDK GMHDTLLGSN HSVAEALLLF
LESLPEPVIC YRLYSSCLEC ASNYLLSSQL ISNLPGCHKN VFEYLMAFLR ELLKNSGKNH
LDVNILASIF GGLLLRPPPG HPTPDITEKR KAQQFIHQFL LREDNL
//
