ID A0A091VM93_NIPNI Unreviewed; 491 AA.
AC A0A091VM93;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=[histone H3]-lysine(4) N-trimethyltransferase {ECO:0000256|ARBA:ARBA00012182};
DE EC=2.1.1.354 {ECO:0000256|ARBA:ARBA00012182};
GN ORFNames=Y956_09980 {ECO:0000313|EMBL:KFR04522.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFR04522.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFR04522.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFR04522.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) +
CC N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60260, Rhea:RHEA-COMP:15537, Rhea:RHEA-
CC COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.354;
CC Evidence={ECO:0000256|ARBA:ARBA00000944};
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DR EMBL; KL411211; KFR04522.1; -; Genomic_DNA.
DR RefSeq; XP_009469960.1; XM_009471685.1.
DR AlphaFoldDB; A0A091VM93; -.
DR STRING; 128390.A0A091VM93; -.
DR GeneID; 104018532; -.
DR KEGG; nni:104018532; -.
DR CTD; 150572; -.
DR eggNOG; KOG2084; Eukaryota.
DR OrthoDB; 166337at2759; -.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0042800; F:histone H3K4 methyltransferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd10526; SET_SMYD1; 1.
DR Gene3D; 1.10.220.160; -; 1.
DR Gene3D; 1.25.40.970; -; 1.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044418; SMYD1_SET.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR12197; HISTONE-LYSINE N-METHYLTRANSFERASE SMYD; 1.
DR PANTHER; PTHR12197:SF184; HISTONE-LYSINE N-METHYLTRANSFERASE SMYD1; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:KFR04522.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW Transferase {ECO:0000313|EMBL:KFR04522.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 7..253
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 52..90
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
SQ SEQUENCE 491 AA; 56128 MW; 097086E4D9E88591 CRC64;
MTKGGMESVE VFTSEGKGRG LKAQKEFLPG DVIFAEPAYA AVVFDSLTHV ICHTCFKRQE
RLHRCGQCKF AYYCDRTCQR AAWLNHKNEC SAIKKHGKAP TENIRLAARI MWKIEREGSG
LAEGCLVSID DLQNHVDSFD EEEKKELRAD VESFLEFWPP QSQQFGMQYI SHIFGVISCN
GFTLSDQRGL QAVGVGIFPN LCQANHDCWP NCTVIFNNGN HEAVRSMFHT QMRIELRALT
KISPGDELTV SYVDFLNVSE ERRKQLKKQY YFDCTCEHCK KQIKDDLMLA VKQGEGKPSA
ETVKEVIQFS KDTLEKINKA RMEGLYHEVV KMCRECLKKQ EPVLGDTNIY LLRILSIASE
VLSYLQMFEE AADYAKRMVD GYLKIYHPNN AQLGMAVMRA GVTHWHAGLI EAGHGLICKA
YAILLITHGP SHPITKDLEV MRVQTEMELR MFQQNELMYY KMREAALKNQ KIQVMPEPSN
ETSPSLFHKK E
//
