ID A0A091VV91_NIPNI Unreviewed; 1885 AA.
AC A0A091VV91;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Low-density lipoprotein receptor-related protein 4 {ECO:0000313|EMBL:KFR07277.1};
DE Flags: Fragment;
GN ORFNames=Y956_16670 {ECO:0000313|EMBL:KFR07277.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFR07277.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFR07277.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFR07277.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; KL411414; KFR07277.1; -; Genomic_DNA.
DR STRING; 128390.A0A091VV91; -.
DR eggNOG; KOG1215; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00058; Ldl_recept_b; 15.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 5.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 16.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:KFR07277.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KFR07277.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1705..1726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 401..416
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 463..505
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 506..548
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 549..592
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 593..635
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 768..810
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 811..853
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 854..897
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 898..940
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1076..1118
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1119..1161
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1162..1205
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1206..1247
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1380..1422
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1423..1465
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1466..1509
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1510..1551
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 1633..1675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1831..1885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1645..1674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1831..1864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1868..1885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 34..49
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 54..66
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 61..79
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 73..88
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 93..105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 100..118
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 131..143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 138..156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 150..165
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 174..186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 181..199
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 193..208
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 214..226
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 221..239
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 233..248
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 253..265
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 260..278
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 272..287
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 295..307
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 302..320
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFR07277.1"
FT NON_TER 1885
FT /evidence="ECO:0000313|EMBL:KFR07277.1"
SQ SEQUENCE 1885 AA; 210220 MW; AD640718244F8807 CRC64;
GVTSSTECSC GRNHFTCAVS AFGECTCIPA QWQCDGDNDC GDHSDEDGCM LPTCSPLDFH
CDNGKCIRRS WVCDGDNDCE DDSDEQDCPP RECEEDEFSC QNGYCIRSLW HCDGDNDCGD
NSDEQCDMRK CSEKEFRCSD GSCIAEHWFC DGDTDCKDGS DEENCPSDVP AATCSLEEFQ
CAYGRCILDI YHCDGDDDCG DWSDESDCSS HQPCRSGEFM CNSGLCINAG WRCDGDFDCD
DQSDERNCTT SMCTADQFRC KSGRCVRLSW RCDGEDDCSD NSDEENCENT GTPQCAPDQF
LCGNGRCIGQ RKLCNGANDC GDGSDESPHQ NCRPRTGEEN CNVNNGGCAQ KCQMVRGMVQ
CTCHTGYRLL EDGRSCQDVN ECAEEGYCSQ GCTNSEGGFQ CWCEQGYELR PDKRSCKALG
PEPVLLFANR IDIRQVLPHR SEYTLLLNNL ENAIALDFHH SKELVFWSDV TLDRIMRANL
NGSNVEEVVS TGLESPGGLA IDWIHDKLYW TDSGTSRIEV ANLDGTHRKV LLWQNLEKPR
AIALHPMEGT IYWTDWGNTP RIEYSNMDGS NRRIIADTHL FWPNGLTIDY AGHRMYWVDA
KHHVIERADL DGRNRKAVIS QGLPHPFAIT VFEDSLYWTD WHTKSINSAN KFTGKNQEII
RNKLHFPMDI HTLHPQRQPA GRNRCGANNG GCTHLCLPSS KDYTCACPTG FRKTSSHACA
QSLDKFLLFA RRMDIRRISF DTDDLSDDVI PLADVRSAVA LDWDSKDDYV YWTDVSTDSI
SRAKWDGSSQ EVVVDTSLES PAGLAIDWVT NKLYWTDAGT DRIEVSNTDG TMRTVLIWEN
LDRPRDIVVD PVGGFMYWTD WGASPKIERA GMDASNRLVI ISSNLTWPNG LAIDYESQCL
YWADAGMKTI EYASLDGSNR KVLIGSNLPH PFGLTLYGER IYWTDWQAKS IQSADRRTGQ
ARETLQDNLE NLMDIHVFHR HRPPVHTACE VSNGGCSHLC LLAPLPKGYS CTCPTGINLQ
SDGKTCSPGM TSFLIFARRT DIRMVSLDIP YFADVVVSVN VTMKNTIAIG VDPHEGKVYW
SDSTLRKISR AALDGSQFED IITTGLLTTD GLAVDAIGRK IYWTDTGTNR IEVGNLDGSM
RKVLVWQNLD SPRAIALYHE MGYMYWTDWG ENAKLERSGM DGSGRAVLIS NNLGWPNGLA
VDKAGSQLLW ADAHTERIEA ADLNGANRRT LLSPVQHPYG LTLLDSYIYW TDWQTRSIHR
ADKDTGANVI LVRANLPGLM DIQAVDRARP LGFNKCRVRN GGCSHLCLPH PTGFSCACPT
GIQLKRDEQT CDSSPETYLL FSSRASIRRI SLDTSDHTDV HIPVPELNNV ISLDYDSVDG
KIYYTDVFLD VIRRSDLNGS NMETVIGQGL KTTDGLAVDW VARNLYWTDT GRNTIEVARL
DGSSRKVLIN NSLDEPRAIA VFPKKGYLFW TDWGHIAKIE RANLDGSERK ILINTDLGWP
NGLTLDYDTR RIYWVDAHLD RIESCDLNGK LRQVLVSQVS HPFALTQQDR WIYWTDWQTK
SIQRVDKYSG RNKETVLANV EGLMDIIVVS PQRQTGTNAC GVNNGGCTHL CFARASDFVC
ACPDEPDGRP CSTIPGVVPP GPEPTSVSER SQTPRGRVDT STTKPLTSLE SAEGNCSDKD
ARRGLCTHAN EAVLATMGEG LHVSYIIGGL LSILFILLLI AALIIYRHNK SKFTDPGLGN
LTYSNPSYRT STQEVKIEAI PKPTMYNQLC YKKETGPDHS YTKEKIRIVE GICLLSSDDS
EWDDLKQIRS SRGGILRDHV CMKTDTVSIQ ASSGSLDDTE TEQLLQEEQS ECSSVNTTAA
TPERRGSLPD TGWKHQRKPS TESEV
//
