ID A0A091W2S6_OPIHO Unreviewed; 1191 AA.
AC A0A091W2S6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=N306_11607 {ECO:0000313|EMBL:KFR09083.1};
OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC Opisthocomus.
OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR09083.1, ECO:0000313|Proteomes:UP000053605};
RN [1] {ECO:0000313|EMBL:KFR09083.1, ECO:0000313|Proteomes:UP000053605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR09083.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649}.
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DR EMBL; KK734505; KFR09083.1; -; Genomic_DNA.
DR RefSeq; XP_009931124.1; XM_009932822.1.
DR AlphaFoldDB; A0A091W2S6; -.
DR STRING; 30419.A0A091W2S6; -.
DR GeneID; 104327868; -.
DR KEGG; oha:104327868; -.
DR CTD; 5784; -.
DR OrthoDB; 3108587at2759; -.
DR PhylomeDB; A0A091W2S6; -.
DR Proteomes; UP000053605; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13188; FERM_C_PTPN14_PTPN21; 1.
DR CDD; cd17191; FERM_F1_PTPN14; 1.
DR CDD; cd14599; PTPc-N14; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR014392; PTP_non-rcpt_14/21.
DR InterPro; IPR041782; PTPN14/21_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF6; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 14; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PIRSF; PIRSF000934; Tyr-Ptase_nr14; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Receptor {ECO:0000313|EMBL:KFR09083.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053605}.
FT DOMAIN 21..306
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 913..1184
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1094..1175
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 309..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1125
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
SQ SEQUENCE 1191 AA; 135664 MW; 6E782B44F0729323 CRC64;
MPFGLKLRRT RRYNVLSKNC FVTRIRLLDS NVIECTLSVE STGQECLEAV AQRLELRETH
YFGLWFLSKS QQHRWVELEK PLKKQLDKFA NEPLLFFGVM FYVPSVSRLQ QEVTRYQYYL
QVKKDVLDGR LLSSLEQGIR LAGLAVQADF GDYNHFESHD FLREYVLFPM DWTQDEAVLE
ELTQKVAQEH RTHSGIPAAE AELMYINEVE RLDGFGQEIF PVKDNHGNDI HLGIFFMGIF
IKNRIGRKTV IYRWNDIGNI AHNKSSIVLE LINKEENVLF HTDDLENAKY ISRLFAARHK
FYKQNKICTE QSSSPPPIRR RPTWSRSSLP RQHPFILPPM HVQCGEHYTE THNSQDSIFH
GNEETFYCRS QTSLDRCAAD FSYLNGNGPN GSVCSAHSMN SLNRSQNFIQ ASPMSSNLSI
PGSDIMRADY IPSHRHSAII VPSYRPTPDY ETVMRQMKRG VIQMDSQSQS LRNLNIGNTH
AYNQPEDLVY SQPEIRERHP YTITYGPQGG GYNKPVAPSD QMNPNNAVQN KTAASAISHT
VSTPELANMQ LQSSQSYNTA HMLKNYLFRP PPPYPRPRPA TSTPDLASHR HKYVSGSSPD
LVTRKVQLSV KTFQEDSSPV VRQSLQEVSE PLMAVKHHAA VNKRHSLEVI SNMVRGIEAM
ALKTLNAPLP RRNTLREQVQ PEESVQMGHE VQHVPHYHHK KTFSDATMLI HSSESEEEEE
TPESVSRITA LHENMEYSAQ LQAALARIPN KPPPEYPGPR KSVSNGALRQ DHVSISVAVA
RAKAMRPGPS KAISVSRTDQ MAINGSSLGP SISEPDLTSV KERVKKEPVK ERPVSEMFSI
EDSIIEREIM MRNLEKQKMA GLEAQKRPLM LAALNGLSVA RVPVPEDSQD EVAKVPMDER
CKILKRKLEE GMVFTEYEQI PKKKADGIFT TAALPENTER NRIREVVPYE ENRVELVPTK
ENNTGYINAS HIKVTVGGEE WHYIATQGPL PHTCHDFWQM VWEQGVNVIA MVTAEEEGGR
SKSHRYWPKL GSKHSSATYG KFKVTTKFRT DSGCYATTGL KVKHLLSGQE RTVWHLQYTD
WPDHGCPEEV QGFLSYLEEI QSVRRHTNSV LDSSNNCNPP IVVHCSAGVG RTGVVILTEL
MIGCLEHNEK VDVHVMLRHL REQRMFMIQT IAQYKFVYQV LIHFLQNSRL I
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