ID A0A091W330_NIPNI Unreviewed; 431 AA.
AC A0A091W330;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE Flags: Fragment;
GN ORFNames=Y956_16178 {ECO:0000313|EMBL:KFQ96218.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ96218.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFQ96218.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ96218.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-
CC glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00000251,
CC ECO:0000256|RuleBase:RU610713};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC {ECO:0000256|ARBA:ARBA00008871, ECO:0000256|RuleBase:RU610713}.
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DR EMBL; KL410348; KFQ96218.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091W330; -.
DR STRING; 128390.A0A091W330; -.
DR eggNOG; ENOG502QTUU; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR018155; Hyaluronidase.
DR PANTHER; PTHR11769; HYALURONIDASE; 1.
DR PANTHER; PTHR11769:SF9; HYALURONIDASE; 1.
DR Pfam; PF01630; Glyco_hydro_56; 1.
DR PIRSF; PIRSF038193; Hyaluronidase; 1.
DR PRINTS; PR00846; GLHYDRLASE56.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU610713};
KW Hydrolase {ECO:0000256|RuleBase:RU610713};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283}.
FT ACT_SITE 127
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-1"
FT CARBOHYD 349
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-2"
FT DISULFID 39..332
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 203..219
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 357..368
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 362..419
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 421..430
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ96218.1"
FT NON_TER 431
FT /evidence="ECO:0000313|EMBL:KFQ96218.1"
SQ SEQUENCE 431 AA; 49607 MW; EE85B4312D11E579 CRC64;
LAVMALLTVV DAQLPKPARA PLVLHKPFMV VWNAPTEQCR LRYKVDLDLS VFDIASNTNE
TLSGSNVTIF YHTHLGYYPY YSDNGDPVNG GVPQNESLIK HLNKAKSDID YCIPMKKFQG
LAVIDWENWR PQWDRNWGNK SIYRNKSLEM VRRRHPQWSE DKIRKVAKEE FENAGKSFMN
NTILLAEHMR PNGLWGYYLY PDCYNYDYKE HPQTYTGKCP AIESSRNDLL LWLWKESTAL
YPSIYLDYIL KSSPNALKFV HYRVKEAIRV ASIARKDYVL PVFVYSRPFY AYTFHVLTET
DLVNTIGESA ALGAAGVVLW GSMQYASSKE SCSTVKRYID GPLGHYIINV TSAAKLCSKV
LCKKNGRCIR KNSDSSAYLH LSPTNFKIRA RHSERGPRFQ VTGEPSLESI EVMRQRFMCQ
CYQGWTGIFC E
//
