ID   A0A091WA03_OPIHO        Unreviewed;       809 AA.
AC   A0A091WA03;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Two pore calcium channel protein 1 {ECO:0000313|EMBL:KFR12462.1};
GN   ORFNames=N306_12541 {ECO:0000313|EMBL:KFR12462.1};
OS   Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC   Opisthocomus.
OX   NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR12462.1, ECO:0000313|Proteomes:UP000053605};
RN   [1] {ECO:0000313|EMBL:KFR12462.1, ECO:0000313|Proteomes:UP000053605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR12462.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KK735113; KFR12462.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091WA03; -.
DR   STRING; 30419.A0A091WA03; -.
DR   PhylomeDB; A0A091WA03; -.
DR   Proteomes; UP000053605; Unassembled WGS sequence.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:InterPro.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0022832; F:voltage-gated channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 2.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028801; TPC1_animal.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR46474; TWO PORE CALCIUM CHANNEL PROTEIN 1; 1.
DR   PANTHER; PTHR46474:SF1; TWO PORE CHANNEL PROTEIN 1; 1.
DR   Pfam; PF00520; Ion_trans; 2.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        103..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        128..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        169..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        225..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        294..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        469..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        499..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        562..586
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        658..683
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          107..326
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          433..683
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          9..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          773..809
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        783..809
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   809 AA;  93878 MW;  54413EDFD63F9611 CRC64;
     MDDDVPLILT LDDTGSSASA PLDDLEREEL PNENGGSYDV ISDASSPAAG DCCVQQGSAR
     HNWEMNYQEA AIYLQEGENN DKFFTHPKNA KALSAYLFAH NHLFYLMELS TALLLLLLSL
     CEAPAVPMLR LGIFVHATLE LFALIVVVFE LSMKMRWLGF QTFIRHKRTM VKTCVLFVQF
     IEAIVVLVRQ TSHVRITRAL RCIFLVDCRY CGAVRRNLRQ IFQSLPPFID ILLLLLFFMV
     IFAILGFYLF SPNHSDPYFN TLENSLVNLF VLLTTSNFPD VMMPSYARNP WSCVFFIVYL
     SIELYFIMNL LLAVVFDTFN DIEKRKFKSL LLHKRTAIQH AYRLLITRQR PSGISFKHFE
     GLLRFYKPRM CARERYLTFK ALNQSNTPLV SLKDFYNFYE VVGLKWKVRK TKSELPRTAF
     VIFKGINILV KSRVFQYTMY TVVAVNGIWI LVETFMLQGG NFFSRNVPWS YIVFLTIYGV
     ELLLKTTGLG PVEYLSSGWN LFDFSVTLFA FLGLMALAFN MEPFYFIVVL RPLQLLRLFK
     LKKRYRNVLD TMFELFPRMA SLGLTLLIFY YCFAIVGMEF FAGVVYPNCC NTSTVADSYR
     WVNHTVGNKT VVEEGYYYLN NFDNILNSFV TLFELTVVND WYIIMEGVTS QTTHWSRLYF
     MIFYIVTMVV MTIIVAFILD AFVFRMNYTR KNQDSEEDNG IVLEKEISKE EVVGIMELYR
     RSSAATETAQ LQKIVLQMDK YGQMSTLFLG RRSRTKSDLS MKMYEEEIQE WYEEHSRKEE
     SQVPSQEPAS ASNSSLKPLS LRQRSHTVI
//