ID A0A091WDA2_OPIHO Unreviewed; 1350 AA.
AC A0A091WDA2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Nonsense-mediated mRNA decay factor {ECO:0000256|RuleBase:RU369098};
DE Flags: Fragment;
GN ORFNames=N306_10478 {ECO:0000313|EMBL:KFR13672.1};
OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC Opisthocomus.
OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR13672.1, ECO:0000313|Proteomes:UP000053605};
RN [1] {ECO:0000313|EMBL:KFR13672.1, ECO:0000313|Proteomes:UP000053605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR13672.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in nonsense-mediated mRNA decay.
CC {ECO:0000256|RuleBase:RU369098}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369098}.
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DR EMBL; KK735298; KFR13672.1; -; Genomic_DNA.
DR STRING; 30419.A0A091WDA2; -.
DR PhylomeDB; A0A091WDA2; -.
DR Proteomes; UP000053605; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR CDD; cd09885; PIN_Smg6-like; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR InterPro; IPR019458; Est1-like_N.
DR InterPro; IPR045153; Est1/Ebs1-like.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR PANTHER; PTHR15696:SF40; TELOMERASE-BINDING PROTEIN EST1A; 1.
DR Pfam; PF10374; EST1; 1.
DR Pfam; PF10373; EST1_DNA_bind; 1.
DR Pfam; PF13638; PIN_4; 1.
DR SMART; SM00670; PINc; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161,
KW ECO:0000256|RuleBase:RU369098};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU369098};
KW Reference proteome {ECO:0000313|Proteomes:UP000053605}.
FT DOMAIN 1218..1343
FT /note="PIN"
FT /evidence="ECO:0000259|SMART:SM00670"
FT REGION 1..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 546..573
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..311
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFR13672.1"
FT NON_TER 1350
FT /evidence="ECO:0000313|EMBL:KFR13672.1"
SQ SEQUENCE 1350 AA; 152640 MW; 6F91EACCAD8EFF32 CRC64;
ENIKEVKEPR HRKDNRRPDL EIYKPGLSRL RGKLLLPKHE ASEKERGRAE EESTSDKVPS
GGGAPVMEDF GKCDGPRQNG PSQENEETET KGGLQSQENL SKQPAPDEWV PKTTRRTKKP
DQQIYQPGKR LHSAAKEPSL RSATEEVTSK MEQLKVERDE ETEKGTGKDN NRKTKSSKEE
REGSQAGEGA KASRGEKGRR IERSDRIRRT SDEVMRGKLG STKRYSRSDK RRSRYRTCST
SSAGSNNSVD GAPLMDRAER RQERARERTR PRKQLSASST DSLDDDRVDE AEAYVSSRNL
DKKKRSEQSQ ASRSESEWSS NGREVKGPFR VTFDSKTMNR DISLADTDKK KPLKAFVSCN
DSEASEARSQ SREPQGRGPV ILFLPANTDL SASTAGSPEP SHPGPRLLLG GAGSKGPRSR
GRGGTARRLW DPNNPDQKPA LKSQTAQLHF LDTDDEVSPT SWGEARQAQT SYYKFQNSDN
PYYYPRASGQ GPQYPYGGYS LQYPMGPSNG VYPGAYYPGY PGQAGQYVCG PLPPTPLSPE
MEQQMRNMQQ QELSKLLREA GNQEQQLSNL LSRDRISPEG LEKMAQLRAE MLQLYERCIL
MDIEFSDTQN VDQLLWKNAF YQVIEKFRQL LKDPQGENAQ EIRNKLLQLL DEGTSFFDGL
LQKLQVSYQF KLEDYMDGMA IRSKPLRKMV KYALISAQRC MICQGDICRY REQANDTANY
GKARSWYLKA QQIAPKNGRP YNQLALLAIY TRRKLDAVYY YMRSLAASNP ILTAKESLMS
LFEETKRKAE QMEQRKHQVL ELSPSRRCKG KKSTLRQVGD DATRLEIWIH PSHPRSSQSH
ESGRDSEQDN GLGNLSPSDL NKRFILSFLH AHGKLFTRIG METFPAVAEE VLREFQVLLQ
HSPPPIGSTR MLQLVAINMF AVYNSQPKEC VSEDCRSVIQ EQATALGLSM FALLVRRCTS
LLRECVQVQP QEMEQEDEED DIKVSALPQD LKELLPSVKV WSDWMLGYPD TWNPPPTSLE
LPKQVSVDVW ATLADFCNIL TTVNQSEVPL YKDPDDDLAL LSLEEDRLLS GFVPLLVAPQ
EPCYVERTSD KVIAADCKRV TVLKYFLEAL CGQEEPLLAF KGGKYVSVAP VPDAMGKEMG
SQEGKQLEDQ EDDVRIEAFE DDSEAEGSGG EMDIKELRAK KQALARKVAE QQRRQDKIQA
VLKDQSQMRQ MELEIRPVFL VPDTNGFIDH LSSLITLLDC RKFILVVPLI VINELDGLAK
GPEMEHRAAG YARQVQERAR KSIEFLEERF ESRDNCLRAL TSRGNELESI SFRSEDTTGQ
QGNNDDLILS CCLHYCNDKA KDFMPSNKGE
//
