ID A0A091WFM0_OPIHO Unreviewed; 1011 AA.
AC A0A091WFM0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Rho guanine nucleotide exchange factor 28 {ECO:0000313|EMBL:KFR13633.1};
DE Flags: Fragment;
GN ORFNames=N306_03267 {ECO:0000313|EMBL:KFR13633.1};
OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC Opisthocomus.
OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR13633.1, ECO:0000313|Proteomes:UP000053605};
RN [1] {ECO:0000313|EMBL:KFR13633.1, ECO:0000313|Proteomes:UP000053605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR13633.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KK735295; KFR13633.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091WFM0; -.
DR STRING; 30419.A0A091WFM0; -.
DR PhylomeDB; A0A091WFM0; -.
DR Proteomes; UP000053605; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR PANTHER; PTHR13944:SF22; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 28; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 56..103
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 253..449
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 491..593
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 171..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 826..860
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 893..920
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFR13633.1"
FT NON_TER 1011
FT /evidence="ECO:0000313|EMBL:KFR13633.1"
SQ SEQUENCE 1011 AA; 116416 MW; D1B49360EBFEB0C9 CRC64;
RIQEEEWNKY IVPSKNESEK CKVSRTFSFL MNRMTSTRNK CKTKNKDAKD KEKLNRHSFT
NGTFSGVIPC MACEKALLGK ESLQCSHCNM IVHKSCKECA PVCTKVTSYT ALFLPERICF
PSGSLPGDIS QMMLSPVHPS SSVPIGLSAA RREALQQSHF LSKSVPSASF ERRSTPFSEQ
DSETSTWRSK SRSEEMLQAL GTFSSMDPFM MEDDVDLSQW TDLRTDAQEF EAESWSLVVD
PVFCSKQDKD VIKRQDVIFE LMQTEVHHVH TLFIMSEIFR KGMKEELQLD HSTVDRIFPC
LDELLEMHRQ FFCRMKERRQ ESCEAGSERN FVISRIGDIL VQQFSEENAT KMKKIYGEFC
SHQKEAVNLF KELQQNKKFQ NFIKLRNSNL LARRRGIPEC ILLVTQRITK YPVLVERILQ
CSKEGTEEHK DLCKALRLIK DMIAAVDLKV NEYEKKQKLL DILSRTENKT YTKLKNGHVF
RKQDLMKKER ILLHEGLVYW KTATGRFKDT LALLLTDVLL FLQEKDQKYI FAAVDQKPSV
ISLQRLIVRE VANEERGMFL ISASSAGPEM YEVHTNSKEE RNNWMRHIQD AVESCPEEEE
EGKMSESDED RRIAEAKTSR IQKCQESLSN QDQQICSYLE EKLCIYAELG DISGFEDVHV
EPHLLIKPDS GETPQAASLL AAALREVESL HVAVTTSQVS ETDRSPEEST EELSVKHRFS
EIWESVPGGF FFLAAPGRLL HIHSTACNLA SRSALGSMSF PGSTGTEIVQ AIQNLTRLLY
SIQAALAIQD SHRELHRLLL QENEKTGRGH GSRLNILLEQ EKYRNLEKQR VELANIHKLK
QQFQQEQQRW LRECEQRERE QEAREGRLGQ RERECGYQEE LLKRSQHGLV LQLQEYQQSL
ERLQEGQKMV ERERDSVEMQ KKLLWHWKHG RQSSLLSSTG SYEIMGHNQS DTLHGENTFY
LNEAVVCVSL SSLSRSDSSL VYEDGVYGLN ISNSDIARTS ENQVDLEMDT S
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