ID A0A091WFU0_OPIHO Unreviewed; 331 AA.
AC A0A091WFU0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=tRNA methyltransferase 10 homolog C {ECO:0000256|ARBA:ARBA00014681};
DE EC=2.1.1.218 {ECO:0000256|ARBA:ARBA00012794};
DE EC=2.1.1.221 {ECO:0000256|ARBA:ARBA00012797};
DE AltName: Full=Mitochondrial ribonuclease P protein 1 {ECO:0000256|ARBA:ARBA00030623};
DE AltName: Full=RNA (guanine-9-)-methyltransferase domain-containing protein 1 {ECO:0000256|ARBA:ARBA00029803};
DE AltName: Full=mRNA methyladenosine-N(1)-methyltransferase {ECO:0000256|ARBA:ARBA00031759};
DE AltName: Full=tRNA (adenine(9)-N(1))-methyltransferase {ECO:0000256|ARBA:ARBA00033019};
DE AltName: Full=tRNA (guanine(9)-N(1))-methyltransferase {ECO:0000256|ARBA:ARBA00029727};
DE Flags: Fragment;
GN ORFNames=N306_09857 {ECO:0000313|EMBL:KFR14577.1};
OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC Opisthocomus.
OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR14577.1, ECO:0000313|Proteomes:UP000053605};
RN [1] {ECO:0000313|EMBL:KFR14577.1, ECO:0000313|Proteomes:UP000053605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR14577.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-
CC methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:43148, Rhea:RHEA-COMP:10363, Rhea:RHEA-COMP:10364,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; EC=2.1.1.218;
CC Evidence={ECO:0000256|ARBA:ARBA00001023};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-
CC methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:55392, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12415,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:74491;
CC Evidence={ECO:0000256|ARBA:ARBA00033688};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-
CC methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:43156, Rhea:RHEA-COMP:10367, Rhea:RHEA-COMP:10368,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.221;
CC Evidence={ECO:0000256|ARBA:ARBA00000855};
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DR EMBL; KK735517; KFR14577.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091WFU0; -.
DR STRING; 30419.A0A091WFU0; -.
DR PhylomeDB; A0A091WFU0; -.
DR Proteomes; UP000053605; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0160106; F:tRNA (adenine(9)-N1)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0052905; F:tRNA (guanosine(9)-N1)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0008033; P:tRNA processing; IEA:InterPro.
DR CDD; cd18102; Trm10_MRRP1; 1.
DR Gene3D; 3.40.1280.30; -; 1.
DR InterPro; IPR028564; MT_TRM10-typ.
DR InterPro; IPR038459; MT_TRM10-typ_sf.
DR InterPro; IPR025812; Trm10_C_MTase_dom.
DR InterPro; IPR007356; tRNA_m1G_MeTrfase_euk.
DR InterPro; IPR016009; tRNA_MeTrfase_TRMD/TRM10.
DR PANTHER; PTHR13563; TRNA (GUANINE-9-) METHYLTRANSFERASE; 1.
DR PANTHER; PTHR13563:SF5; TRNA METHYLTRANSFERASE 10 HOMOLOG C; 1.
DR Pfam; PF01746; tRNA_m1G_MT; 1.
DR PROSITE; PS51675; SAM_MT_TRM10; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 134..326
FT /note="SAM-dependent MTase TRM10-type"
FT /evidence="ECO:0000259|PROSITE:PS51675"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFR14577.1"
FT NON_TER 331
FT /evidence="ECO:0000313|EMBL:KFR14577.1"
SQ SEQUENCE 331 AA; 38766 MW; 6ECD4A73B47D4D32 CRC64;
TCNPSEKLDL DEWKKVMKSG LHEEVSETVS ERKEVSTLDA AREILEMWRL AGRSVPEQIS
EEQLKTFMEC PSKSAKKKYL KYLHLKELYK KNDKRKMDEK RERRLETQEQ VSKTDETKRN
SFVFVWANFM DRAYSWRVAQ SMIFGQPLVF DMSYEKDMSV REVANTVRQI VLSESFNRRS
ADPFHIHFCN LKDDSLYLKE FVKNYREAWG KLLITVTDQC YTEVFPKDKL IYLTADSPKV
MKTFDHDKIY IVGSMVDRSI KTGVSLAQAK RLGLETAALP LEKYLLWSSG AKNLTLDQMM
HILLTLKDTG DWKKALEFVP KRKYCGFVSK P
//
