ID A0A091WGC0_OPIHO Unreviewed; 952 AA.
AC A0A091WGC0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Solute carrier family 12 member 7 {ECO:0000313|EMBL:KFR14732.1};
DE Flags: Fragment;
GN ORFNames=N306_02976 {ECO:0000313|EMBL:KFR14732.1};
OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC Opisthocomus.
OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR14732.1, ECO:0000313|Proteomes:UP000053605};
RN [1] {ECO:0000313|EMBL:KFR14732.1, ECO:0000313|Proteomes:UP000053605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR14732.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; KK735525; KFR14732.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091WGC0; -.
DR STRING; 30419.A0A091WGC0; -.
DR Proteomes; UP000053605; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 16..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..118
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 248..508
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 522..639
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 638..737
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 883..952
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFR14732.1"
FT NON_TER 952
FT /evidence="ECO:0000313|EMBL:KFR14732.1"
SQ SEQUENCE 952 AA; 106174 MW; D4E392B049BE7C1E CRC64;
AGGSYYMISR SLGPEFGGAV GLCFYLGTTF AGAMYILGTI EILLTYISPS AAVFKAEEVG
EETEAMLNNM RVYGTCIIIL MAIVVFVGVK YVNKLALVFL ACVILSIIAI YAGVIKTAFD
PPDFRICLLG NRTLSKRSFD VCAKFTESNN GTKTTNLWRL FCDSSSLNAT CDEYFILNNV
TEVQGIPGIM SGVLTVKISQ GGFSSTDGIW SALCEDSATA DSTCVSFSSC GWEYSDIMPG
CLRKCVLSIM AGSNRSGDLK DAQKSIPTGT ILAISTTSFI FILMLTDFLF FLSPLPLRFG
EAVNGNLVVG TLAWPSPWVI VIGSFFSTCG AGLQSLTGAP RLLQAIARDG IVPFIQVFGH
GKANGEPTWA LLLTAGICEI GILIASLDSV APILSMFFLM CYMFVNLACA VQTLLRTPNW
RPRFKYYHWT LSFLGMSLCL ALMFICSWYY ALIAMLIAGC IYKYIEYRGA EKEWGDGIRG
LSLNAARYAL LRVEDGPPHT KNWRPQLLVL LNLDAEQLVK HPRLLSFTSQ LKAGKGLTIV
GSVLQGLYLD KCTETQKAEE NVKALMGVEK TKGFCQMVVS PNFRDGISYL IQSAGLGGMK
HNTVLMAWPQ SWKQTENNFS WKNFVDTVRE TTAAQQALLV AKNIDLFPTN QERFTEGNID
VWWIVHDGGM LMLLPFLLRQ HKVWRRCKMR IFTVAQMDDN SIQMKKDLQM FLYHLRLNAE
VEVVEMFEND ISAFTYEKTL MMEQRSQMLK QMQLSKNERE LFFLLLLVTF LSQIQSITDE
SRGSIRRKSY SSPQSIGQDV QALLIDDYRE EEAQLIHDRN TASHSAPAIK ASVAAAVPEK
VQMTWTKEKF VAEKHKNKDS NVSGFKDIFN MKPEWGNLNQ SNVRRMHTAV KLNGVVLNKS
QHAQLVLLNM PGPPKNRKGD ENYMEFLEVL TEGLDRVLLV RGSGREVITI YS
//
