ID A0A091WIV1_OPIHO Unreviewed; 353 AA.
AC A0A091WIV1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Vacuolar protein sorting-associated protein 37A {ECO:0000313|EMBL:KFR15469.1};
DE Flags: Fragment;
GN ORFNames=N306_00535 {ECO:0000313|EMBL:KFR15469.1};
OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC Opisthocomus.
OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR15469.1, ECO:0000313|Proteomes:UP000053605};
RN [1] {ECO:0000313|EMBL:KFR15469.1, ECO:0000313|Proteomes:UP000053605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR15469.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004633}.
CC -!- SIMILARITY: Belongs to the VPS37 family.
CC {ECO:0000256|ARBA:ARBA00007617}.
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DR EMBL; KK735703; KFR15469.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091WIV1; -.
DR STRING; 30419.A0A091WIV1; -.
DR PhylomeDB; A0A091WIV1; -.
DR Proteomes; UP000053605; Unassembled WGS sequence.
DR GO; GO:0000813; C:ESCRT I complex; IEA:UniProt.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009056; P:catabolic process; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR InterPro; IPR009851; Mod_r.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR PANTHER; PTHR13678:SF2; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A; 1.
DR Pfam; PF07200; Mod_r; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 264..353
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51314"
FT COILED 218..277
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFR15469.1"
FT NON_TER 353
FT /evidence="ECO:0000313|EMBL:KFR15469.1"
SQ SEQUENCE 353 AA; 39691 MW; A67874E5ED884B92 CRC64;
SIAEIQKDVE YRLPFTVNNL TININILLPP QFPQEKPVIS IFPPVRHHLM DKQGVYVTGP
LISNFTMHSD LGKVVQSLLD EFWKNPPVLA PSSTSFPYLF NKPAGMPPYA PQGFPFLPPY
PPKETSRTMA AVPVAESVSS SYTTDRPAAP SYSLIADLPL PVPTAEAVLQ VGQNGFTYKM
PDVPDTFPEL SELSISQLTN MNEQEEVLLE QFVTLPQLKQ VITDRDELVK SIEELAKKNL
LLEPSLEAKR QTVLDKYEQL TQMKAAFEKK MQRQHELSES CSPSALQARL KVAAHEAEEE
SDTIAEDFLE GKTEIDDFLS SFMEKRTLCH CRRAKEEKLQ QAIATHSQFH APL
//
