ID   A0A091WKI4_OPIHO        Unreviewed;       882 AA.
AC   A0A091WKI4;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Proto-oncogene DBL {ECO:0000313|EMBL:KFR16109.1};
DE   Flags: Fragment;
GN   ORFNames=N306_08647 {ECO:0000313|EMBL:KFR16109.1};
OS   Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC   Opisthocomus.
OX   NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR16109.1, ECO:0000313|Proteomes:UP000053605};
RN   [1] {ECO:0000313|EMBL:KFR16109.1, ECO:0000313|Proteomes:UP000053605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR16109.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KK735827; KFR16109.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091WKI4; -.
DR   STRING; 30419.A0A091WKI4; -.
DR   PhylomeDB; A0A091WKI4; -.
DR   Proteomes; UP000053605; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 1.20.58.60; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SMART; SM00150; SPEC; 1.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053605}.
FT   DOMAIN          63..159
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   DOMAIN          564..744
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          762..878
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFR16109.1"
FT   NON_TER         882
FT                   /evidence="ECO:0000313|EMBL:KFR16109.1"
SQ   SEQUENCE   882 AA;  102014 MW;  7EA016C4A64B08A9 CRC64;
     PICAKDISDD LMKEFAFLSG GRGKDKAWII TLPDNARFNE VPEEVVSKVL TYLTSVPSQH
     ESDTKFILIL DRRLDTWTSV KMTLQKIAAS FPGNLHLVMV LRPTGFFQRT FTDIGFRFSQ
     EDFLLKLPVV MLSSVSDLLT YIDEQQLTPE FGGTLEYCHS EWVVFRTAIE SFALTVKEIA
     QMLQSFGTEL AETELPDDVY SIERILALRT EKYYQLKEDI TAVTKEGNLL LSSFEEPDSG
     ECSQDQHRER PGDWETVNRL LGQLREMETA FDGFWEKHQL KMEQYLQLLK FEQSFQEVKN
     AIEFLMGQQA ELPDTGDSVP QVKQRLKDLG HFDGTAQDLI GKAQVVILHG HQLAANHHYA
     LNLICQQCNE LRHHSDVLSD EIKRKQTRLQ KTLDLHSRLQ QALQCCDEGA YLLANQQMDK
     CQSKEGAQKA LQDIERFLES SSAYLNYDPQ ALHYDFESVL TSELKCQIQS VHVKLENVRS
     MFENRQSCFK KLLDKQVRPV QLVAPRPENP PRSKSPLFSP KHEGVCLFLV RLRTECSRWG
     CSLARGAVAE AGADIKIIHF FFLYYSHVIN ELIETERVYV EELFTVLTGY RAEMDNPAML
     ILMPPVLRNR KDVLFGNMPE IYDFHNKIFL HSLESCLGAP ERVGFCFLDR REDFQMYEKY
     CQNKPRSESL WRQCSESTFF QVSWSKLEHK LGLDSYLLKP VQRLTKYQLL LKELLKYSTS
     CDGVQELQEA LVAMLDLLKS VNDSMHQISI TGYDGDLSEL GKVLMQGSFS VWTGHRKGPT
     KMKDLARFKP MQRHLFLYEK ALVFCKKREE HGDGYDKTSS YSFKHFLKMN AVGITENVKG
     DHRKFEIWYS GREEVYVVQA QTVDLKMAWL NEIRKILFKQ QE
//