ID   A0A091WRT1_OPIHO        Unreviewed;       886 AA.
AC   A0A091WRT1;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   22-FEB-2023, entry version 26.
DE   SubName: Full=Cullin-4B {ECO:0000313|EMBL:KFR04226.1};
GN   ORFNames=N306_07067 {ECO:0000313|EMBL:KFR04226.1};
OS   Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC   Opisthocomus.
OX   NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR04226.1, ECO:0000313|Proteomes:UP000053605};
RN   [1] {ECO:0000313|EMBL:KFR04226.1, ECO:0000313|Proteomes:UP000053605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR04226.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; KK734124; KFR04226.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091WRT1; -.
DR   STRING; 30419.A0A091WRT1; -.
DR   PhylomeDB; A0A091WRT1; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000053605; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF66; CULLIN-4B; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          531..759
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          1..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          110..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   886 AA;  101709 MW;  F7B18A43FD1C52C7 CRC64;
     MFPTGFSSPN PPATAQEVRP ATDGNTSSSS SCKKRKLNNS SNSNSEREEF DSLSSCASSP
     SKNTSSSSSS VITTSSCSSS GVASSNHHLQ KKLRFEDSLD FIGLDVKMAE ESSSSSSSPA
     ASSQQQHQQQ LKNKSLLISS VAVGHHANGL TKAASSTVSS FANSKPGSAK KLVIKNFKDK
     PKLPENYTDE TWQKLKEAVE AIQNSTSIKY NLEELYQAVE NLCSYKISAN LYKQLRQICE
     DHIKAQIHQF REYPFVLFLK KIDKCWQDHC RQMIMIRSIF LFLDRTYVLQ NSMLPSIWDM
     GLELFRTHII SDQKVQNKTI DGILLLIERE RNGEAIDRSL LRSLLSMLSD LQIYQDSFEH
     RFLEETNRLY AAEGQRLMQE REVPEYLHHV NKRLEEEADR IITYLDQSTQ KPLIATVEKQ
     LLGEHLTAIL QKGLNHLLDE NRIQDLSLLY QLFSRVRGGV QVLLQHWIEY IKAFGSTIVI
     NPEKDKTMVQ ELLDFKDKVD HIIDVCFLKN EKFVNAMKEA FETFINKRPN KPAELIAKYV
     DSKLRAGNKE ATDEELEKML DKIMIIFRFI YGKDVFEAFY KKDLAKRLLV GKSASVDAEK
     SMLSKLKHEC GAAFTSKLEG MFKDMELSKD IMIQFKQYMQ NQNVPGNIEL TVNILTMGYW
     PTYVPMEVHL PPEMVKLQEI FKTFYLGKHS GRKLQWQSTL GHCVLKAEFK EGKKELQVSL
     FQTLVLLMFN EGEEFSLEEI KQATGIEDGE LRRTLQSLAC GKARVLTKSP KGKDVEDGDK
     FTCNDDFRHK LFRIKINQIQ MKETVEEQAS TTERVFQDRQ YQIDAAIVRI MKMRKTLSHN
     LLVSEVYNQL KFPVKPADLK KRIESLIDRD YMERDKENPN QYNYIA
//