ID A0A091WU49_NIPNI Unreviewed; 4608 AA.
AC A0A091WU49;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Dynein heavy chain 5, axonemal {ECO:0000313|EMBL:KFR04946.1};
DE Flags: Fragment;
GN ORFNames=Y956_16468 {ECO:0000313|EMBL:KFR04946.1};
OS Nipponia nippon (Crested ibis) (Ibis nippon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC Nipponia.
OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFR04946.1, ECO:0000313|Proteomes:UP000053283};
RN [1] {ECO:0000313|EMBL:KFR04946.1, ECO:0000313|Proteomes:UP000053283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFR04946.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KL411255; KFR04946.1; -; Genomic_DNA.
DR STRING; 128390.A0A091WU49; -.
DR eggNOG; KOG3595; Eukaryota.
DR Proteomes; UP000053283; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053283};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1959..2095
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2240..2411
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2567..2715
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 880..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3166..3228
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3414..3469
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 880..904
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFR04946.1"
FT NON_TER 4608
FT /evidence="ECO:0000313|EMBL:KFR04946.1"
SQ SEQUENCE 4608 AA; 529594 MW; AA11DDD948150EA7 CRC64;
QQKLKEEREA KRARLDGRHD YLLDAVASCV NLDKAEVEDA ILDGNQIERI DKFLAPGGLR
HLMFYYQDVE ATDTEPFGLP GTGINSHLTK KKPKVFVTEG KEVALTGVCI FFIKSSIFKP
ITTENIYQEV NFNMMNVGRD GLLKSVEQLI SEIFIPALQI MDRGWCELGE PQQASNIKQD
FLGSLEMFVS VLSGTQQSLL EKVNLKKCET YDLKTLRGPS DYLMAANSIG GLERIEVCMK
VWTKQIEQVL AENDQLRKEA DDLGPRAELD YWKKRLSKFN YLTDQLKSPD VKAVLGVLTA
AKSKLLKNWR TLDIRITDAA NEAKDNVKYL YSLEKCCDPL YNSDPVSMVD AIPALINAIK
MIQSISQYYN TSEKISSLFV KVTNQMITAC KSYITNNNTA TIWTQPQERV MEKLQAAIRL
KQEYQNCFHK IKEKLEQNPD GRQFDFSEIY IFGKFETFHR RLVKIMDIFN TMKAYSVLQE
SKIEGLEGMI TKYESIVDTM KKRHYNFLDQ RRTDFDQDYE EFCREINDLH DQLRIFMDIT
FENILNTERA LSMLKKFERL PIPNLGIDEK YQKILRNYGH DIETVCKIYT RQKQDPPLAR
NLPPIAGKIL WARHLFHKIQ EPMESFQRHP AVLRTPDGKR IIRNYNKVAK VLMEFEVIYH
RGWLQQIELT KRRLQAPLLV KAPETGELFV NFDPQILTLI RETDCIAHMC LEIPPFASIV
QQKRDWYKKI VNNLQVMLSE YKRIKLKIQH PIEQLMAPRL ANVDDAIQPG LMLLTWTSFN
IEKYINTVFY KLAGLELLLD RVNDLIEFRI DAVLQEMNRV LLCKLPEDEP LSCEEFLQKT
KELCIKGSRT LHLKSSLVED AANELINMLL DTEIQVRKED KSVEPTTEIR GKNTATEEER
RSKSLTSSPN SSEIWAELSS PAKRKRTDLE MLEEEANELL SYFNHCNIDA LLKVTRNTLE
TIRKRIHASS MINFLENHNA SKQKKSAHPI IRTSINLSIP NIIMTPSLDE VQQTLNKAVD
NIVKVMKGVG QWSMERISKK TVLERKVAVL RCESRDSDSD DGMRETGKKN IHDAASLSLS
DPVQSQNYFK SVSENKEIIK LVSLLSTAIN STKREVLTAL ESFSCYHHIW QRDKEETIDK
LMMVNPLLSE FESEILHFQD LELKINSEPE YICVGAIALY TADLKLALRV EAKAWMTLLG
CHCNKKYRTE MEAIFTFIEE TGKKLNRHIK DLDDIRTAMS ALKEIRELQI SIDSQIGPIE
ESYAMLNKYD LLVAKEETEK VDTLHYTWEK LLVRANEVQN ELIALQPNFR GELISAVKTF
TEDCAQFYSD YDQASNGPMV VGLEPQEASD RLTMFQNRFD NLFRKYITYT SGEDLFGLPV
TRYPQLLEIK KQLNLLQKLY NLYNNVIDTV SGYYDILWSE KDIGKINGEL LEFQNRCRNL
PRGVKEWQAF FDLKKTIEDF SECCPLLERM SSKAMMPRHW KRITDLTEHN FDVESETFKL
RNIMEAPLLR YKEEIEDICI SAVKERDIEQ KLKQVIAEWD NKTFIFANFK TRGELLLRGD
STSETIATME DSLMILGSLM SNRYNTPFKT QIQKWVHYLS NTTDIIENWM TVQNLWIYLE
AVFVGGDIAK QLPKEAKRFS NIDKSWVKIM TRAHETPNVV QCCIGDEIMG QLLPHLLEQL
EICQKSLTGY LEKKRLLFPR FFFVSDPALL EILGQASDSH NIQAHLLNVF DNIKTVRFHE
RIYDRILSIS SREGETVELA RPVMAEGNVE VWLNSLLKES QLSLHHVIRQ AAAHIQETSF
QLTEFLSTYP AQVGLLGIQM IWTRDSEEAL TNARYDKKIM RKTNQFFLDL LNMLIDMTTK
DLSPVERVKY ETLITIHVHQ RDIFDGLCCM HVKSPTDFEW LKQCRFYFNE DSDKMMIKIT
DVGFTYQNEF LGCTDRLVIT PLTDRCYITL AQALGMNMGG APVGPAGTGK TETIKDMGRC
LGKYVVVFNC SDQMDFRGLG RIFKGLAQSG SWGCFDEFNR IDLPVLSVAA QQIAIVLTCK
KERKKSFIFT DGDNVEMNPE FGIFLTMNPG YAGRQELPEN LKINFRSVAM MVPDRQIIIR
VKLASCGFIA NVLLARKFFT LYKLCEEQLS KQVHYDFGLR NILSVLRTLG AAKRANPTDT
ESTIVMRVLR DMNLSKLIDE DEPLFLSLIE DLFPDIQLDK VGYPELEAAI DKRVEEAGLV
CHPPWKLKVI QLFETQKVRH GLMTLGPSGA GKTVCIHTLM KAMTDCGQPH REMRMNPKAI
TAPQMFGRLD VATNDWTDGI FSTLWRKTLR AKKGDHIWIV LDGPVDAIWI ENLNSVLDDN
RTLTLANGDR IPMAPNCKIV FEPHNIDNAS PATVSRNGMV FMSSSVLNWS PILEGFLKRR
SFQEAEILRQ LYSSSFPDLY RFSIQSLQCK TEMLEAFVIM QSINMLQGLI PTKEQGGEFT
PKYLERLYVF SLMWSIGALL EVEDRCKMEH WLRNHATIKL DLPCIPEGSE DTMFDYYVAS
DGKWMHWNTR VEEYVYPSSS TPEYGSILVP NVDNVRMDFL IETVAKQGKA VLLIGEQGTA
KTVIIKRFMS KYNPESHMAK SLNFSSATTP LIFQRTIESY VDKRMGTTYG PPAGKKMTVF
IDDVNMPIIN EWGDQVTNEI VRQLMEQNGL YNLEKPGEFT NIVDIQFLAA MIHPGGGRND
IPQRLKRQFS VFNCTLPSNS SIDKIFGVIG EGHYCSERGF SEDVKKTVAK LVPLTRRLWQ
VTKLKMLPTP AKFHYIFNLR DLSRIWQGML NTTSEVINEP KVLIKLWKHE CKCVIADRFT
TSEDVNWFDT AVAKLIEEEF EETKALLDPE IDAFFVDFLR DAPERTGEKS EEVNLDIPKI
YEPIYSFHRL RNCLNMFLKT YNENVRGIGM DMVFFEDAMI HLVKISRVIR TPRGNALLVG
VGGSGKQSLT RLASFIAGYD TFQIMLTRSY NTLNLMEDLK LLYRTAGLQG KGICFLFTDN
EIKDESFLEY LNNVLSSGEV SNLFARDEVD EIISDLIPTF KKEHPRRPPT SEVLYDYFMT
RVHQNLHVVL CFSPVGEKFR NRALKFPALI SGCTIDWFSR WPKDALVAVS EHFLSSFDMD
CTADTKREIV QCMGSFQDGV AEKCSDYFQR YRRSTHVTPK SYLSFIQGYK TTYKEKRAEV
QTLANRMNTG LEKLKEASES VAALSRELEV KEKELQIANE KADMVLKEVT VKAQAAEKVK
GEVQKVKDKA QAIVDSISVD KAIAEEKLEA AKPALEEAEA ALQTIKPADI ATVRTLGRPP
HLIMRIMDCV LLLFQRKVNN VKIDQEKCCT IPSWQESLKL MTAGNFLQNL QQFPKDTINE
EVVELLSPYF EMVDYNIETA KRVCGNVAGL CSWTKAMAVF FSINKEVLPL KANLAIQENR
LTTAMLDLQK AQEELGAKQE ELDIVQAEYE KAMREKQTLL EDAERCRHKM QTASSLISGL
AGEKERWTEQ SKEFAVQTKR LVGDVLLATA FLSYSGPFNQ EFRSLLLNDW QKEMKSRKIP
FSNNLNLIEM LTDAPTISEW NLQGLPSDDL SIQNGIIVTK ASRYPLLIDP QAQGKIWIKN
KEDRNELQIT SLNHKYFRNH LEDSLSLGRP LLIEDVGEEL DPALDNVLER NFIKTGSANK
VKVGDKEVDV MNGFRLYITT KLPNPCYSPE ISAQTSIIDF TVTMKGLENQ LLGRVILTEK
QELEKERTDL IEDVTMNKRR IKDLEDNLLF RLTSTKGSLA DDESLIIVLS NTKKTAEEVT
QKLQTSAETE VQINSAREEY RPVATRGSIL YFLITEMSMV NVMYQTSLRQ FLGLFDRSLA
RSTKSPITSK RITNIIEHMT YEVFKYAARG LYEEHKFLFT LLLTLKIDIQ RNRVKHEEFL
TLIKGGASLD LKACPPKPAK WILDMTWLNL VELSKLKQFS DILDQISRAE KQWKIWFDSE
NPEEELVPSG YGQSLDCFRH LLLIRSWCPD RTIAQARKYI IDTMGEKYAE GVILDLEKTW
EESDPRTPLI CFLSMGSDPT DSIIALGKRL KTETRYVSMG QGQEIHARKL LQQTMARGGW
ALLQNCHLGL DFLDELMDTV IETEIVHESF RLWMTTEIHK QFPITLLQMS IKFTNEPPQG
LRAGLKRTYS GVSQDLLDVS DMVQWKPMLY AVAFLHSTVQ ERRKFGSLGW NIPYEFNQAD
FNATVQFIQN HLDGMDAKRG VSWSTVCYMI GEIQYGGRVT DDYDKRLMNT FVKVWFSENT
FSQDFSFYKG YSIPKCTMVE QYLQYIQSLP AYDTPEVFGL HPNADITYQS KLSKDILDII
LSIQPKDSSG GGGETREAVV ARLAGDMLEN LPADYVPFEV KEKLKNMGPF QPMNIFLRQE
IEQMQRVISL VRSTLTDLKL AIDGTIVMSE NLRDALDCMY DGRIPASWKK ASWASSTLGF
WFTELLERNH QFYNWIFESR PNCFWMTGFF NPQGFLTAMR QEITRANKGW ALDSVVLCNE
VTKWMKDDIT SPPLEGVYVY GLYLEGAGWD RRNMRLTESK PKVLFEMMPV IRIYAENNTS
KDPRLYSCPV YKKTIRTDMN YIAAVDLKTL QPPEHWVLRG VALLCDVK
//
