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Database: UniProt
Entry: A0A091X028_NIPNI
LinkDB: A0A091X028_NIPNI
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ID   A0A091X028_NIPNI        Unreviewed;      1004 AA.
AC   A0A091X028;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   10-APR-2019, entry version 26.
DE   RecName: Full=Trifunctional purine biosynthetic protein adenosine-3 {ECO:0000256|RuleBase:RU363089};
DE   Includes:
DE     RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|RuleBase:RU363089};
DE              EC=6.3.4.13 {ECO:0000256|RuleBase:RU363089};
DE     AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|RuleBase:RU363089};
DE              Short=GARS {ECO:0000256|RuleBase:RU363089};
DE     AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|RuleBase:RU363089};
DE   Includes:
DE     RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase {ECO:0000256|RuleBase:RU363089};
DE              EC=6.3.3.1 {ECO:0000256|RuleBase:RU363089};
DE     AltName: Full=AIR synthase {ECO:0000256|RuleBase:RU363089};
DE              Short=AIRS {ECO:0000256|RuleBase:RU363089};
DE     AltName: Full=Phosphoribosyl-aminoimidazole synthetase {ECO:0000256|RuleBase:RU363089};
DE   Includes:
DE     RecName: Full=Phosphoribosylglycinamide formyltransferase {ECO:0000256|RuleBase:RU363089};
DE              EC=2.1.2.2 {ECO:0000256|RuleBase:RU363089};
DE     AltName: Full=5'-phosphoribosylglycinamide transformylase {ECO:0000256|RuleBase:RU363089};
DE     AltName: Full=GAR transformylase {ECO:0000256|RuleBase:RU363089};
DE              Short=GART {ECO:0000256|RuleBase:RU363089};
DE   Flags: Fragment;
GN   ORFNames=Y956_04387 {ECO:0000313|EMBL:KFR06926.1};
OS   Nipponia nippon (Crested ibis) (Ibis nippon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae;
OC   Nipponia.
OX   NCBI_TaxID=128390 {ECO:0000313|EMBL:KFR06926.1, ECO:0000313|Proteomes:UP000053283};
RN   [1] {ECO:0000313|EMBL:KFR06926.1, ECO:0000313|Proteomes:UP000053283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFR06926.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-D-
CC         ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) +
CC         N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide;
CC         Xref=Rhea:RHEA:15053, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453,
CC         ChEBI:CHEBI:57454, ChEBI:CHEBI:58426, ChEBI:CHEBI:58457;
CC         EC=2.1.2.2; Evidence={ECO:0000256|RuleBase:RU363089};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP
CC         = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) +
CC         phosphate; Xref=Rhea:RHEA:23032, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58478,
CC         ChEBI:CHEBI:137981, ChEBI:CHEBI:456216; EC=6.3.3.1;
CC         Evidence={ECO:0000256|RuleBase:RU363089};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|RuleBase:RU363089};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC       phospho-D-ribosyl)glycinamide: step 2/2.
CC       {ECO:0000256|RuleBase:RU363089}.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|RuleBase:RU363089}.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-
CC       phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.
CC       {ECO:0000256|RuleBase:RU363089}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the GART family.
CC       {ECO:0000256|RuleBase:RU363089}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the GARS family.
CC       {ECO:0000256|RuleBase:RU363089}.
CC   -!- SIMILARITY: In the central section; belongs to the AIR synthase
CC       family. {ECO:0000256|RuleBase:RU363089}.
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DR   EMBL; KL411408; KFR06926.1; -; Genomic_DNA.
DR   STRING; 128390.XP_009471776.1; -.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000053283; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004644; F:phosphoribosylglycinamide formyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd08645; FMT_core_GART; 1.
DR   CDD; cd02196; PurM; 1.
DR   Gene3D; 3.30.1330.10; -; 1.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   Gene3D; 3.90.650.10; -; 1.
DR   HAMAP; MF_00741; AIRS; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   HAMAP; MF_01930; PurN; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR002376; Formyl_transf_N.
DR   InterPro; IPR036477; Formyl_transf_N_sf.
DR   InterPro; IPR004607; GART.
DR   InterPro; IPR001555; GART_AS.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR010918; PurM-like_C_dom.
DR   InterPro; IPR036676; PurM-like_C_sf.
DR   InterPro; IPR016188; PurM-like_N.
DR   InterPro; IPR036921; PurM-like_N_sf.
DR   InterPro; IPR004733; PurM_cligase.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   PANTHER; PTHR10520; PTHR10520; 1.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   Pfam; PF00551; Formyl_trans_N; 1.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   SUPFAM; SSF53328; SSF53328; 1.
DR   SUPFAM; SSF55326; SSF55326; 1.
DR   SUPFAM; SSF56042; SSF56042; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   TIGRFAMs; TIGR00878; purM; 1.
DR   TIGRFAMs; TIGR00639; PurN; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
DR   PROSITE; PS00373; GART; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
KW   ECO:0000256|RuleBase:RU363089};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053283};
KW   Ligase {ECO:0000256|RuleBase:RU363089};
KW   Manganese {ECO:0000256|RuleBase:RU363089};
KW   Metal-binding {ECO:0000256|RuleBase:RU363089};
KW   Multifunctional enzyme {ECO:0000256|RuleBase:RU363089};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
KW   ECO:0000256|RuleBase:RU363089};
KW   Purine biosynthesis {ECO:0000256|RuleBase:RU363089};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053283}.
FT   DOMAIN      113    320       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFR06926.1}.
FT   NON_TER    1004   1004       {ECO:0000313|EMBL:KFR06926.1}.
SQ   SEQUENCE   1004 AA;  107041 MW;  8DAA2A248DE8ADC9 CRC64;
     RLMADRVLVI GSGGREHALA WKLAQSPHVK HVFVAPGNAG TADNGKISNS AVSVSNHAAL
     AQFCRDQEIR LVVVGPEVPL AAGIVDDLTA AGVRCFGPTA KAAQLESSKS FTKAFLDRHE
     IPTARWKSFT DPKAACSFIN SANFPALVVK ASGLAAGKGV IVASNKEEAC KAVTEIMQDK
     TFGTAGETVV VEELLEGEEV SCLCFTDGVT IAPMPPAQDH KRLMDGDEGP NTGGMGAYSP
     APQISKQLLQ KIRDTVLQKT VDGMRKEGVP YFGVLYAGLM LTNDGPKVLE FNCRFGDPEC
     QVILPLLKSD LYEVMQAVIN KKLSSSMPVW FEDSAAVTVV MASEGYPGTY PKGLEITGLS
     KAKQLGLEVF HAGTSLKDGK VVTSGGRVLT VTAIKEDLMT ALQEANKGVA AIHFKGAVYR
     RDIGYRAIAF LRQSRGLTYK NSGVDIAAGN TLVQKIKPLA AATSRSGCNA ELGGFAGLFD
     LKAAGYEDPI LVSGTDGVGT KLKIAQVCKR HDTIGQDLVA MCVNDILAQG AEPLFFLDYF
     ACGKLDVEVA RGVISGIAEA CKKAGCALLG GETAEMPGMY PPGEYDLAGF AVGAVERGQM
     LPQLERIADG DVVIGVASSG VHSNGYSLVR KIVEKSSFDF SSPVGISGDQ TLGDLLLTPT
     KIYSKTLLPI LRSGHVKAYA HITGGGLLEN IPRVLPESFG VVLDALTWKI PEIFCWLHKE
     GNLSEEEMAR TFNCGIGAVL VVQKELAQQV LKDVQRHEAA WLIGKVVSLQ KGSARVKIHN
     MLRALQANRS LSVHSHIQGK IQANKVKVAV LISGTGTNLE ALINSTKKPT SFAQIVLVVS
     NKAGVEGLRK AERAGIPTRV IDHKLYESRT EFDSAVDKVL EEFSVELICL AGFMRILSGP
     FVKKWEGKIL NIHPSLLPSF KGANAHKLVL QAGVRVTGCT VHFVAEEVDA GGIIFQEAVP
     VKIGDTVETL SERVKEAEHR AFPAALQLVA SGAVQVGEAG KIYW
//
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