ID A0A091XGZ6_OPIHO Unreviewed; 1181 AA.
AC A0A091XGZ6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Tyrosine-protein phosphatase non-receptor type {ECO:0000256|PIRNR:PIRNR000934};
DE EC=3.1.3.48 {ECO:0000256|PIRNR:PIRNR000934};
GN ORFNames=N306_04552 {ECO:0000313|EMBL:KFR12481.1};
OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC Opisthocomus.
OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR12481.1, ECO:0000313|Proteomes:UP000053605};
RN [1] {ECO:0000313|EMBL:KFR12481.1, ECO:0000313|Proteomes:UP000053605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR12481.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|PIRNR:PIRNR000934};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR000934}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649,
CC ECO:0000256|PIRNR:PIRNR000934}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK735116; KFR12481.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091XGZ6; -.
DR STRING; 30419.A0A091XGZ6; -.
DR Proteomes; UP000053605; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13188; FERM_C_PTPN14_PTPN21; 1.
DR CDD; cd17192; FERM_F1_PTPN21; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR014392; PTP_non-rcpt_14/21.
DR InterPro; IPR041782; PTPN14/21_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF3; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 21; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PIRSF; PIRSF000934; Tyr-Ptase_nr14; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR000934};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR000934}; Hydrolase {ECO:0000256|PIRNR:PIRNR000934};
KW Protein phosphatase {ECO:0000256|PIRNR:PIRNR000934};
KW Receptor {ECO:0000313|EMBL:KFR12481.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053605}.
FT DOMAIN 23..304
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 903..1174
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1085..1165
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 707..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1115
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
SQ SEQUENCE 1181 AA; 135083 MW; 886B4730D828B76A CRC64;
MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE AVAQRLELRE
ITYFSLWYYN KQNQRRWVDL DKPLKKQLDK YALEPTVYFG VVFYVPAVSQ LQQYQYYLQL
KKDILEGNIP CTLEQAIHLA GLAVQADFGD YDQYESQEFL QRFALFPVAW LQEEKILEEA
TKKVALLHQK YRGLTPPDAE MLYMQEVERM EGYGEETYPA KDSQGSDIFI GACLDGIFVK
HKNGRPPVVF RWHDIANMSH NKSFFALELA NKEETIQFQT EDMETAKYVW RMCVARHKFY
RLNKCSLQTQ PITVNPVRRR SSSRMSMPKP QPYMMPPPPQ LHYNGHYTEP YASSQDNLFV
SNQNGYYCHS QTSLDRAPHD YSGRIRNGSV YSAHSTNSLN NPQHYLQPSP MSSNPSITGS
DVLRTDYIPS HRHSALIPPS YRPTPDYETV MRQLNRGMMQ TDRQSHSMRN LNISNSYAYS
RPDALVYSQP EIREHAHFAS PQSNHYPFNL NYSFHSQSPY PYPAEKRPVV GAVCVPELTN
VQLQAQDYPA PNIMKTQVYR PPPPYPYPRP ANSTPDLSRH IYISSSNPDL ITRRVHHSVQ
TFQEDSLPVA HSLQEVSEPL TSARHAHLQK RNSIEIAGLT PSFEGIRIKE RTMSASAADV
ALPRVISEGS QPNILMERTK HKENKQEEGV NCDHKKTLSD ATMLIHSSEE EEEFEEENKA
GTSLSPLPED QTKLSSLMGG YSCDSVLNYP HSSVASSAGP LHILEPKLHI TETEKRMKDK
SPIQLLVESQ VQRRGEGLLT PSMSESDLTT SGRYRVRKDS VKKRPVSDLL SGKKNIVEGL
PPLGGMKKNK NDAKKIGPLK LAALNGLALT RMPLPDEGKE ESTRATNDER CKVLEQRLEQ
GMVFTEYERI QKKRLIDGEC SIARLPENAE RNRFQDVLPY DDTRVELVPT KENNTGYINA
SHIKITVGGI EWDYIATQGP LQNTCQDFWQ MIWEQGIAII AMVTAEEESG REKSFRYWPR
LGSRHNTVTY GRFKITTRFR TDSGCYATTG LKIKHLLTGQ ERTVWHLQYT DWPEHGCPED
LKGFLSYLEE IQSVRRHTNS TVDPKNSNPP VLVHCSAGVG RTGVVILSEV MIACLEHNEM
LDIQRVLDML RQQRMMMVQT LSQYTFVYGV LIQFLKSSRL I
//
