ID A0A091XN26_OPIHO Unreviewed; 3611 AA.
AC A0A091XN26;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE Flags: Fragment;
GN ORFNames=N306_07250 {ECO:0000313|EMBL:KFR14416.1};
OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC Opisthocomus.
OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR14416.1, ECO:0000313|Proteomes:UP000053605};
RN [1] {ECO:0000313|EMBL:KFR14416.1, ECO:0000313|Proteomes:UP000053605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR14416.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; KK735490; KFR14416.1; -; Genomic_DNA.
DR STRING; 30419.A0A091XN26; -.
DR PhylomeDB; A0A091XN26; -.
DR Proteomes; UP000053605; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05170; PIKKc_SMG1; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR031559; SMG1.
DR InterPro; IPR035175; SMG1_N.
DR InterPro; IPR039414; SMG1_PIKKc.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF71; SERINE/THREONINE-PROTEIN KINASE SMG1; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF15785; SMG1; 2.
DR Pfam; PF17229; SMG1_N; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFR14416.1};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1233..1816
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2074..2413
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3579..3611
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1847..1866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3519..3553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1924..1951
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3519..3533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFR14416.1"
FT NON_TER 3611
FT /evidence="ECO:0000313|EMBL:KFR14416.1"
SQ SEQUENCE 3611 AA; 404570 MW; 9775AF41AE8B5FBE CRC64;
RTDSASADQD NLKYSSSRDR GSSASYGLQP SNSAVVSRQR HDDIRVHTDI QNEEKGGYSV
NGGSGENTYG RKSLGQELRV NNVTNPDFTS VPHGNRALAT KDMRKSQERS LSYSDESRLS
NLLRRITRED DRDRRLATVK QLKEFIQQPE NKLVLVKQLD NILTAIHDVL NESSKLLQEL
RQEGACCLGL LCASLSYEAE KIFKWIFSKF SSSTKDEVKL LYLCATYKAL ETVGEKKAFS
SLMQLVMTSL QSILENVDTP ELLCKCVKCI LLVSRCYPHI FSTNFRDTVD ILVGWHIDHT
QKPSLTQQVS GWLQSLEPFW VADLTFSTTL LGQFLEDMEA YAEDLSHVAS GESVDEDIPP
PSVSLPKLAA LLRVFSTVVR SIGERFSPIR GPPITEAYVT DVLYRVMRCV TAANQVFFSE
AVLTAANECV GVLLGSLDPS MTIHCDMVIT YGLDQMENCQ TCGTDYIISV LNLLTLVVEQ
INTKLPSSFV EKLFIPESKL LVLRYHKEKE VVAAAHAVYQ AVLSLKNIPV LETAYRLILG
EMTCALNSLL YSLHLPDACS EIQHDSFKKR IFNVDNAMFV VIFDLSALST IGNAKNSLIG
MWALSPTVFA LLSKNLMIVH GDIAVHFPAV QYAVLYTLYS HCSRHDHFIS SSLSSSSPSL
FDGAVISTVT TATKKHFSII LNLLGLLLKK DNLTQDTRRL LITWALEVAV LMKKSETYGP
LFSLPSFHKF CKGLLANTLL EDTNICLQAC SSLHALSSSL PDDLLQRCVD VCRVQLVHSG
ARVRQTFGKL LKSIPLDVVL SNRTHTEIQE ISLAIRSHMS KAPSNTFHPQ DFSDVISFIL
YGNSHRTGIP RNLLKTDAVL WQWAVWEAAQ FTVLSKLRTP LGRAQDTFQT IEGIIRSLAA
HTLNPDQDVS QWTTADNDEG HSSNQLRLVL LLQYLENLEK LMYNAYEGCA NALTSPPKVC
LTFFYTNRQT CQDWLTRIRL SIMRVGLLAG QPAVTVRHGF DLLTEMKTNN SISQGNELEV
TIMMLVEALC ELHCPEAIQG IAVWSSAVVG KSLAWINSVA QQAEGRFEKA AVEYQEHLCS
MTGADCCITG FDKTVLKLAN SNSVNNASPK HSLNGEARKT VLTKPSDSSP EVINYLGNKA
CECYISIADW SAVQEWQNMV HDLKKSNSNT SINLKADFNY IKSLSSFESG QLTECTEQLE
LLPGENINLL AGGSKEKIDM KKLLPNMLSP DPRELQKAVE VQLLRSSVCL ATAVNHIEQE
QKWQSISENV VKYLKQTSRI AIGPLRLSTL TVSQSLPVLS TLQLYCSSAL ENTVSNRLTS
EDCLIPLFND ALRSCKQHDV RPWMHALRYT VYQNQLMEKL KEPTVPIKSH LMELGLTAAK
FARKRGNIAL ATRLLAQCSE VQLGKTTTAQ DLVQHFKKLS APGQIDEKWG PELDIEKTKL
LYTAGQSTHA MEMLSSCAIS FCKSAKAEYA VAKSILTLAK WIQAEWKEIS GQLKQVYRAR
QQQNHTGLST LSKNIYNLID LPAVNTLEEE YPRIESESTV NIGVGEPDFI LGQLYHLSSV
QAPEVAKSWA ALASWAYRWG RKVVDNASQG EGVRLLPREK SEVQNLLPDN IAEEDREKIY
GILGQAVCRP AGIQDEDMTL QITENEDNEE DDMVDVIWRQ LLTSCPWLSD LDENATEGLI
KVWRKVVDRI FSLYKLSCSA YFTFLKLNAG QVPLDEDDPR LHLRNTSEQS TDDVIVMATL
RLLRLLVKHA GELRQYLEHG LETTPTAPWR GIIPQLFSRL NHPEVYVRQS ICNLLCRVAQ
DSPHLILYPA IVGTISLSSE SQSSGNKLPS AIPTLLGNIQ GEELLGGECD GGSPPASQDS
SKDDTKVGLN EDQAMMQDCY SKIVEKLSAA NPTMVLQVQM LVAELRRVTV LWDELWLGVL
LQQHMYVLRR IQQLEDEVKR VQNNNTLRKE EKIAIMREKH TALMKPIVFA LEHVRSITAA
PAETPHEKWF QDNYGDAIEN ALEKLKNPLN PAKPGSSWLP FKEVMLSLQQ RAQKRASYLL
RLEEISPWLA AMMNTEIALP GEVSTRDTVT IHSVGSTITI LPTKTKPKKL LFLGSDGKNY
PYLFKGLEDL HLDERIMQFL SIVNTMFATI NRQETPRFHA RHYSVTPLGT RSGLIQWVDG
ATPLFGLYKR WQQREAALQA QKAQDSYQTP QNPGIVPRPS ELYYSKIGPA LKAVGLSLDV
SRRDWPLNVM RAVLEELMEA TPPNLLAKEL WSSCTTPDEW WRVTQSYARS TAVMSMVGYI
IGLGDRHLDN VLIDMTTGEV VHIDYNVCFE KGKSLRVPEK VPFRMTHNIE TALGVTGVEG
VFRLSCEQVL HIMRRGRETL LTLLEAFVYD PLVDWTAGGE AGFAGAVYGG GGQQAENKQS
KREMERDITR SLFSSRVAEI KVNWFKNRDE MLAVLPKLDS SLEEYLNLQE QLTDVEKLQG
KLLEEIEFLE GAEGVDHPSH TLQHRYSEHT QLQSQQRAVQ EAIQVKLNEF EQWITHYQTA
FSNLEATQLA SLLQEISTQM DLGPPSYVPA TAFLQNAGQA HLISQCEQLE GEVGALLQQR
RSVLRGCLEQ LHNYATVALQ YPKAVFQKHR IEQWKTWMEE LICNMTIERC QDIFRKYEMQ
YAPQPPPSMC QFITTTEMTL QRYAADINNR LIRQVERLKQ EAVTVPVCEE QLKEIERCIK
VFLHENGEEG SLSLASVIIS ALCTLTRRNL MMEGAASSAG EQLVDLTSRD GAWFLEELCS
MSGNVTCLVQ LLKQCHLVPQ DLDIPNPIEA SEAVHLANGV YISLQELNSN FRQIIFPEAL
RCLMKGEYTL ESMLHELDNL IEQTTDGVPL QTLVESLQAY LGNAAMGLEE ETHTHYIDVA
RVPHAQYGEL IQPRNGSVDE TPKMSAGQML LVAFDGMFAQ VETAFGLLIE KLNKMEIPVA
WRKIDIIREA RSTQVNFFDD DNNRQVLDEI FFLKRLQTIK EFFRLCGTFS KTLSGISSLE
DQNAVNGPVQ IVNVKTLYRN SCFSEDQMAK PIKAFTADFV RQLLIGLPNQ ALGLTLCSFI
SALGVDIIAQ VEAKDFGAES KVSVDDLCKK AVEHNIQIGK FSQLVMNRAT VLASSYDTAW
KKHDLVRRLE TSISSCKTSL QRVQLHIAMF QWQHEDLLIS RPQAISVTPP PRSAILASMK
KKLHTLSQIE ASIATVQEKL AALEASIEQR LKWAGGANPA LAPVLQDFDA TIAERRNLVL
KESQRASQVT FLCSNIIHFE SLRTRTAEAL NLDAALFELL KRCQQMCSFA SQFNSSVSEL
ELRLLQRVGT GLEHPIGSSE WLHSAHKQLT QEISTQRTVQ TEREQQIETV CETIQNLVDS
IKTVLTGHNR QLGDVKHLLK AMAKDEEAAL ADGEEVPYES SVRQFLGEYK SWQDNIQTVL
FTLVQVMGQV RSQEHVEMLQ EITPTLKELK TQSQSVYNNL VGFASPLVTD TSNECSSPTS
AATYQPTFAA AVRSNTGQKT QPEVMSQNAR KLIQKNLATS ADTPPSTVPG TGKSVACSPK
KTARDPKTGK AVQERNSYAV SVWKRVKAKL EGRDVDPNRR MSVAEQVDFV IKEATNLDNL
AQLYEGWTAW V
//