GenomeNet

Database: UniProt
Entry: A0A091XN26_OPIHO
LinkDB: A0A091XN26_OPIHO
Original site: A0A091XN26_OPIHO 
ID   A0A091XN26_OPIHO        Unreviewed;      3611 AA.
AC   A0A091XN26;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE   Flags: Fragment;
GN   ORFNames=N306_07250 {ECO:0000313|EMBL:KFR14416.1};
OS   Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae;
OC   Opisthocomus.
OX   NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR14416.1, ECO:0000313|Proteomes:UP000053605};
RN   [1] {ECO:0000313|EMBL:KFR14416.1, ECO:0000313|Proteomes:UP000053605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR14416.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KK735490; KFR14416.1; -; Genomic_DNA.
DR   STRING; 30419.A0A091XN26; -.
DR   PhylomeDB; A0A091XN26; -.
DR   Proteomes; UP000053605; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05170; PIKKc_SMG1; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003152; FATC_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR014009; PIK_FAT.
DR   InterPro; IPR031559; SMG1.
DR   InterPro; IPR035175; SMG1_N.
DR   InterPro; IPR039414; SMG1_PIKKc.
DR   PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR   PANTHER; PTHR11139:SF71; SERINE/THREONINE-PROTEIN KINASE SMG1; 1.
DR   Pfam; PF02260; FATC; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF15785; SMG1; 2.
DR   Pfam; PF17229; SMG1_N; 1.
DR   SMART; SM01343; FATC; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SMART; SM01345; Rapamycin_bind; 1.
DR   SUPFAM; SSF48371; ARM repeat; 3.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51189; FAT; 1.
DR   PROSITE; PS51190; FATC; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFR14416.1};
KW   Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1233..1816
FT                   /note="FAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51189"
FT   DOMAIN          2074..2413
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
FT   DOMAIN          3579..3611
FT                   /note="FATC"
FT                   /evidence="ECO:0000259|PROSITE:PS51190"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1847..1866
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3519..3553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1924..1951
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3519..3533
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFR14416.1"
FT   NON_TER         3611
FT                   /evidence="ECO:0000313|EMBL:KFR14416.1"
SQ   SEQUENCE   3611 AA;  404570 MW;  9775AF41AE8B5FBE CRC64;
     RTDSASADQD NLKYSSSRDR GSSASYGLQP SNSAVVSRQR HDDIRVHTDI QNEEKGGYSV
     NGGSGENTYG RKSLGQELRV NNVTNPDFTS VPHGNRALAT KDMRKSQERS LSYSDESRLS
     NLLRRITRED DRDRRLATVK QLKEFIQQPE NKLVLVKQLD NILTAIHDVL NESSKLLQEL
     RQEGACCLGL LCASLSYEAE KIFKWIFSKF SSSTKDEVKL LYLCATYKAL ETVGEKKAFS
     SLMQLVMTSL QSILENVDTP ELLCKCVKCI LLVSRCYPHI FSTNFRDTVD ILVGWHIDHT
     QKPSLTQQVS GWLQSLEPFW VADLTFSTTL LGQFLEDMEA YAEDLSHVAS GESVDEDIPP
     PSVSLPKLAA LLRVFSTVVR SIGERFSPIR GPPITEAYVT DVLYRVMRCV TAANQVFFSE
     AVLTAANECV GVLLGSLDPS MTIHCDMVIT YGLDQMENCQ TCGTDYIISV LNLLTLVVEQ
     INTKLPSSFV EKLFIPESKL LVLRYHKEKE VVAAAHAVYQ AVLSLKNIPV LETAYRLILG
     EMTCALNSLL YSLHLPDACS EIQHDSFKKR IFNVDNAMFV VIFDLSALST IGNAKNSLIG
     MWALSPTVFA LLSKNLMIVH GDIAVHFPAV QYAVLYTLYS HCSRHDHFIS SSLSSSSPSL
     FDGAVISTVT TATKKHFSII LNLLGLLLKK DNLTQDTRRL LITWALEVAV LMKKSETYGP
     LFSLPSFHKF CKGLLANTLL EDTNICLQAC SSLHALSSSL PDDLLQRCVD VCRVQLVHSG
     ARVRQTFGKL LKSIPLDVVL SNRTHTEIQE ISLAIRSHMS KAPSNTFHPQ DFSDVISFIL
     YGNSHRTGIP RNLLKTDAVL WQWAVWEAAQ FTVLSKLRTP LGRAQDTFQT IEGIIRSLAA
     HTLNPDQDVS QWTTADNDEG HSSNQLRLVL LLQYLENLEK LMYNAYEGCA NALTSPPKVC
     LTFFYTNRQT CQDWLTRIRL SIMRVGLLAG QPAVTVRHGF DLLTEMKTNN SISQGNELEV
     TIMMLVEALC ELHCPEAIQG IAVWSSAVVG KSLAWINSVA QQAEGRFEKA AVEYQEHLCS
     MTGADCCITG FDKTVLKLAN SNSVNNASPK HSLNGEARKT VLTKPSDSSP EVINYLGNKA
     CECYISIADW SAVQEWQNMV HDLKKSNSNT SINLKADFNY IKSLSSFESG QLTECTEQLE
     LLPGENINLL AGGSKEKIDM KKLLPNMLSP DPRELQKAVE VQLLRSSVCL ATAVNHIEQE
     QKWQSISENV VKYLKQTSRI AIGPLRLSTL TVSQSLPVLS TLQLYCSSAL ENTVSNRLTS
     EDCLIPLFND ALRSCKQHDV RPWMHALRYT VYQNQLMEKL KEPTVPIKSH LMELGLTAAK
     FARKRGNIAL ATRLLAQCSE VQLGKTTTAQ DLVQHFKKLS APGQIDEKWG PELDIEKTKL
     LYTAGQSTHA MEMLSSCAIS FCKSAKAEYA VAKSILTLAK WIQAEWKEIS GQLKQVYRAR
     QQQNHTGLST LSKNIYNLID LPAVNTLEEE YPRIESESTV NIGVGEPDFI LGQLYHLSSV
     QAPEVAKSWA ALASWAYRWG RKVVDNASQG EGVRLLPREK SEVQNLLPDN IAEEDREKIY
     GILGQAVCRP AGIQDEDMTL QITENEDNEE DDMVDVIWRQ LLTSCPWLSD LDENATEGLI
     KVWRKVVDRI FSLYKLSCSA YFTFLKLNAG QVPLDEDDPR LHLRNTSEQS TDDVIVMATL
     RLLRLLVKHA GELRQYLEHG LETTPTAPWR GIIPQLFSRL NHPEVYVRQS ICNLLCRVAQ
     DSPHLILYPA IVGTISLSSE SQSSGNKLPS AIPTLLGNIQ GEELLGGECD GGSPPASQDS
     SKDDTKVGLN EDQAMMQDCY SKIVEKLSAA NPTMVLQVQM LVAELRRVTV LWDELWLGVL
     LQQHMYVLRR IQQLEDEVKR VQNNNTLRKE EKIAIMREKH TALMKPIVFA LEHVRSITAA
     PAETPHEKWF QDNYGDAIEN ALEKLKNPLN PAKPGSSWLP FKEVMLSLQQ RAQKRASYLL
     RLEEISPWLA AMMNTEIALP GEVSTRDTVT IHSVGSTITI LPTKTKPKKL LFLGSDGKNY
     PYLFKGLEDL HLDERIMQFL SIVNTMFATI NRQETPRFHA RHYSVTPLGT RSGLIQWVDG
     ATPLFGLYKR WQQREAALQA QKAQDSYQTP QNPGIVPRPS ELYYSKIGPA LKAVGLSLDV
     SRRDWPLNVM RAVLEELMEA TPPNLLAKEL WSSCTTPDEW WRVTQSYARS TAVMSMVGYI
     IGLGDRHLDN VLIDMTTGEV VHIDYNVCFE KGKSLRVPEK VPFRMTHNIE TALGVTGVEG
     VFRLSCEQVL HIMRRGRETL LTLLEAFVYD PLVDWTAGGE AGFAGAVYGG GGQQAENKQS
     KREMERDITR SLFSSRVAEI KVNWFKNRDE MLAVLPKLDS SLEEYLNLQE QLTDVEKLQG
     KLLEEIEFLE GAEGVDHPSH TLQHRYSEHT QLQSQQRAVQ EAIQVKLNEF EQWITHYQTA
     FSNLEATQLA SLLQEISTQM DLGPPSYVPA TAFLQNAGQA HLISQCEQLE GEVGALLQQR
     RSVLRGCLEQ LHNYATVALQ YPKAVFQKHR IEQWKTWMEE LICNMTIERC QDIFRKYEMQ
     YAPQPPPSMC QFITTTEMTL QRYAADINNR LIRQVERLKQ EAVTVPVCEE QLKEIERCIK
     VFLHENGEEG SLSLASVIIS ALCTLTRRNL MMEGAASSAG EQLVDLTSRD GAWFLEELCS
     MSGNVTCLVQ LLKQCHLVPQ DLDIPNPIEA SEAVHLANGV YISLQELNSN FRQIIFPEAL
     RCLMKGEYTL ESMLHELDNL IEQTTDGVPL QTLVESLQAY LGNAAMGLEE ETHTHYIDVA
     RVPHAQYGEL IQPRNGSVDE TPKMSAGQML LVAFDGMFAQ VETAFGLLIE KLNKMEIPVA
     WRKIDIIREA RSTQVNFFDD DNNRQVLDEI FFLKRLQTIK EFFRLCGTFS KTLSGISSLE
     DQNAVNGPVQ IVNVKTLYRN SCFSEDQMAK PIKAFTADFV RQLLIGLPNQ ALGLTLCSFI
     SALGVDIIAQ VEAKDFGAES KVSVDDLCKK AVEHNIQIGK FSQLVMNRAT VLASSYDTAW
     KKHDLVRRLE TSISSCKTSL QRVQLHIAMF QWQHEDLLIS RPQAISVTPP PRSAILASMK
     KKLHTLSQIE ASIATVQEKL AALEASIEQR LKWAGGANPA LAPVLQDFDA TIAERRNLVL
     KESQRASQVT FLCSNIIHFE SLRTRTAEAL NLDAALFELL KRCQQMCSFA SQFNSSVSEL
     ELRLLQRVGT GLEHPIGSSE WLHSAHKQLT QEISTQRTVQ TEREQQIETV CETIQNLVDS
     IKTVLTGHNR QLGDVKHLLK AMAKDEEAAL ADGEEVPYES SVRQFLGEYK SWQDNIQTVL
     FTLVQVMGQV RSQEHVEMLQ EITPTLKELK TQSQSVYNNL VGFASPLVTD TSNECSSPTS
     AATYQPTFAA AVRSNTGQKT QPEVMSQNAR KLIQKNLATS ADTPPSTVPG TGKSVACSPK
     KTARDPKTGK AVQERNSYAV SVWKRVKAKL EGRDVDPNRR MSVAEQVDFV IKEATNLDNL
     AQLYEGWTAW V
//
DBGET integrated database retrieval system