ID A0A093BEN0_CHAPE Unreviewed; 775 AA.
AC A0A093BEN0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Follistatin-related protein 4 {ECO:0000313|EMBL:KFU91030.1};
DE Flags: Fragment;
GN ORFNames=M959_14441 {ECO:0000313|EMBL:KFU91030.1};
OS Chaetura pelagica (Chimney swift) (Hirundo pelagica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Apodiformes; Apodidae;
OC Apodinae; Chaetura.
OX NCBI_TaxID=8897 {ECO:0000313|EMBL:KFU91030.1, ECO:0000313|Proteomes:UP000031515};
RN [1] {ECO:0000313|EMBL:KFU91030.1, ECO:0000313|Proteomes:UP000031515}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M959 {ECO:0000313|EMBL:KFU91030.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000031515}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=25504712; DOI=10.1126/science.1251385;
RG Avian Genome Consortium;
RA Zhang G., Li C., Li Q., Li B., Larkin D.M., Lee C., Storz J.F., Antunes A.,
RA Greenwold M.J., Meredith R.W., Odeen A., Cui J., Zhou Q., Xu L., Pan H.,
RA Wang Z., Jin L., Zhang P., Hu H., Yang W., Hu J., Xiao J., Yang Z., Liu Y.,
RA Xie Q., Yu H., Lian J., Wen P., Zhang F., Li H., Zeng Y., Xiong Z., Liu S.,
RA Zhou L., Huang Z., An N., Wang J., Zheng Q., Xiong Y., Wang G., Wang B.,
RA Wang J., Fan Y., da Fonseca R.R., Alfaro-Nunez A., Schubert M., Orlando L.,
RA Mourier T., Howard J.T., Ganapathy G., Pfenning A., Whitney O., Rivas M.V.,
RA Hara E., Smith J., Farre M., Narayan J., Slavov G., Romanov M.N.,
RA Borges R., Machado J.P., Khan I., Springer M.S., Gatesy J., Hoffmann F.G.,
RA Opazo J.C., Hastad O., Sawyer R.H., Kim H., Kim K.W., Kim H.J., Cho S.,
RA Li N., Huang Y., Bruford M.W., Zhan X., Dixon A., Bertelsen M.F.,
RA Derryberry E., Warren W., Wilson R.K., Li S., Ray D.A., Green R.E.,
RA O'Brien S.J., Griffin D., Johnson W.E., Haussler D., Ryder O.A.,
RA Willerslev E., Graves G.R., Alstrom P., Fjeldsa J., Mindell D.P.,
RA Edwards S.V., Braun E.L., Rahbek C., Burt D.W., Houde P., Zhang Y.,
RA Yang H., Wang J., Jarvis E.D., Gilbert M.T., Wang J.;
RT "Comparative genomics reveals insights into avian genome evolution and
RT adaptation.";
RL Science 346:1311-1320(2014).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; KN126585; KFU91030.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093BEN0; -.
DR Proteomes; UP000031515; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05736; IgI_2_Follistatin_like; 1.
DR CDD; cd00104; KAZAL_FS; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR10913; FOLLISTATIN-RELATED; 1.
DR PANTHER; PTHR10913:SF9; FOLLISTATIN-RELATED PROTEIN 4; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF75011; 3-carboxy-cis,cis-mucoante lactonizing enzyme; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000031515};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 28..82
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 117..152
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 192..265
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 283..368
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFU91030.1"
FT NON_TER 775
FT /evidence="ECO:0000313|EMBL:KFU91030.1"
SQ SEQUENCE 775 AA; 87555 MW; 5493DD1BB1BFDAF1 CRC64;
VLYGQDGLHA SCEKKYCGRG SKCVVNKDTN QPECRCVEDC KPSYMPVCGS DGRFYENHCQ
LHRASCLQRK KIYIIHSKDC FFKGDSCTMA DYSRLKNILL DLQAHRHSPP AQDRVSQKRL
LVEEMFQHLD GNGDGHLSAS ELAQLMKEED LEDDFLGCTL EDLLRFDDYN NDGHLTLHEL
YTAFQVVQLS LPEEQKVSLT TITVGLSTVL TCGIRGALRP PIIWKRNGVI LNFLDLEDIN
DFGEDDSLYI TKVTTIHMGN YTCHAYGYEE LYQTHILQVN VPPVIRVYPE TQAQEPGVSA
SLKCHAEGIP NPWITWLKNG LDIMPKLSKQ LVLLANGSEL HISSVRYEDT GAYTCIAKNE
VGVDEDISSL FIEDSARKTR LSVGNMFYVF SDDGITILQP HECEIRRHIR PEERIFTSSE
EICPRVEGEG TQSCLWASAV NVRDKYIYVT QPKQNRVMII DIQTQKAMQY LDVDPVPTKL
HYDKSHDQVW VLSWGDMHKS SPTLQVIPEA SAGQEQHVIR APFQGVEDFF IPPTNLIINH
VRFGFIFNKS KSAVHKIDLE TVTHIKTINF KNYSCVPQTM AYTHLGGYFF VQCRRSSSVA
VTPQLIIDSV TDAVVGPNGD VSGTPHVSPD GRYLVSADEA TGRIKVQALT VRGEIQLIYD
LQTSIHVSDL TFQPSFTEGN QYYIYATSHL QTDVLFVELS TGKMNVLKNL KDPITSKDWP
WSNYNRIMKD SGLFGQYLIT PAKESLFVIN GRQNTLRCEV SGIRRGNTIV WVGEV
//
