ID A0A093CP90_TAUER Unreviewed; 1354 AA.
AC A0A093CP90;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Regulator of G-protein signaling 12 {ECO:0000313|EMBL:KFV17690.1};
DE Flags: Fragment;
GN ORFNames=N340_02193 {ECO:0000313|EMBL:KFV17690.1};
OS Tauraco erythrolophus (Red-crested turaco).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Musophagiformes; Musophagidae; Tauraco.
OX NCBI_TaxID=121530 {ECO:0000313|EMBL:KFV17690.1, ECO:0000313|Proteomes:UP000053661};
RN [1] {ECO:0000313|EMBL:KFV17690.1, ECO:0000313|Proteomes:UP000053661}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N340 {ECO:0000313|EMBL:KFV17690.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KL467793; KFV17690.1; -; Genomic_DNA.
DR Proteomes; UP000053661; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd13162; PTB_RGS12; 1.
DR CDD; cd17136; RBD1_RGS12; 1.
DR CDD; cd17138; RBD2_RGS12; 1.
DR CDD; cd08742; RGS_RGS12; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR037880; RGS12_RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945:SF1; REGULATOR OF G-PROTEIN SIGNALING 12; 1.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF02188; GoLoco; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF16613; RGS12_us1; 1.
DR Pfam; PF16611; RGS12_us2; 1.
DR Pfam; PF16612; RGS12_usC; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50898; RBD; 2.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000053661};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 22..99
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 226..338
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 708..825
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 957..1027
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 1029..1099
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 606..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..867
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..890
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1244..1260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1354
FT /evidence="ECO:0000313|EMBL:KFV17690.1"
SQ SEQUENCE 1354 AA; 149484 MW; EB6E69B741A05ACF CRC64;
MYRPGETVKR RLNMHAPPRI RSVEVARGRA GYGFTLSGQA PCVLSCVMKG SPADYVGLKA
GDQIFAVNEI NVKKASHEDV VKLIGKCSGV LHMVIAEGIS HIDSCSSDEE VGFYDGKGWL
KPKPDSKALG INRAEKVVEE MQSGGIFNMI FENPTLCAGN SDNSAPKQRS FSDSAAIKFE
TGNESVSNPN LLSKEEMSKV LNDDSVFRIG LEGAEDFGLD ASILNVAMIV GYLGSIELPS
TTSNLENESL QAIRGCMRRL RAEQKIHSLV MMKIMHDCIQ LCSDKSGVVA EYPAEKLAFS
AVCPDDRRFF GLVTMQTNDD ASLAQEDEGV LRTSCHVFMV DPELFHHKIH QGIARRFGLE
CTADPDTNGC LEFPTSSLPV LQFISVLYRD MGELIEGMRA RAFLDGDVDA HQNNSTSSNS
DSGIGNFNQE EKNNRVLVVD LGSNPSKHIP NSMWENPVGR GQNQPASHWN GFCHEQEGNI
PLEVIQNEKS QNVSKHLSPS ARIEVPLVSS RNSVPPSKKN AAGIGNQRWL PVHVLQEWQH
GNASDQESYT DSTDGWSSVN CGTLPPPMNK IPADRYRVDG NFGQPQLKSH KNEWSKKMFC
MQNKFGPPHS IRKSKEDKKG AKFGHPVGLN QAPPPRSSVR RSFGRSKRFS ITRSLDDLES
ATVSDGELNS TDLKDCISEN SLSSNASLPS VQSCRRLRER RVASWAVSFE RLLQDPVGVK
YFSEFLRKEF SEENILFWQA CEYFNHVPAH DKKELSYRAR EIFSKFLCSK ATTPVNIDSQ
AQLADDILNS PHPDMFKEQQ LQIFNLMKFD SYTRFLKSPL YQECILAEVE GRPLPDPQHV
PSSPTSKHSI SSEKSNISTP KKLSGKSKSG RSLNEESGEE DTEKKKRGTF FSWSRSKSLG
KSQKRKENGD YPNDSIQSNG LSYRRESQGS MSSTASLDLS EASRLPAFVP DKDKSPKYCC
INLPDGSSSK MAIKSGFSIK EVLSGLCEKH GINIAAVDLF LVGGDKPLVL HQDSSILESR
DLRLEKRTLF RLDLVPINRS VGLKAKPTKP VTEVLRPVVA KYGLNLNELV ARLNGEQEPL
DLGVPISNLD GQRVVLDEKE PTKGRVFTDK QKGASVKQSA TVTTSRNQVS TGEGRTLGKS
NSIKMKGENG KNAREVRLSK REDSIAKIGK KKCQKINLDE AEEFFELISK AQSNRADDQR
GLLRKEDLVL PDFLRLPPTG PEPSSSTPTG PKGLSKRVSK NDGKDGCTSP SGKQESVQNF
SENSVKKMGY SENKHKSALT ALHSQKTISV PFNTALSPIL HAQENNATIW KRQSRELQAE
GIQMVDDDNV ADLTLVAEGD ISSPNSTLLP PPPP
//
