ID   A0A093CVU2_9AVES        Unreviewed;      1175 AA.
AC   A0A093CVU2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE            EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE   AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030520};
DE   Flags: Fragment;
GN   ORFNames=N339_01309 {ECO:0000313|EMBL:KFV16402.1};
OS   Pterocles gutturalis (yellow-throated sandgrouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Ciconiiformes; Pteroclidae; Pterocles.
OX   NCBI_TaxID=240206 {ECO:0000313|EMBL:KFV16402.1, ECO:0000313|Proteomes:UP000053149};
RN   [1] {ECO:0000313|EMBL:KFV16402.1, ECO:0000313|Proteomes:UP000053149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N339 {ECO:0000313|EMBL:KFV16402.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR   EMBL; KL248492; KFV16402.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093CVU2; -.
DR   Proteomes; UP000053149; Unassembled WGS sequence.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd07959; Anticodon_Ia_Leu_AEc; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR004493; Leu-tRNA-synth_Ia_arc/euk.
DR   InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR   NCBIfam; TIGR00395; leuS_arch; 1.
DR   PANTHER; PTHR45794:SF1; LEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR   PANTHER; PTHR45794; LEUCYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF08264; Anticodon_1; 1.
DR   Pfam; PF00133; tRNA-synt_1; 2.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363035};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363035};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053149}.
FT   DOMAIN          18..101
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          187..754
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          793..912
FT                   /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT                   anticodon-binding"
FT                   /evidence="ECO:0000259|Pfam:PF08264"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFV16402.1"
FT   NON_TER         1175
FT                   /evidence="ECO:0000313|EMBL:KFV16402.1"
SQ   SEQUENCE   1175 AA;  134305 MW;  E34B9D994D7C2BC1 CRC64;
     ERKGTAKVDF LKRIEKEIQQ KWDDERVFEI NASDRQNQKS KGKYFVTFPY PYMNGRLHLG
     HTFSLSKCEF AVGYQRLKGK NCLFPFGLHC TGMPIKACAD KLKREMELYG CPPEFPDEEE
     EEEENAAKKE EEIVIKDKAK GKKSKAAAKT GSSKYQWGIM KSLGLSDAEV VSFSEAEHWL
     DYFPPLAVQD LKSMGLKVDW RRSFVTTDVN PYYDSFVRWQ FLTLKERNKI KFGKRYTIYS
     PKDGQPCMDH DRQTGEGVGP QEYTLIKMKV LDPYPTKLSG LRGKNIFLVA ATLRPETMFG
     QTNCWVRPDM KYIGFETANG DIFICTQRAA RNMSYQGFTK DNGVVPVVKE LMGEEILGAA
     LSAPLTVYKV IYALPMLTIK EDKGTGVVTS VPSDAPDDIA ALRDLKKKPA LRVKYGIKDE
     MVLPFEPVPI IEIPGYGNLC APSVCDELKI QSQNDREKLA EAKERVYLKG FYEGVMLVDG
     FKGQKVQDVK KIIQKMMVDN DEAMIYMEPE KQVISRSADE CVVALCDQWY LDYGEVNWKK
     QASECLKHLE TFCEETRRNF EATLGWLQEH ACSRTYGLGT RLPWDEQWLI ESLSDSTIYM
     AYYTVAHLLQ GGNLRGQGES PLGIRAHQMS KEVWDYIFFK AAPFPKTAIP KEKLDKLKEE
     FEFWYPVDLR VSGKDLVPNH LSYYLYNHVA MWSDQREKWP VAVRANGHLL LNSEKMSKST
     GNFLTLTQAV EKFSADGMRL ALADAGDTVE DANFVETMAD AGILRLYTWV EWVKEMIANR
     DSLRSGPADT FNDRVFASEM SAGIMKTDQN YEKMMFKEAL KTGFFEFQAA KDKYRELAIE
     GMHRELVFQF IEVQTLLLAP ICPHLCEHVW SLLGKPDSIM RASWPTAGPV DEVLIRSSQY
     LMEAAHDLRL RLKSYMAPVK GKKSTKEPSQ KPSHCTIYVA KNYPSWQHTT LSVLRKHYQA
     SGGQLPDNKV IASELNALPE LKKYMKKVMP FVAMIKENLE KNGSRVLDLE LEFDERAVLM
     ENIVYLTNSL ELDHIEVKFA SEAEDKIKED CCPGKPFSIF RTEPSVSIFL VNPQPSNGHF
     STKIEIRQGD NRETVIRRLM KMDRGIKDLS KVKLMRFDDP VLGPRRVPVL GKEEAEKTPI
     LEQAIFHIDL DEKHVRVTEN GLTKDIGDTI VYLVH
//