ID A0A093CVU2_9AVES Unreviewed; 1175 AA.
AC A0A093CVU2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030520};
DE Flags: Fragment;
GN ORFNames=N339_01309 {ECO:0000313|EMBL:KFV16402.1};
OS Pterocles gutturalis (yellow-throated sandgrouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Ciconiiformes; Pteroclidae; Pterocles.
OX NCBI_TaxID=240206 {ECO:0000313|EMBL:KFV16402.1, ECO:0000313|Proteomes:UP000053149};
RN [1] {ECO:0000313|EMBL:KFV16402.1, ECO:0000313|Proteomes:UP000053149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N339 {ECO:0000313|EMBL:KFV16402.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR EMBL; KL248492; KFV16402.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093CVU2; -.
DR Proteomes; UP000053149; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07959; Anticodon_Ia_Leu_AEc; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR004493; Leu-tRNA-synth_Ia_arc/euk.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00395; leuS_arch; 1.
DR PANTHER; PTHR45794:SF1; LEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR45794; LEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 2.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000053149}.
FT DOMAIN 18..101
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 187..754
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 793..912
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV16402.1"
FT NON_TER 1175
FT /evidence="ECO:0000313|EMBL:KFV16402.1"
SQ SEQUENCE 1175 AA; 134305 MW; E34B9D994D7C2BC1 CRC64;
ERKGTAKVDF LKRIEKEIQQ KWDDERVFEI NASDRQNQKS KGKYFVTFPY PYMNGRLHLG
HTFSLSKCEF AVGYQRLKGK NCLFPFGLHC TGMPIKACAD KLKREMELYG CPPEFPDEEE
EEEENAAKKE EEIVIKDKAK GKKSKAAAKT GSSKYQWGIM KSLGLSDAEV VSFSEAEHWL
DYFPPLAVQD LKSMGLKVDW RRSFVTTDVN PYYDSFVRWQ FLTLKERNKI KFGKRYTIYS
PKDGQPCMDH DRQTGEGVGP QEYTLIKMKV LDPYPTKLSG LRGKNIFLVA ATLRPETMFG
QTNCWVRPDM KYIGFETANG DIFICTQRAA RNMSYQGFTK DNGVVPVVKE LMGEEILGAA
LSAPLTVYKV IYALPMLTIK EDKGTGVVTS VPSDAPDDIA ALRDLKKKPA LRVKYGIKDE
MVLPFEPVPI IEIPGYGNLC APSVCDELKI QSQNDREKLA EAKERVYLKG FYEGVMLVDG
FKGQKVQDVK KIIQKMMVDN DEAMIYMEPE KQVISRSADE CVVALCDQWY LDYGEVNWKK
QASECLKHLE TFCEETRRNF EATLGWLQEH ACSRTYGLGT RLPWDEQWLI ESLSDSTIYM
AYYTVAHLLQ GGNLRGQGES PLGIRAHQMS KEVWDYIFFK AAPFPKTAIP KEKLDKLKEE
FEFWYPVDLR VSGKDLVPNH LSYYLYNHVA MWSDQREKWP VAVRANGHLL LNSEKMSKST
GNFLTLTQAV EKFSADGMRL ALADAGDTVE DANFVETMAD AGILRLYTWV EWVKEMIANR
DSLRSGPADT FNDRVFASEM SAGIMKTDQN YEKMMFKEAL KTGFFEFQAA KDKYRELAIE
GMHRELVFQF IEVQTLLLAP ICPHLCEHVW SLLGKPDSIM RASWPTAGPV DEVLIRSSQY
LMEAAHDLRL RLKSYMAPVK GKKSTKEPSQ KPSHCTIYVA KNYPSWQHTT LSVLRKHYQA
SGGQLPDNKV IASELNALPE LKKYMKKVMP FVAMIKENLE KNGSRVLDLE LEFDERAVLM
ENIVYLTNSL ELDHIEVKFA SEAEDKIKED CCPGKPFSIF RTEPSVSIFL VNPQPSNGHF
STKIEIRQGD NRETVIRRLM KMDRGIKDLS KVKLMRFDDP VLGPRRVPVL GKEEAEKTPI
LEQAIFHIDL DEKHVRVTEN GLTKDIGDTI VYLVH
//