ID A0A093D1K7_TAUER Unreviewed; 879 AA.
AC A0A093D1K7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=[heparan sulfate]-glucosamine N-sulfotransferase {ECO:0000256|ARBA:ARBA00012979};
DE EC=2.8.2.8 {ECO:0000256|ARBA:ARBA00012979};
GN ORFNames=N340_09193 {ECO:0000313|EMBL:KFV20633.1};
OS Tauraco erythrolophus (Red-crested turaco).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Musophagiformes; Musophagidae; Tauraco.
OX NCBI_TaxID=121530 {ECO:0000313|EMBL:KFV20633.1, ECO:0000313|Proteomes:UP000053661};
RN [1] {ECO:0000313|EMBL:KFV20633.1, ECO:0000313|Proteomes:UP000053661}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N340 {ECO:0000313|EMBL:KFV20633.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005093}.
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family. NDST subfamily.
CC {ECO:0000256|ARBA:ARBA00010420}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL476013; KFV20633.1; -; Genomic_DNA.
DR RefSeq; XP_009989121.1; XM_009990819.1.
DR AlphaFoldDB; A0A093D1K7; -.
DR GeneID; 104382789; -.
DR KEGG; teo:104382789; -.
DR CTD; 8509; -.
DR OrthoDB; 2913264at2759; -.
DR UniPathway; UPA00756; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000053661; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0019213; F:deacetylase activity; IEA:UniProt.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR021930; Heparan_SO4_deacetylase.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF53; BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE 2; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF12062; HSNSD; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053661};
KW Transferase {ECO:0000313|EMBL:KFV20633.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..510
FT /note="Heparan sulphate-N-deacetylase"
FT /evidence="ECO:0000259|Pfam:PF12062"
FT DOMAIN 600..849
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 609
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 707
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 812
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 828..832
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 813..823
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 879 AA; 101396 MW; 82A906F691B0A2F8 CRC64;
MIQLWKVVRH VRQLELHRLI LLLIAFSLIS MCILAYYVTN SPKIKEPPPL PFSDCSNQHR
ILIPPQASWR LTKSVDTSRT DPVVLVFVES IYSQLGQEIV AILESSRFKY RTEIAPGKGD
MPTLTDKDRG RYALIIYENI LKYVNLDAWN RELLDKYCVE YGVGIIGFFK ANENSLLSAQ
LKGFPLFLHS NLGLRDYHIN PSAPLLYVTR ANEVEQGPLP GDDWTVFQSN HSTYEPVLLA
STKSSESIPH LATHKALHAT VVQDLGLHDG IQRVLFGNNL NFWLHKLIFV DAIAYLTGKR
LCLTLDRYIL VDIDDIFVGK EGTRMKVSDV EALLSTQNKL RTLVPNFTFN LGFSGKFYHT
GTDEEDEGDD MLLKHRKEFW WFPHMWSHMQ PHLFHNVTVL AEQMKLNKQF AVEHGIPTDL
GYAVAPHHSG VYPVHTQLYE AWKSVWSIQV TSTEEYPHLR PARYRRGFIH NGIMVLPRQT
CGLFTHTIFY NEYPGGSKEL DKSIRGGELF LTVLLNPISI FMTHLSNYGN DRLGLYTFES
LVKFVQCWTN LRLQTLPPVQ LAKKYFEIFP QEKNPLWQNP CDDKRHKDIW SKEKTCDRLP
KFLIVGPQKT GTTAVHFFLT MHPAVTSNFP SPSTFEEIQF FNGPNYHKGI DWYMEFFPIP
SNASTDFMFE KSANYFDTEV VPKRGAALLP RAKIITVLIN PADRAYSWYQ HQRAHNDPVA
LNYTFYQVIS AKSQAPQELR NLQSRCLLPG WYSAHLERWL TYYPSGQLLI VDGQELRHNP
AAVMDNIQKF LGVTPLFNYT QALRFDEVKG FWCQLLDGGK TKCLGKSKGR KYPDMDSSSR
LFLRGFYREH NIELSKLMNR LGQPLPTWLR EELQNSSWS
//