ID A0A093E2W5_9AVES Unreviewed; 866 AA.
AC A0A093E2W5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 13-SEP-2023, entry version 25.
DE SubName: Full=Protein patched 1 {ECO:0000313|EMBL:KFV08801.1};
DE Flags: Fragment;
GN ORFNames=N339_10600 {ECO:0000313|EMBL:KFV08801.1};
OS Pterocles gutturalis (yellow-throated sandgrouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Ciconiiformes; Pteroclidae; Pterocles.
OX NCBI_TaxID=240206 {ECO:0000313|EMBL:KFV08801.1, ECO:0000313|Proteomes:UP000053149};
RN [1] {ECO:0000313|EMBL:KFV08801.1, ECO:0000313|Proteomes:UP000053149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N339 {ECO:0000313|EMBL:KFV08801.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; KL235942; KFV08801.1; -; Genomic_DNA.
DR RefSeq; XP_010074047.1; XM_010075745.1.
DR AlphaFoldDB; A0A093E2W5; -.
DR GeneID; 104463424; -.
DR KEGG; pguu:104463424; -.
DR CTD; 5727; -.
DR OrthoDB; 1219406at2759; -.
DR Proteomes; UP000053149; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000053149};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..22
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 611..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..630
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..746
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV08801.1"
FT NON_TER 866
FT /evidence="ECO:0000313|EMBL:KFV08801.1"
SQ SEQUENCE 866 AA; 97015 MW; F2526073261D445F CRC64;
AAVVVVFNFA MVLLIFPAIL SMDLYRREDR RLDIFCCFTS PCVTRVIQIE PQVYAENDNT
CYSPPPPYSS HSFAHETQIT MQSTVQLRTE YDPHTQVYYT TAEPRSEISV QPVTVTQDNL
SCQSPESTSS TRDLLSQFSD SSMHCLEPPC TKWTLSSFAE KHYAPFLLKP KAKIVVIFLF
LGLLGLSLYG TTRVRDGLDL TDIVPRETRE YDFIAAQFKY FSFYNMYIVT QKADYPNVQH
LLYELHRSFS NVTYVLLEED RQLPKMWLHY FRDWLQGLQD AFDSDWESGK ITYNNYKNGS
DDAVLAYKLL VQTGNRAKPI DISQLTKQRL VDADGIINPN AFYIYLTAWV SNDPVAYAAS
QANIRPHRPE WVHDKADYMP ETRLRIPAAE PIEYAQFPFY LNGLRETSDF VEAIEKVRAI
CSNYTSLGIA SYPNGYPFLF WEQYIGLRHW LLLSISVVLA CTFLVCALFL LNPWTAGIIV
VVLALMTVEL FGMMGLIGIK LSAVPVVILI ASVGIGVEFT VHVALAFLTA IGDRNHRAVL
ALEHMFAPVL DGAVSTLLGV LMLAGSEFDF IVRYFFAVLA ILTILGVLNG LVLLPVLLSF
FGPYPEISPA NGRNRLPTPS PEPPPSIVRF ALPPGHVNNG SDSSDSEYSS QTTVSGISEE
LHQYEATQGP GAPVHQIIVE ATENPVFARS TVVQPETRHQ SSPRLQLNPE SSTQQAWRQG
RQPKREAREG LRPPPYRPRR DAFEISTEGH SGPSNRDRVG HRARSHNMRS PVFSAVGAAG
PAYCQPITTV TASASVTVAV HPAVHSHSSR GGSFPSYEGY HETDHGPFED PHVPFNVRCE
RRNSKIEVIE LQDVECEERI PGNSSQ
//
