ID A0A093EM04_TYTAL Unreviewed; 298 AA.
AC A0A093EM04;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Transforming growth factor beta-2 proprotein {ECO:0000256|ARBA:ARBA00018531};
DE Flags: Fragment;
GN ORFNames=N341_06943 {ECO:0000313|EMBL:KFV46271.1};
OS Tyto alba (Barn owl).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Strigiformes; Tytonidae; Tyto.
OX NCBI_TaxID=56313 {ECO:0000313|EMBL:KFV46271.1, ECO:0000313|Proteomes:UP000054190};
RN [1] {ECO:0000313|EMBL:KFV46271.1, ECO:0000313|Proteomes:UP000054190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N341 {ECO:0000313|EMBL:KFV46271.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Precursor of the Latency-associated peptide (LAP) and
CC Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute
CC the regulatory and active subunit of TGF-beta-2, respectively.
CC {ECO:0000256|ARBA:ARBA00034081}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KK376605; KFV46271.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093EM04; -.
DR Proteomes; UP000054190; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0009888; P:tissue development; IEA:UniProt.
DR CDD; cd19385; TGF_beta_TGFB2; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR016319; TGF-beta.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR003940; TGFb2.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR PANTHER; PTHR11848:SF141; TRANSFORMING GROWTH FACTOR BETA-2 PROPROTEIN; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PIRSF; PIRSF001787; TGF-beta; 1.
DR PRINTS; PR01425; TGFBETA2.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001787-1};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW Reference proteome {ECO:0000313|Proteomes:UP000054190};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 183..298
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT DISULFID 193..202
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 201..264
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 230..295
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 234..297
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 263
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV46271.1"
FT NON_TER 298
FT /evidence="ECO:0000313|EMBL:KFV46271.1"
SQ SEQUENCE 298 AA; 34405 MW; DB1260B479C6658D CRC64;
DAIPPSYYSL YFRIVRFDVS AMEKNASNLV KAEFRVFRLQ NSKARVSEQR IELYQVLKSK
ELSSPGQRYI DSKVVKTRAE GEWLSFDVTE AVHEWLHHRD RNLGFKISLH CPCCTFVPSN
NYIIPNKSEE LEARFAGIDD YTYSSGDVKA LKSNRKKYSG KTPHLLLMLL PSYRLESQQP
SRRKKRALDA AYCFRNVQDN CCLRPLYIDF KRDLGWKWIH EPKGYHANFC AGACPYLWSS
DTQHSRVLSL YNTINPEASA SPCCVSQDLE PLTILYYIGK TPKIEQLSNM IVKSCKCS
//
