ID A0A093F0Y4_GAVST Unreviewed; 1773 AA.
AC A0A093F0Y4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE Flags: Fragment;
GN ORFNames=N328_04773 {ECO:0000313|EMBL:KFV50135.1};
OS Gavia stellata (Red-throated diver) (Colymbus stellatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gaviiformes; Gaviidae; Gavia.
OX NCBI_TaxID=37040 {ECO:0000313|EMBL:KFV50135.1, ECO:0000313|Proteomes:UP000054313};
RN [1] {ECO:0000313|EMBL:KFV50135.1, ECO:0000313|Proteomes:UP000054313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N328 {ECO:0000313|EMBL:KFV50135.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Multimeric. Interacts with F8.
CC {ECO:0000256|ARBA:ARBA00025858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; KK618964; KFV50135.1; -; Genomic_DNA.
DR Proteomes; UP000054313; Unassembled WGS sequence.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 4.
DR CDD; cd01450; vWFA_subfamily_ECM; 3.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 3.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR032361; VWA_N2.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF361; VON WILLEBRAND FACTOR; 1.
DR Pfam; PF08742; C8; 2.
DR Pfam; PF01826; TIL; 3.
DR Pfam; PF00092; VWA; 3.
DR Pfam; PF16164; VWA_N2; 1.
DR Pfam; PF00094; VWD; 2.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00832; C8; 2.
DR SMART; SM00327; VWA; 3.
DR SMART; SM00214; VWC; 3.
DR SMART; SM00215; VWC_out; 1.
DR SMART; SM00216; VWD; 2.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 4.
DR SUPFAM; SSF53300; vWA-like; 3.
DR PROSITE; PS50234; VWFA; 3.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
DR PROSITE; PS51233; VWFD; 2.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000054313};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 217..384
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 620..796
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 842..1022
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1031..1212
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1289..1465
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1598..1671
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV50135.1"
FT NON_TER 1773
FT /evidence="ECO:0000313|EMBL:KFV50135.1"
SQ SEQUENCE 1773 AA; 197706 MW; 9A48E1478243B586 CRC64;
AMTCPEGQVY RQCGTPCNQT CRSLSYPDED CDELCVEGCY CPPGHYLDER EECVPKSHCS
CYYDGEIFQP EDIFSDHYTM CYCENGFMHC STNRVPGAFL PDVFADERPS ARIKRSLACR
YPMERFVCPA NNPRAEGLEC AKTCQNYDLE CISHGCISGC LCPRGMVRHE NKCVAPERCP
CFHNGREYAK GETVINDCNT CVCRGRKWEC TKNTCDGTCT VIGTAHYLTF DGLKYKFPGN
CQYVLVQDFC KDDSGTFRIL ISNEGCGFTG EKCTKRVIIL YESGEIELFN GNVNIKVPPK
DDNDLEVMKS GRYYIILLGK NISVTWDLAM GVSVILKGNF KDQVCGLCGN FDGIQNNDLT
SSNEHLEVDP VDFGNSWKVN PYCADVEKEQ TLMSPLCNGN VVKQVMVETS CSILSGDLFE
ECKKLVNPEP YIDICMYDTC ACESIGDCAC FCDAIAAYAH VCAQKGVAVH WRSPALCPQS
CEDLNKQELD YQCEWRYNSC GPACPVTCQH PQPLECPLQC VEGCHVHCPA GKILDELSLD
CVSPEDCPMC AVGDVKVSHG RRIVLNRDDP QHCQSCVCEG KNLTCVVCEP VEETLTPTTP
APEEDIELPP SEYSCSKMMD LAFLMDGSNK LSEEDFQQLK TFITGMMKKL HISQKKIRVS
ILVYRAGPTI YLGLKDIKTQ SQMRKIVQNI KYTGDEVASA AEVLKYTVFH VFGKAERTNA
ARIAVLFIAS KSPGKLRSIL TALKNKKITV IPVGIGPYVS VEQIRFIEKQ SPDNRAFLMN
NVLELMDNRD LLIDHLCDLG PEESSVLQAT STPTISSVLF PPWSLTPPPP HFSEKPTHKR
LDIAFIVEGS DNVGEENFNI VKKFLERVVT EMNIGQEDIH VTVMQYAETV TLEYSFREIQ
SKESIIEKVR SIPYQGGKAT NTGNALDYIS KHTFTSVNGG RQDVPHLVYM VSSSPSTDVI
TRPPGSINVI PIGITPNANI QELRKISQPN NPIILHSYST LIEEALELVL QSCCSRKLWT
EIPELCNKPM DVMFLLDGSS SIGALEFEEM KNFVRAFIES AEISNSSIHV SVLQYARENN
LEISWNMPQE TENLVEMVRS IQQREQGPTR LGKAIDFVVQ NAMSESHGGR PSASKVAIVI
VSGRSEDAVE AAALSARMNR VSLFPIGVGN TYDEEQLRTL TGPSAANRIM KLQNFEDLST
MITLNSEFIK KLCMDPVREC IDEDGNKKKP GDKWTLPDQC HTVTCFPGDY TVLESHQINC
ERMPKPVCHS NLPAVKIEET CGCRWMCPCV CIGSSSRHIV TFDGLNFKLT GNCSYTLFQD
MQNDVEVLLH EGPCRATPKM NCMDSIEVKH RGVSVQLFSD MAVAVNGERV HIPYSSSLFE
VTVYGAIMHE IKFSHLGHNL TFTPRNNEFI LKLNSKSFSS GTKGLCGVCD QNHINDFTLH
DGSVTPESSV FIQDWTVEEP GKICEIRRED GCSEHATSHC RLLLSDRFAE CHRVISPNMF
YEACTESSCY EDEACEMITS YTHICRENGV CIDWRTPEFC PMKCPAYLTY DHCHRACIKH
CENSTKLSVC KDYPTEGCFC PHGQVIFNDS CVDEEICTQC ISEDGTRHQH METWIPTNEP
CKICTCLDNK KVNCTVRPCP TAKPVQCGPC EVPRLRRDPG QCCPTYECVC DLVSCDLPPA
PVCGFGLQLA LTNPGECRPN YTCECNREAC SLVQIPSCPP HRELTVKKTE CCDEYECTCS
CTNSTVSCPL GYLSRSVSND CGCVSTTCVP GRV
//
